Hits the dot: Ag(2)S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating were synthesized for in vivo small-animal imaging. The 6PEG-Ag(2)S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to long circulation half-life 4 h. Clearance occurs mainly through biliary pathway mice.

Ag2S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0–1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for first time. Highly selective vitro targeting imaging of different cell lines achieved using biocompatible NIR-II QDs ligands. The cytotoxicity study illustrates negligible effects altering proliferation, triggering apoptosis necrosis, generating reactive oxygen species, causing DNA damage....

High-performance electrocatalysts with superior stability are critically important for their practical applications in hydrogen evolution reaction (HER) and oxygen reduction (ORR). Herein, we report a facile method to fabricate urchin-like CoP nanocrystals (NCs) as catalyst both HER ORR desirable electrocatalytic activities long-term stability. The NCs diameter of 5 μm were successfully prepared by hydrothermal following phosphidation treatment N2 atmosphere present excellent catalytic...

Tuning the crystal phase of metal alloy nanomaterials has been proved a significant way to alter their catalytic properties based on structure and electronic property. Herein, we successfully developed simple strategy controllably synthesize rare hexagonal close-packed (hcp) NiFe nanoparticle (NP) encapsulated in N-doped carbon (NC) shell (hcp-NiFe@NC). Then, systemically investigated oxygen evolution reaction (OER) performance samples under alkaline conditions, which hcp-NiFe@NC exhibits...

A facile solvothermal method is reported to synthesize highly photoluminescent Ag2Se quantum dots (QDs) with emission at 1300 nm in the second near-infrared window. After surface modification of C18-PMH-PEG, QDs possess bright photoluminescence, good water-solubility, high colloidal stability and photostability, as well decent biocompatibility, which are further successfully performed vivo deep imaging organs vascular structures spatial resolution. This new NIR-II fluorescent nanoprobe small...

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores for<italic>in vivo</italic>tumor imaging and image-guided sentinel lymph node surgery.

Ag2S quantum dots (QDs) have attracted increasing attention due to their appealing optical properties in the near-infrared regime. However, a full understanding of confinement effect QDs has not been achieved so far. Herein, for first time, size-dependent excited state are systematically investigated by photoluminescence (PL), PL excitation (PLE), and time-resolved spectroscopy. Experimentally, we determine exciton Bohr radius as 2.2 nm, which is highly consistent with theoretical results.

Stem cell therapeutics has emerged as a novel regenerative therapy for tissue repair in the last decade. However, dynamically tracking transplanted stem cells vivo remains grand challenge cell‐based regeneration medicine full understanding function and fate of cells. Herein, Ag 2 S quantum dots (QDs) second near‐infrared window (NIR‐II, 1.0–1.4 μm) are employed human mesenchymal (hMSCs) with high sensitivity spatial temporal resolution. As few 1000 QDs‐labeled hMSCs detectable their...

Abstract Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis real‐time feedback on pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&amp;A@Ag 2 S) second near‐infrared window (NIR‐II) presented for vivo optical imaging TBI. Initially, fluorescence V&amp;A@Ag S turned off owing energy transfer from Ag A1094 chromophore. Upon intravenous...

Semiconductor quantum dots (QDs) with photoluminescence (PL) emission at 900–1700 nm (denoted as the second near-infrared window, NIR-II) exhibit much-depressed photon absorption and scattering, which has stimulated extensive researches in biomedical imaging NIR devices. However, it is very challenging to develop NIR-II QDs a high yield (PLQY) excellent biocompatibility. Herein, we designed synthesized an alloyed silver gold selenide (AgAuSe) QD bright from 820 1170 achieved record absolute...

Effective drug delivery in the central nervous system (CNS) needs to have long blood-circulation half-lives, pass through blood–brain barrier (BBB), and subsequently be taken up by target cells. Herein, a traceable CNS nanoformulation (RVG-NV-NPs) is developed encapsulating bexarotene (Bex) AgAuSe quantum dots (QDs) within Lamp2b-RVG-overexpressed neural stem cell (NSC) membranes. The high-fidelity near-infrared-II imaging QDs offers possibility of vivo monitoring multiscale process from...

Uniform ultralarge single crystal SnS rectangular nanosheets (7000 nm × 3000 20 nm) have been synthesized by thermodecomposing a single-source precursor (Sn-diethyldithiocarbamate-1,10-phenanthroline). The obtained exhibit excellent electrochemical properties which promising applications in lithium ion batteries.

Protein nanocages (PNCs) have been recognized as a promising platform for nanomedicine innovation. Real-time in vivo tracking of PNCs can provide critically important information the development PNC-based diagnostics and therapeutics. Here we demonstrate general strategy monitoring behaviors by encapsulating Ag2S quantum dot (QD) with fluorescence second near-infrared window (NIR-II, 1000–1700 nm) inside PNC, using simian virus 40 (SV40) PNC (PNCSV40) model. Benefiting from high...

Rational design of cost‐effective, nonprecious metal‐based catalysts with desirable oxygen reduction reaction (ORR) performance is extremely important for future fuel cell commercialization, etc. Herein, a new type ORR catalyst Co‐N‐doped mesoporous carbon hollow sphere (Co‐N‐mC) was developed by pyrolysis from elaborately fabricated polystyrene@polydopamine‐Co precursors. The obtained active Co sites distributed in highly graphitized N‐doped spheres exhibited outstanding activity an onset...

Heterostructured semiconductor matchsticks with Ag2S heads and ZnS stems (see TEM image) were synthesized by thermal co-decomposition of Ag(DDTC) Zn(DDTC)2 (DDTC=diethyldithiocarbamate). The heteronanostructures show both UV/blue (λex=280 nm) near-infrared (λex=785 photoluminescence. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted the authors. Please note:...

In clinical practice, it is difficult to identify tumor margins during brain surgery due its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) reported, which integrates advantages of the deep tissue penetration enhanced magnetic resonance (MR) imaging Gd and high signal-to-noise ratio spatiotemporal resolution fluorescence in second near-infrared window (NIR-II) Ag2S quantum dots (QDs). Due abundant angiogenesis...

Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, minimal side-effects. Herein, a microenvironment (TME)-activated NIR-II nanotheranostic system (FEAD1) precise treatment of peritoneal metastases is presented. FEAD1 was fabricated by self-assembling the peptide Fmoc-His, mercaptopropionic-functionalized Ag2 S quantum dots (MPA-Ag2 QDs), chemodrug doxorubicin (DOX), NIR absorber A1094 into...

Combined chemotherapy and immunotherapy have demonstrated great potential in cancer treatment. However, it is difficult to provide clear information of the pharmacokinetics pharmacodynamics chemodrugs transplanted immune cells vivo by traditional approaches, resulting inadequate therapy. Here, a multiplexed intravital imaging strategy using fluorescence second near-infrared window (NIR-II) first developed visualize two events vivo, so that combinational administration programed improve...

Auf den Quantenpunkt gebracht: Ag2S-Quantenpunkte mit heller NIR-Fluoreszenz und einer Oberflächenbeschichtung aus verzweigtem PEG (siehe Schema) wurden für die Bildgebung in lebenden Kleintieren synthetisiert. Dank ihrer langen Zirkulationsdauer (ca. 4 h) QDs von Tumoren ungefähr 10 % der injizierten Dosis pro Gramm aufgenommen. Mäuse schieden hauptsächlich über biliären Weg aus.

A novel multifunctional Ag2 S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag2 is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition Ald the chemotherapeutic effect DOX on are situ visualized by QDs with emission second near-infrared window.