A5014962959- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Multicomponent Synthesis of Heterocycles
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- VLSI and FPGA Design Techniques
- Synthesis and Characterization of Pyrroles
- Porphyrin and Phthalocyanine Chemistry
- Low-power high-performance VLSI design
- VLSI and Analog Circuit Testing
- Organic Light-Emitting Diodes Research
- Click Chemistry and Applications
- Catalytic Alkyne Reactions
- Surfactants and Colloidal Systems
- Epigenetics and DNA Methylation
- Catalytic C–H Functionalization Methods
- Influenza Virus Research Studies
- Acute Myeloid Leukemia Research
- Polydiacetylene-based materials and applications
- Synthesis of heterocyclic compounds
- Ureteral procedures and complications
Southern Medical University
2016-2025
South China University of Technology
2007-2025
Ganzhou People's Hospital
2024
Nanchang University
2024
Xiamen University of Technology
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2020-2023
Nanfang Hospital
2014-2016
Shanghai University
2014-2015
CreoNex Systems (United States)
2004-2010
Matrix Research (United States)
2006
Tetra- and pentasubstituted polyfunctional dihydropyrroles have been concisely synthesized in high yields by two different processes of the one-pot multicomponent reactions (MCRs) but-2-ynedioates 1, amines 2, aldehydes 3 at room temperature or 70 °C. The first one involves a domino hydroamination/nucleophilic addition/amidation-cyclization process leads to formation tetrasubstituted 4. second undergoes hydroamination/amidation/intramolecular cyclization/imine-enamine tautomerization...
Critical micelle concentration (CMC) is a crucial parameter of widely used surfactants, and many methods have been developed for CMC determination. However, the current determination, such as conductive, surface tension, fluorometric methods, are tedious time- sample-consuming because series samples with different concentrations surfactants need to be prepared measured. Although an economical, simple, fast titration method determination (only one sample several minutes needed) was reported...
Total body irradiation combined with chemotherapy is currently the most effective procedure as a preparative myeloablative regimen. However, resistance to radiotherapy and in refractory acute myeloid leukemia associated short-time recurrence after allogeneic hematopoietic stem cell transplantation. To address this issue, we used three lines, HL60, HL60/ADR (adriamycin-resistant cells), HL60/RX (a radiation-resistant line established from HL60 cellular models investigate mechanism of Hedgehog...
The critical micelle concentration (CMC) is an important parameter of widely used surfactants and needs to be measured in the application development surfactants. Fluorometric method a determining CMC values owing advantages highly sensitivity, fast response wide range. There are two common methods (I II) preparing samples for fluorometric determination. In process developing probes with aggregation-induced emission (AIE) characteristics, we found that I II were not suitable AIE...
A novel and convenient one-pot synthesis of multisubstituted pyrimidine analogues via multicomponent reactions is disclosed. This catalyst-free domino reaction proceeded smoothly in good to excellent yields offered several other advantages including short time, a simple experimental workup procedure, no toxic byproduct. In addition, the obtained products our experiments are interesting nitrogen heterocyclic molecules containing α- β-amino acid blocks.
A sensitive and visible fluorescence-turn-on probe for the critical micelle concentration (CMC) determination of ionic surfactants has been developed based on practically no emission in micelles but strong aggregation-induced solution racemate tetrahydropyrimide THP-1. CMC values were determined via inflexion with strongest fluorescence intensity.
Racemic low-conjugated non-emissive THPs <bold>1–3</bold> can form highly emissive <italic>RS</italic>- and <italic>RR</italic>/<italic>SS</italic>-packing polymorphs with mixed through-bond through-space conjugation.
We previously reported the novel efficient proton/heat-promoted four-component reactions (4CRs) of but-2-ynedioates, two same/different primary amines, and aldehydes for synthesis tetra- pentasubstituted polyfunctional dihydropyrroles. If aromatic aliphatic amines were used as reagents, four different series products should be obtained via permutation combination amines. However, only three/two rather tetra-/pentasubstisuted dihydropyrroles could prepared 4CRs. Herein, Cu(OAc)2·H2O, a Lewis...
Abstract A new series of C‐6 unsubstituted tetrahydropyrimidines 6 have been directly synthesized via a convenient urea‐catalyzed chemoselective five‐component reaction (5CR) under mild conditions. Compounds show typical aggregation‐induced emission enhancement (AIEE) characteristics because they are practically no emissive in solution but emit blue or green fluorescence aggregates with yield up to 93 %. One the 5CR products, aa , exhibits blue‐ and green‐fluorescence (bf‐ gf‐aggregates)....
Organic fluorophores have attracted great interest owing to their wide applications. They usually contain an electron-conjugated system with aromatic moiety and show high emission in dilute solutions but weaker or even no upon aggregation. Here, a simple one-pot, three-component reaction (3CR) (method I) for the synthesis of various di- monosubstituted aminomaleimides (DAMIs MAMIs) has been developed, reported 3CR II) found be efficient only MAMIs R2 = alkyl. Twelve AMIs were designed...
Photosensitizers play a critical role in photodynamic therapy (PDT). Multifunctional organic nanoparticles (NPs) that possess bright fluorescence aggregates, high singlet oxygen (1O2) quantum yield, near-infrared (NIR) absorption and emission, large Stokes shift, two-photon bioimaging, specific organelle targeting, PDT efficiency, as well good biocompatibility photostability are ideal candidate photosensitizers for image-guided PDT. Due to its enhanced 1O2 generation efficiency aggregate...
Achiral TTHPs except 5k aggregate via N1-inversion-based racemates, and inter-enantiomer cofacial π-stacking abnormally enhances Φ SF values significantly.
This paper proposes a high-voltage direct current (HVDC) overhead-line transmission system with embedded energy storage (ESS) to address the challenges posed by large-scale renewable over long-distance. The is designed provide power support, suppress fluctuations, and clear DC faults effectively. An innovative grid-stabilizing converter (GSC) an integrated ESS, comprising new submodules (SMs), installed in both rectifier inverter stations. includes analysis of operating principle proposed...
Based on the reactive behaviour of substrates, two synthetic routes to polysubstituted pyrimidine derivatives are presented herein: 1) A catalyst-free multicomponent reaction electron-deficient alkynes, aliphatic amines and formaldehyde 2) Ag(I)-catalyzed synthesis pyrimidines from anilines by a domino reaction. Under optimized conditions, reactions were accomplished with high regioselectivity excellent yields. computational study was carried out using B3LYP density functional theory...
Highly functionalized multisubstituted 1,4-dihydropyridines 5 have been concisely synthesized in moderate to good yields viaL-proline-catalyzed one-pot multicomponent reactions (MCRs) of alkynoates or alkynones 1, amines 2, β-dicarbonyl compounds 3 and aldehydes 4 under mild conditions. The MCR process involves hydroamination/Knoevenagel condensation/Michael-type addition/intramolecular cyclization processes leads the formation 5. molecular structure 5ckaa was confirmed by single-crystal...
Polymorphs <bold>1b</bold>/<bold>1c</bold> show unusual sensitive and reversible thermo-stimulus solid-state fluorescence-colour/on–off switching in different temperature ranges.