A5113986832- Immune cells in cancer
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Cardiac Ischemia and Reperfusion
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Vagus Nerve Stimulation Research
- Signaling Pathways in Disease
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Cell death mechanisms and regulation
- Virus-based gene therapy research
- Cardiovascular Function and Risk Factors
- interferon and immune responses
- Epilepsy research and treatment
- T-cell and B-cell Immunology
Northwestern University
2012-2025
Xiamen University
2010-2025
Second Xiangya Hospital of Central South University
2018-2025
Central South University
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Zhujiang Hospital
2013-2025
Southern Medical University
2016-2025
China Medical University
2025
Xi'an Jiaotong University
2014-2024
Chinese PLA General Hospital
2024
We have cloned and characterized a new member of the p38 group mitogen-activated protein kinases here termed p38δ. Sequence comparisons revealed that p38δ is approximately 60% identical to other three isoforms but only 40–45% kinase family members. It contains TGY dual phosphorylation site present in all members activated by extracellular stimuli including cytokines environmental stresses also activate known isoforms. However, unlike isoforms, activity not blocked pyridinyl imidazole,...
Members of the MEF2 family transcription factors bind as homo- and heterodimers to site found in promoter regions numerous muscle-specific, growth- or stress-induced genes. We showed previously that transactivation activity MEF2C is stimulated by p38 mitogen-activated protein (MAP) kinase. In this study, we examined potential role MAP kinase pathway regulating other members. MEF2A, but not MEF2B MEF2D, a substrate for p38. Among four group members, most potent MEF2A. Threonines 312 319...
The p38 group of kinases belongs to the mitogen-activated protein (MAP) kinase superfamily with structural and functional characteristics distinguishable from those ERK, JNK (SAPK), BMK (ERK5) kinases.Although there is a high degree similarity among members in terms structure activation, each member appears have unique function.Here we show that activation p38␥ (also known as ERK6 or SAPK3), but not other isoforms, required for ␥-irradiation-induced G 2 arrest.Activation MKK6-p38␥ cascade...
Reduced capacity to produce ROS increases the severity of T cell-dependent arthritis in both mice and rats with polymorphisms neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since cells cannot exert oxidative burst, we hypothesized that cell responsiveness is downregulated by produced APCs. Macrophages have highest burst among APCs, so study effect macrophage on activation, developed transgenic expressing functional Ncf1 restricted macrophages. Macrophage-restricted expression restored...
Abstract Aims Cardiac hypertrophy is characterized by a shift in metabolic substrate utilization, but the molecular events underlying remodelling remain poorly understood. We explored and mitochondrial dysfunction cardiac investigated cardioprotective effects of choline. Methods results The experiments were conducted using model ventricular partially banding abdominal aorta Sprague Dawley rats. Cardiomyocyte size fibrosis significantly increased hypertrophic hearts. In vitro cardiomyocyte...
Abstract Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows after TBI, injured neurons, mainly those in hippocampus, release osteogenic microRNA (miRNA)-enriched small extracellular vesicles (sEVs), which targeted osteoprogenitors to stimulate formation. We show miR-328a-3p and miR-150-5p, enriched sEVs promote osteogenesis by directly targeting 3′UTR of FOXO4 or CBL ,...
Big mitogen-activated protein (MAP) kinase (BMK1), a member of the mammalian MAP family, is activated by growth factors. The activation BMK1 required for factor-induced cell proliferation and cycle progression. We have previously shown that regulates c-<i>jun</i> gene expression through direct phosphorylation transcription factor MEF2C. MEF2C belongs to myocyte enhancer 2 (MEF2) four-membered family factors denoted MEF2A, -2B, -2C, -2D. Here, we demonstrate that, in addition MEF2C,...
Cancer immunotherapy has been a favorable strategy for facilitating antitumor immunity. However, immune tolerance and an ultimate immunosuppressive tumor microenvironment (ITM) are primary obstacles. To achieve the goals of remodeling ITM promoting cancer immunotherapy, versatile nanoparticle codelivering shikonin (SK) PD-L1 knockdown siRNA (SK/siR-NPs) was reported. SK/siR-NPs demonstrated to tellingly induce immunogenic cell death (ICD) cells, leading increased dendritic maturation....
Abstract Background Gliomas account for the majority of fatal primary brain tumors, and there is much room research in underlying pathogenesis, multistep progression glioma, how to improve survival. In our study, we aimed identify potential biomarkers or therapeutic targets glioma study mechanism tumor progression. Methods We downloaded microarray datasets (GSE43378 GSE7696) from Gene Expression Omnibus (GEO) database. Then, used weighted gene co-expression network analysis (WGCNA) screen...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiphase structure of segmented polyurethanes: effects hard-segment flexibilityYingjie Li, Zhiyong Ren, Ming Zhao, Huichang Yang, and Benjamin ChuCite this: Macromolecules 1993, 26, 4, 612–622Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ma00056a010https://doi.org/10.1021/ma00056a010research-articleACS PublicationsRequest reuse...
p239 is a virus-like particle constituted from hepatitis E virus (HEV) recombinant proteins. It can be used as surrogate for HEV and an investigative tool to study cellular interactions because of its ability adsorb penetrate HepG2 membranes. Our objective was use define the role capsid proteins during early stages infection. Pull-down MALDI-TOF MS experiments identified three host-cell proteins, Grp 78/Bip, α-tubulin heat-shock protein 90 (HSP90), latter investigated further. Antibodies...
The aim of the study was find out whether neuronal mitochondrial injury does take place in severe shock and to explore effective therapy for shock.Rats were divided following group: sham, + normal saline (NS), cyclosporine A (CsA), resveratrol (Res) polydatin (PD). Rats subjected 2 h, followed by administration NS, CsA, Res PD, infusion shed blood. Morphology, metabolism function mitochondria measured.Increased lipid peroxides (LPO) levels, lysosomal permeability transition pore opening took...
Connective tissue growth factor (CTGF) has different roles in types of cancer. However, the involvement and molecular basis CTGF tumor progression prognosis human nasopharyngeal carcinoma (NPC) have almost never been reported. In this study, we observed that downregulated expression was significantly associated with NPC poor prognosis. Knockdown markedly elevated ability cell proliferation vivo vitro. Subsequently, discovered reduction increased miR-18b, an oncomir-promoting proliferation....
Background: Excessive activation of matrix metalloproteinase 9 (MMP-9) has been found in several inflammatory diseases. Previous studies have shown that acetylcholine (ACh) reduced the levels pro-inflammatory cytokines and decreased tissue damage. Therefore, this study was designed to explore potential effects mechanisms ACh on MMP-9 production cell migration response lipopolysaccharide (LPS) stimulation RAW264.7 cells. Methods: expression activity were induced by LPS cells, examined...