A5100457463- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Perovskite Materials and Applications
- Polydiacetylene-based materials and applications
- RNA Interference and Gene Delivery
- Synthesis and Properties of Aromatic Compounds
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Adenosine and Purinergic Signaling
- Ocular Oncology and Treatments
- Advanced Photocatalysis Techniques
- Liquid Crystal Research Advancements
- Extracellular vesicles in disease
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Wound Healing and Treatments
- melanin and skin pigmentation
- Circular RNAs in diseases
Chinese Academy of Sciences
2013-2025
Xingtai People's Hospital
2025
Hebei Medical University
2022-2025
Sichuan University
2022-2025
Stomatology Hospital
2025
Air Force Medical University
2025
Nanning Normal University
2024
Shenzhen University
2020-2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2022-2024
Shanghai Jiao Tong University
2022-2024
Abstract Non-invasive visualization of dynamic molecular events in real-time via imaging may enable the monitoring cascade catalytic reactions living systems, however effective modalities and a robust reaction system are lacking. Here we utilize three-dimensional (3D) multispectral photoacoustic (PA) to monitor vivo therapy based on dual enzyme-driven cyclic platform. The consists two-dimensional (2D) Pd-based nanozyme conjugated with glucose oxidase (GOx). combination GOx can induce PA...
Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal...
Retinoblastoma (RB) is prone to delayed diagnosis or treatment and has an increased likelihood of metastasizing. Thus, it crucial perform effective imaging examination provide optimal RB prevent metastasis. Nanoparticles that support diagnostic targeted therapy are expected noninvasively integrate tumor treatment. Herein, we report a multifunctional nanoparticle for multimodal imaging-guided low-intensity focused ultrasound (LIFU)/immunosynergistic therapy. Magnetic hollow mesoporous gold...
Retinoblastoma (RB) is a malignant intraocular neoplasm that occurs in children. Diagnosis and therapy are frequently delayed, often leading to metastasis, which necessitates effective imaging treatment. In recent years, the use of nanoplatforms allowing both targeted treatment has attracted much attention. Herein, we report novel nanoplatform folate-receptor (FR) laser-activatable liposome termed FA-DOX-ICG-PFP@Lip, loaded with doxorubicin (DOX)/indocyanine green (ICG) liquid...
Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has emerged as a better candidate for deep-tissue tumor elimination. More interestingly, photothermal ablated cells also manifest somewhat immunostimulation potency to elicit antitumor immunity, although most dying are undergoing apoptosis that is commonly considered immunologically silent. Here, NIR-II responsive nanosystem established photoimmunotherapy using molybdenum dioxide (MoO2) nanodumbbells nanoconverter....
Abstract Due to the complicated tumor microenvironment that compromises efficacies of various therapies, effective treatment pancreatic cancer remains a big challenge. Sono‐activatable semiconducting polymer nanoreshapers (SPN DN H) are constructed multiply remodel orthotopic for potent immunotherapy. SPN H contain polymer, hydrogen sulfide (H 2 S) donor, and indoleamine 2,3‐dioxygenase (IDO) inhibitor (NLG919), which encapsulated by singlet oxygen ( 1 O )‐responsive shells with modification...
Heptamethine cyanines (Cy7) are one of the most important dyes in bioimaging and phototherapy, but they often suffer from poor photostability or limited photothermal conversion efficiency. Here, a facile molecular engineering approach to regulating photophysical properties Cy7 by metal ions is demonstrated. By innovatively modifying nitrogen with functional groups, novel terpyridine-grafted nitrogen-terminated scaffold (denoted as CydtPy) was synthesized exhibited tunable when chelating...
Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell....
We demonstrate for the first time that PPy–SiO2–GTA composites can be used as efficient photothermal agents killing pathogenic bacteria under NIR irradiation. The cell growth of both gram-positive and gram-negative targeted by could inhibited effectively after treatment.
Conducting crystallization-assisted self-assembly in living biosystems to obtain large-size nanoparticles and achieve a specific physiological purpose remains an appealing yet significantly challenging task. In this study, we designed Au(I)-disulfide nanosheets containing aggregation-induced emission photosensitizer, namely, NSs@TTVP, which exhibited pH-responsive crystallization-driven capability lysosomes of cancer cells tumor tissues mice. The crystallization process endowed NSs@TTVP with...
