Huilan Yue

ORCID: 0000-0003-4457-3233
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About
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Research Areas
  • Sulfur-Based Synthesis Techniques
  • Catalytic C–H Functionalization Methods
  • Radical Photochemical Reactions
  • Chemical Synthesis and Reactions
  • Natural Antidiabetic Agents Studies
  • Natural product bioactivities and synthesis
  • Synthesis and Catalytic Reactions
  • Chromatography in Natural Products
  • Phytochemicals and Antioxidant Activities
  • Cyclopropane Reaction Mechanisms
  • Synthesis and Biological Evaluation
  • Phytochemistry and Biological Activities
  • Catalytic Cross-Coupling Reactions
  • Click Chemistry and Applications
  • Pharmacological Effects of Natural Compounds
  • Alkaloids: synthesis and pharmacology
  • Medicinal Plants and Bioactive Compounds
  • Oxidative Organic Chemistry Reactions
  • Fluorine in Organic Chemistry
  • Natural Compound Pharmacology Studies
  • Chemical synthesis and alkaloids
  • Synthesis of heterocyclic compounds
  • Diet, Metabolism, and Disease
  • Plant-derived Lignans Synthesis and Bioactivity
  • Catalytic Alkyne Reactions

Northwest Institute of Plateau Biology
2017-2025

Qinghai Tibetan Hospital
2018-2025

Chinese Academy of Sciences
2015-2025

Institute of Tibetan Plateau Research
2013-2021

Qufu Normal University
2020

Xinjiang Institute of Ecology and Geography
2012-2019

Max-Planck-Institut für Kohlenforschung
2019

Beijing Research Center for Agricultural and Standards and Testing
2019

Beijing Municipal Ecological and Environmental Monitoring Center
2019

Chung Shan Medical University
2019

A novel and efficient visible-light-induced C(sp2)–H/N–H cross-dehydrogenative coupling (CDC)-amination with both primary secondary aliphatic amines at room temperature in air is developed. This photocatalytic reaction allows the direct formation of 3-aminoquinoxalin-2(1H)-ones via CDC-amination absence any external oxidant added from outside. Preliminary mechanistic studies reveal that present proceeds through a radical process.

10.1021/acs.orglett.8b03079 article EN Organic Letters 2018-10-29

A facile visible-light-driven method has been developed to construct sulfoxides from aryldiazo sulfones and thiols in air under photocatalyst-free conditions.

10.1039/c9gc00222g article EN Green Chemistry 2019-01-01

A convenient and practical metal-free visible-light-promoted method to synthesize 3-oxyalkylated quinoxalin-2(1H)-ones was developed at room temperature. The present transformation could be accomplished through Rose Bengal-catalyzed C–H/C–H cross-dehydrogenative-coupling of quinoxalin-2(H)-ones with simple ethers, providing an efficient operationally access various moderate good yields.

10.1021/acssuschemeng.8b04652 article EN ACS Sustainable Chemistry & Engineering 2018-11-07

A visible-light-induced strategy has been established for the synthesis of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones at room temperature in air.

10.1039/c7gc02330h article EN Green Chemistry 2017-01-01

Visible-light-mediated procedure has been developed for the synthesis of 3-acyl quinoxalin-2(1<italic>H</italic>)-ones through acridine red catalyzed decarboxylative acylation α-oxo-carboxylic acids with quinoxalin-2(1<italic>H</italic>)-ones.

10.1039/c9qo01334b article EN Organic Chemistry Frontiers 2020-01-01

A convenient visible-light-induced method for the synthesis of thiocarbamates from isocyanides, thiols, and water has been developed under mild reaction conditions. The present protocol offers a cost-effective operationally straightforward approach to various in moderate good yields by simple use cheap Rose Bengal as photocatalyst reagent well an environmentally benign cosolvent.

10.1021/acs.orglett.8b02231 article EN Organic Letters 2018-08-21

Visible-light-induced oxyazidation of alkenes for the construction α-azidoketones has been developed at room temperature in air.

10.1039/c8gc01245h article EN Green Chemistry 2018-01-01

A K2S2O8-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1H)-ones under metal-free conditions. The present reaction could be accomplished through trifluoroalkylation with unactivated alkenes and Langlois' reagent (CF3SO2Na), which provided a highly attractive approach to access series biologically important quinoxalin-2(1H)-ones.

