A5067030521- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Flame retardant materials and properties
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Nanoparticle-Based Drug Delivery
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Synthesis and properties of polymers
- Mycobacterium research and diagnosis
- Nanopore and Nanochannel Transport Studies
- Photoacoustic and Ultrasonic Imaging
- Metal-Organic Frameworks: Synthesis and Applications
- Polymer composites and self-healing
- Crystallization and Solubility Studies
- Fire dynamics and safety research
- Genomics and Phylogenetic Studies
- X-ray Diffraction in Crystallography
- Biosensors and Analytical Detection
- Asthma and respiratory diseases
- Nanocluster Synthesis and Applications
Zhongnan Hospital of Wuhan University
2018-2025
Sichuan University
2015-2025
Wuhan University
2016-2025
Shanghai Institute of Materia Medica
2022-2025
Chinese Academy of Sciences
2022-2025
China University of Geosciences
2024-2025
West China Hospital of Sichuan University
2015-2025
Fudan University Shanghai Cancer Center
2025
Shanghai Medical College of Fudan University
2025
Brigham and Women's Hospital
2018-2024
Abstract Single atom nonmetal 2D nanomaterials have shown considerable potential in cancer nanomedicines, owing to their intriguing properties and biocompatibility. Herein, ultrathin boron nanosheets (B NSs) are prepared through a novel top‐down approach by coupling thermal oxidation etching liquid exfoliation technologies, with controlled nanoscale thickness. Based on the PEGylated B NSs, new photonic drug delivery platform is developed, which exhibits multiple promising features for...
Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, second near-infrared window (NIR-II, 1000-1700 nm) is at the forefront on optical techniques. Small-molecule based NIR-II (1000-1700 dyes are promising candidates for in vivo molecular because their high biocompatibility, fast excretion, clinical translation ability. However, reports small-molecule probes rare. Herein, we designed series fluorescent compounds (Q1, Q2, Q3, Q4) investigated...
This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores for<italic>in vivo</italic>tumor imaging and image-guided sentinel lymph node surgery.
Loss of function in tumor suppressor genes is commonly associated with the onset/progression cancer and treatment resistance. The p53 gene, a master regulator diverse cellular pathways, frequently altered various cancers, for example, ~36% hepatocellular carcinomas (HCCs) ~68% non-small cell lung cancers (NSCLCs). Current methods restoration expression, including small molecules DNA therapies, have yielded progressive success, but each has formidable drawbacks. Here, redox-responsive...
Abstract NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule been discovered donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted dyes not reported. Herein, we report development of D-A type thiopyrylium-based frequency upconversion luminescence (FUCL) at ~580 nm upon excitation ~850 nm. H4-PEG-PT can only quickly effectively image mitochondria live fixed...
Novel biocompatible NIR-II aggregation-induced emission dots are facilely assembled and used for biomedical fluorescence imaging.
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000–1700 nm) window has gained increasing interest clinical application. Till now, very few studies have been exploited small-molecule fluorophores with both excitation and emission NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes absorption developed for imaging, providing feasibility to directly compare optical NIR-IIa (1300–1400 subwindow under 1064 nm that 808 excitation. The...
Abstract Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated part by the immunosuppressive tumor microenvironment (TME). As p53 loss of function may play a role immunosuppression, we herein examine effects restoring expression on TME ICB efficacy. We develop optimize CXCR4-targeted mRNA nanoparticle platform to effectively induce HCC models. Using -null orthotopic ectopic models murine HCC, find that...
Abstract Biotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis high‐quality BM nanosheets (NSs) remains huge challenge. Here, an exfoliation approach provided that combines calcination, n ‐butyllithium exchange and intercalation, liquid exfoliating processes for the high‐yield ultrathin NSs. Due to presence MgO, Fe 2 O 3 , FeO these NSs, PEGylated can be engineered as intelligent theranostic platform following...
Novel NIR-II organic fluorophores were designed and synthesized using an AIE highly twisted donor–acceptor distortion strategy for bio-imaging beyond 1550 nm.
Fluorescence and photoacoustic (PA) imaging in the second near-infrared (NIR-II, 1000–1700 nm) window has garnered massive interest owing to high maximum permissible exposure of light, reduced autofluorescence, improved deep penetration. However, active targeted NIR-II photoacoustic/NIR-IIa fluorescence glioma under excitation been seldom reported, which is partly ascribable lack suitable materials. In this study, a small-molecule-based αvβ3-targeted fluorescent probe IR-32p was generated...
Aggregation profoundly influences the photophysical properties of molecules. Here, a new series thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, star molecule HTPA exhibits remarkable pH-responsive behavior and significant increase in photoacoustic (PA) intensity when aggregated. Additionally, pH reversibility during formation are systematically investigated, including computational optimization,...
A multifunctional gold nanorod (GNR)-based nanoplatform for targeted anticancer drug delivery and positron emission tomography (PET) imaging of tumors was developed characterized. An anti-cancer (i.e., doxorubicin (DOX)) covalently conjugated onto PEGylated (PEG: polyethylene glycol) GNR nanocarriers via a hydrazone bond to achieve pH-sensitive controlled release. Tumor-targeting ligands the cyclo(Arg-Gly-Asp-D-Phe-Cys) peptides, cRGD) (64)Cu-chelators 1,4,7-triazacyclononane-N, N',...
Accurate tumor identification is essential in cancer management. Incomplete excision of tissue, however, negatively affects the prognosis patient. To accomplish radical radiotracers can be used that target tissue and detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time delineation. Herein, novel dual-modal platform base-catalyzed double addition thiols into propiolamide scaffold has been developed, allowing for highly efficient...
The development of novel biodegradable and nontoxic fluorophores that integrate diagnosis therapy for effective cancer treatment has obtained tremendous attention in the past decades. In this report, water-soluble biocompatible small-molecule near-infrared II (NIR-II) fluorescent dye H2a-4T complexed with fetal bovine serum (FBS) Cetuximab proteins excellent optical properties targeting ability is prepared. High spatial temporal resolution imaging hind limb vasculature lymphatic system...
A multifunctional gold (Au) nanorod (NR)-based nanocarrier capable of co-delivering small interfering RNA (siRNA) against achaete-scute complex-like 1 (ASCL1) and an anticancer drug (doxorubicin (DOX)) specifically to neuroendocrine (NE) cancer cells was developed characterized for combined chemotherapy siRNA-mediated gene silencing. The Au NR conjugated with (1) DOX, drug, via a pH-labile hydrazone linkage enable pH-controlled release, (2) polyarginine, cationic polymer complexing siRNA,...