A5078732636- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Biosensors and Analytical Detection
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 detection and testing
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- Liver Diseases and Immunity
Xiamen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Nanjing Medical University
2025
Northeast Agricultural University
2025
National Vaccine and Serum Institute
2025
First Affiliated Hospital Zhejiang University
2010-2024
Zhejiang University
2024
China Earthquake Administration
2024
MRC Laboratory of Molecular Biology
2024
Fujian Medical University
2008-2023
Abstract Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. antibody response in infected patients remains largely unknown, and the clinical value of testing has not been fully demonstrated. Methods 173 with infection were enrolled. Their serial plasma samples (n = 535) collected during hospitalization tested for total antibodies (Ab), IgM, IgG against SARS-CoV-2. dynamics disease progress analyzed. Results Among patients, seroconversion rates Ab, 93.1%, 82.7%, 64.7%,...
Designer Vaccine Respiratory syncytial virus (RSV) is one of the last remaining childhood diseases without an approved vaccine. Using a structure-based approach, McLellan et al. (p. 592 ) designed over 150 fusion glycoprotein variants, assessed their antibody reactivity, determined crystal structures stabilized and measured ability to elicit protective responses. This approach yielded immunogen that elicits higher responses than postfusion form glycoprotein, which current leading RSV vaccine...
The prefusion state of respiratory syncytial virus (RSV) fusion (F) glycoprotein is the target most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies that were substantially more potent than prophylactic antibody palivizumab. cocrystal structure for one these antibodies, D25, complex with F revealed D25 to lock by binding a quaternary epitope at trimer apex. Electron microscopy...
Preparedness for a possible influenza pandemic caused by highly pathogenic avian A subtype H5N1 has become global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened concern. It remains unknown from where strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia China. Here, we report that genetically antigenically distinct sublineages established poultry different geographical regions Asia,...
Background Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics complement value the antibody test to RNA need be demonstrated. Method Serial sera 80 patients with PCR-confirmed disease 2019 (COVID-19) were collected at First Affiliated Hospital Zhejiang University, Hangzhou, China. Total (Ab), IgM IgG antibodies against SARS-CoV-2 detected, dynamics during described. Results...
Hepatitis B virus (HBV) RNA in serum has recently been linked to efficacy and prognosis of chronic hepatitis (CHB) treatment. This study explored the nature, origin, underlying mechanisms, potential clinical significance HBV RNA.The levels DNA were determined supernatant induced HepAD38, HBV-expressing HepG2.2.15 cells primary human hepatocytes (PHH), transgenic mice CHB patients. NP-40 proteinase K treatment, sucrose density gradient centrifugation, electron microscopy, northern blot,...
Hepatitis E virus (HEV) is a leading cause of acute hepatitis. The long-term efficacy hepatitis vaccine needs to be determined.In an initial study, we randomly assigned healthy adults 16 65 years age receive three doses either (vaccine group; 56,302 participants) or B (control participants). vaccines were administered at 0, 1, and 6 months, the participants followed for 19 months. In this extended follow-up treatment assignments all remained double-blinded, assessments efficacy,...
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor kinase MST1/2 provides therapeutic option for tissue injury repair.
Summary Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. antibody response in infected patient remains largely unknown, and the clinical values of testing have not been fully demonstrated. Methods A total 173 patients with confirmed infection were enrolled. Their serial plasma samples (n = 535) collected during hospitalization period tested for antibodies (Ab), IgM IgG against using immunoassays. dynamics progress severity disease was analyzed. Results Among patients,...
Background: The novel coronavirus SARS-CoV-2 is a newly emerging virus. antibody response in infected patient remains largely unknown, and the clinical values of testing have not been fully demonstrated.Methods: A total 173 patients with confirmed infection were enrolled. Their serial plasma samples (n = 535) collected during hospitalization period tested for antibodies (Ab), IgM IgG against using immunoassays. dynamics progress severity disease was analyzed.Findings: Among patients,...
Abstract All hepatitis E virus (HEV) variants reported to infect humans belong the species Orthohepevirus A (HEV-A). The zoonotic potential of C (HEV-C), which circulates in rats and is highly divergent from HEV-A, unknown. We report a liver transplant recipient with caused by HEV-C infection. detected RNA multiple clinical samples antigen liver. complete genome isolate had 93.7% nt similarity an strain Vietnam. patient preexisting HEV antibodies, were not protective against Ribavirin was...
The global pandemic of coronavirus disease 2019 (COVID-19) is a disaster for human society. A convenient and reliable neutralization assay very important the development vaccines novel drugs. In this study, G protein-deficient vesicular stomatitis virus (VSVdG) bearing truncated spike protein (S with C-terminal 18 amino acid truncation) was compared to that full-length SARS-CoV-2 showed much higher efficiency. established based on VSV-SARS-CoV-2-Sdel18 pseudovirus hACE2-overexpressing BHK21...
Remarkable progress has been made in developing intramuscular vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with respect to eliciting local immunity the tract, which is primary infection site for SARS-CoV-2. To overcome limitations of vaccines, we constructed a nasal vaccine candidate based on an influenza vector by inserting gene encoding receptor-binding domain (RBD) spike protein SARS-CoV-2, named CA4-dNS1-nCoV-RBD (dNS1-RBD). A...
Population screening of asymptomatic persons with Epstein–Barr virus (EBV) DNA or antibodies has improved the diagnosis nasopharyngeal carcinoma and survival among affected persons. However, positive predictive value current strategies is unsatisfactory even in areas where endemic. We designed a peptide library representing highly ranked B-cell epitopes EBV coding sequences to identify novel serologic biomarkers for carcinoma. After retrospective case–control study, performance biomarker...