10.1021/acs.joc.9b03505 article EN The Journal of Organic Chemistry 2020-05-11

A novel visible-light-induced and Rose Bengal catalyzed strategy has been developed for the synthesis of α-ketoamides <italic>via</italic> decarboxylative acylations isocyanides with α-oxocarboxylic acids water under mild conditions.

10.1039/c9gc03253c article EN Green Chemistry 2019-01-01

A convenient and eco-friendly visible-light promoted multicomponent protocol has been developed for the synthesis of S -alkyl phosphorothioates by using elemental sulfur as cheap odorless source.

10.1039/d2gc00903j article EN Green Chemistry 2022-01-01

A facile I2O5-mediated direct oxidative coupling of aromatic alkenes with thiols toward vinyl sulfones has been developed under metal-free conditions. This methodology provides a convenient and efficient approach to various (E)-vinyl from readily available starting materials excellent regioselectivity. The present reaction, not only expands the scope functionalization thiols, but also makes it practical powerful complement traditional methods for synthesis sulfones.

10.1021/acs.joc.7b00994 article EN The Journal of Organic Chemistry 2017-06-09

Diabetes mellitus (DM) is a serious metabolic disorder, where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical erythritol C4 polyol approved by the U.S. Food and Drug Administration for use as sweetener. Here, we examined potential role in control of levels DM. An anti-postprandial hyperglycemia effect upon administration (500 mg kg-1) was demonstrated alloxan-induced DM model mice monitoring changes after intragastric drugs...

10.1021/acs.jafc.7b05033 article EN Journal of Agricultural and Food Chemistry 2018-01-24

Abstract A catalyst‐free strategy has been established for the synthesis of β‐oxo sulfones via visible light‐induced oxysulfonylation alkenes with arylazo dioxygen in air. The present photoinduced transformation proceeds smoothly at room temperature absence an external photosensitizer, which not only provides a mild and efficient approach to various sulfones, but also opens different reaction mode photochemical sulfones. magnified image

10.1002/adsc.201900984 article EN Advanced Synthesis & Catalysis 2019-09-27

The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to treat diabetes and prevent diabetes-related complications. Resveratroloside a monoglucosylated form stilbene that present in red wine, grapes, several traditional medicinal plants. In our study, the effect resveratroloside on reducing PBG was studied vitro vivo. comparison starch treatment alone, oral administration resveratroloside-starch complexes significantly inhibited increase dose-dependent...

10.1021/acs.jafc.9b00455 article EN Journal of Agricultural and Food Chemistry 2019-02-20

A novel molecular iodine-catalyzed protocol for the construction of thiocarbamates from readily available sodium sulfinates, isocyanides, and water has been described. The present methodology offers a facile practical route to variety in moderate good yields with favorable functional group tolerance by use odorless sulfinates as sulfur source. mechanistic studies suggest transformation involves radical process.

10.1021/acs.joc.8b02844 article EN The Journal of Organic Chemistry 2019-02-18

α-glucosidase is a major enzyme that involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by its mechanism were firstly investigated using kinetics analysis, real-time interaction analysis between surface plasmon resonance (SPR), molecular docking simulation. The results showed was high potential reversible competitive inhibitor, with maximum half inhibitory concentration (IC50) 4.66 ± 0.27 mg/L. binding affinities assessed an SPR detection...

10.3390/molecules26154566 article EN cc-by Molecules 2021-07-28

A visible-light photoredox-catalyzed four component reaction of quinoxalin-2(1 H )-ones, alkenes, aryldiazonium, and sodium metabisulfite leading to sulfone-containing )-ones has been developed.

10.1039/d1qo00816a article EN Organic Chemistry Frontiers 2021-01-01

Abstract A novel and efficient trifluoromethanesulfonic acid‐catalyzed sp 3 ‐ 2 CC bond formation reaction through the direct coupling of alcohols with alkenes has been realized under mild conditions. The present protocol provides an attractive approach to a diverse range polysubstituted olefins in good excellent yields high stereo‐ regioselectivities.

10.1002/adsc.201100262 article EN Advanced Synthesis & Catalysis 2011-11-01

A new copper-catalyzed selective synthesis of N1- and N2-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction alkynes, TMSN3, ethers. Through this methodology, series could be efficiently regioselectively obtained from simple readily available starting materials with favorable functional group tolerance.

10.1021/acs.orglett.9b02295 article EN Organic Letters 2019-09-04
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