Osteosarcoma (OS) is one of the most common bone malignant tumors which mainly develops in adolescents. Although neoadjuvant chemotherapy has improved prognosis patients, numerous chemotherapeutic challenges still limit their use. Here, inspired by Watson-Crick base pairing nucleic acids, hydrophobic (methotrexate) and hydrophilic (floxuridine) chemo-drugs are mixed self-assembled into M:F nanoparticles (M:F NPs) through molecular recognition. Then, obtained NPs co-extruded with membranes...
Highly efficient recognition of cancer cells by immune is important for successful therapeutic-cell-based immunotherapy. Herein, we present a facile NIR-II nanoadaptor [hyaluronic acid (HA)/dibenzocyclooctyne (DBCO)-Au:Ag2Te quantum dots (QDs)] enhancing the tumor and binding ability natural killer (NK) via bio-orthogonal click reaction in vivo. The Nanoadaptor possesses superior tumor-targeting capacity, facilitating accumulation chemical receptor DBCO at sites. Subsequently, enrichment on...
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing screen molecules mediating identified METTL14 as determinant of sensitivity. Clinical samples datasets were analyzed in vitro vivo experiments performed...
Introduction: Ovarian Cancer (OC) was known for its high mortality rate among gynecological malignancies, often resulting in a poor prognosis. This study sought to identify prognostic necroptosis-related long non-coding RNAs (lncRNAs) (NRlncRNAs) with potential and construct reliable risk prediction model OC patients. Method: The transcriptome clinic data were sourced from TCGA GTEx databases. Initially, NRlncRNAs discovered by assessing gene correlations evaluating differences expression....
Abstract Dynamic therapy utilizes reactive oxygen species (ROS) to antibacterial and enhance the innate immune system treat bacterial infections. If ROS levels are too low, elimination of pathogens enhancement immunity cannot be achieved. However, excess accumulation may impact intracellular glutathione (GSH) levels, hindering T cell maturation establishment memory. Herein, a multifunctional nanofiber membrane is designed, consisting polymer scaffold, MXene/CeO 2 bio‐heterojunctions (MX@Ce...
A pair of axially chiral thermally activated delayed fluorescent (TADF) enantiomers, R‐TCBN‐ImEtPF6 and S‐TCBN‐ImEtPF6, with intrinsic ionic characteristics were efficiently synthesized by introducing imidazolium hexafluorophosphate to TADF unit. The salts exhibited a high photoluminescence quantum yield (PLQY) up 92%, small singlet–triplet energy gap (∆EST) 0.04 eV, as well reversible redox properties. Furthermore, the enantiomers showed distinct mirror‐image CD CPL activities glum values...
Construction of tumor microenvironment responsive probe with more than one imaging modality, in particular toward hypoxia solid tumors, is an appealing yet significantly challenging task. In this work, we designed a hypoxia-activated TBTO (Triphenylamine-Benzothiadiazole-Triphenylamine derivative featuring four diethylamino N-Oxide groups) for vivo imaging. could undergo bioreduction hypoxic to yield compound TBT sharing both near-infrared (NIR) aggregation-induced emission and strong...
Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives quality life. Early diagnosis treatment can save vision as much possible. Multifunctional nanoparticles have become a research hotspot in recent years are expected to realize the integration early treatment. Therefore, we report nanoparticle with dual-mode imaging, photothermal therapy, immune activation: carbonized MOF (CM NPs) loaded polypeptide tuftsin (CMT NPs). The imaging ability,...
Circularly polarized electroluminescence (CPEL) is highly promising in realm of 3D display and optical data storage. However, designing a groundbreaking chiral material with high comprehensive CPEL performance remains formidable challenge. In this work, pair polymers self-assembled behavior designed by integrating BN-moiety into polyfluorene backbone, named R-PBN S-PBN, respectively. The show narrowband emission centered at 490 nm full-width half maximum (FWHM) 29 photoluminescence quantum...