A5103158588- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Carbon dioxide utilization in catalysis
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Polymer composites and self-healing
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Advanced Polymer Synthesis and Characterization
- Photodynamic Therapy Research Studies
- Photochromic and Fluorescence Chemistry
- Radiopharmaceutical Chemistry and Applications
- Supramolecular Chemistry and Complexes
- Lignin and Wood Chemistry
- Microplastics and Plastic Pollution
- Cancer, Hypoxia, and Metabolism
- Advanced Photocatalysis Techniques
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Fluid Dynamics and Heat Transfer
- Gold and Silver Nanoparticles Synthesis and Applications
- Silicon Nanostructures and Photoluminescence
Dalian University of Technology
2000-2024
Dalian University
2019-2024
State Key Laboratory of Fine Chemicals
2022
Wuhan University
2016
State Key Laboratory of Virology
2016
Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, second near-infrared window (NIR-II, 1000-1700 nm) is at the forefront on optical techniques. Small-molecule based NIR-II (1000-1700 dyes are promising candidates for in vivo molecular because their high biocompatibility, fast excretion, clinical translation ability. However, reports small-molecule probes rare. Herein, we designed series fluorescent compounds (Q1, Q2, Q3, Q4) investigated...
Conventional photocages only respond to short wavelength light, which is a significant obstacle developing efficient phototherapy in vivo. The development of activated by near-infrared (NIR) light at wavelengths from 700 950 nm important for vivo studies but remains challenging. Herein, we describe the synthesis photocage based on ruthenium (Ru) complex with NIR light-triggered photocleavage reaction. commercial anticancer drug, tetrahydrocurcumin (THC), was coordinated RuII center create...
Enzymatic reactions can consume endogenous nutrients of tumors and produce cytotoxic species are therefore promising tools for treating malignant tumors. Inspired by nature where enzymes compartmentalized in membranes to achieve high reaction efficiency separate biological processes with the environment, we develop liposomal nanoreactors that perform enzymatic cascade aqueous nanoconfinement liposomes. The effectively inhibited tumor growth vivo consuming (glucose oxygen) producing highly...
On-demand droplet transportation is of great significance for numerous applications. Although various strategies have been developed transportation, out-of-surface three-dimensional (3D) droplets remains challenging. Here, a versatile strategy based on magnetic-actuated jumping (MAJ) superhydrophobic grooved surfaces (SHGSs) presented, which enables 3D, remote, and precise manipulation even in enclosed narrow spaces. To trigger MAJ, an electromagnetic field utilized to deform the SHGS with...
The dynamic behaviors of vitrimer are influenced by the interaction cross-link density and exchangeable groups, which results in difficulty extracting effect mono-variation. In this study, were tuned changing hydroxyls alone, while leaving undisturbed. A multi-hydroxy network without a loading catalyst was synthesized successfully. Three-armed functionalized polycarbonate, obtained ring-opening polymerization 1,3-dioxan-2-one its derivatives, treated as precursor polymer. Afterward, polymer...
Abstract Photocages enable the precise activation of molecular function with light in many research fields, such as anticancer treatment, where remote spatiotemporal control over release an active drug is needed. However, poor physiological stability and tumor accumulation conventional small photocages are significant obstacles to developing efficient therapy vivo. In this study, a new concept “polyphotocage” proposed through photocage–polymer hybrid macromolecular engineering....
Photoresponsive ruthenium(II) complexes have recently emerged as a promising tool for synergistic photodynamic therapy and chemotherapy in oncology, well antimicrobial applications. However, the limited penetration power of photons prevents treatment deep-seated lesions. In this study, we introduce sonoresponsive ruthenium complex capable generating superoxide anion (O2•–) via type I process initiating ligand fracture upon ultrasound triggering. Attaching hydroxyflavone (HF) an "electron...
The synergistic combination of chemotherapy and photodynamic therapy has attracted considerable attention for its enhanced antitumoral effects; however, it remains challenging to successfully delivery photosensitizers anticancer drugs while minimizing drug leakage at off-target sites. A red-light-activatable metallopolymer, Poly(Ru/PTX), is synthesized combined chemo-photodynamic therapy. polymer a biodegradable backbone that contains photosensitizer Ru complex the paclitaxel (PTX) via...
Abstract Intracellular oxidative amplification can effectively destroy tumor cells. Additionally, Fe‐mediated Fenton reaction often converts cytoplasm H 2 O to generate extensive hypertoxic hydroxyl radical ( • OH), leading irreversible mitochondrion damage for celleradication, which is widely famous as chemodynamic therapy (CDT). Unfortunately, intracellular overexpressed glutathione (GSH) always efficiently scavenges OH, resulting in the significantly reduced CDT effect. To overcome this...
Monoamine oxidase A (MAO-A) is a dimeric flavoprotein that found in the mitochondrial membrane. Currently, there lack of near-infrared fluorescent probes (NIR-FPs) with good specificity and high sensitivity for detecting MAO-A, making it difficult to accurately recognize image cells vitro vivo. In this study, NIR-FP DDM-NH2 was designed synthesized order detect MAO-A specifically live biological systems. The probe comprised two functional components: dicyanoisophosphone as an NIR dye...
Abstract Photodynamic therapy (PDT) has become a promising method for tumor treatment due to its non‐invasive and high spatiotemporal selectivity. However, PDT is still hindered by reactive oxygen species deficiency, because solid tumors feature hypoxic microenvironment. combined with hypoxia‐activated chemotherapy drugs can effectively induce death, overcoming the limitations of sole fight against hypoxia. Herein, we designed nanosystem (PCe6AZOM) that enhances release (AZOM) PDT. Under...
In the current context of sustainable chemistry development and new regulations, aminolysis cyclic carbonate is one most promising routes to nonisocyanate polyurethanes, also called polyhydroxyurethanes (PHU). this study, a kind shape memory PHU vitrimers with outstanding mechanical properties chemical recyclability prepared. The monomer employed for form PHUs bis(six-membered carbonate) 4,4'-biphenol (BCC-BP), which synthesized by bi(1,3-diol) precursors CO2. synthetic strategy,...
Metal-based drugs currently dominate the field of chemotherapeutic agents; however, achieving controlled activation metal prodrugs remains a substantial challenge. Here, we propose universal strategy for radiation-triggered via nanosurface energy transfer (NSET). The core-shell nanoplatform (Ru-GNC) is composed gold nanoclusters (GNC) and ruthenium (Ru)-containing organic-inorganic hybrid coatings. Upon X-ray irradiation, Ru (II) complexes were released in manner through unique NSET process...
The lack of selectivity between tumor and healthy cells, along with inefficient reactive oxygen species production in solid tumors, are two major impediments to the development anticancer Ru complexes. photoinduced combination therapy based on biodegradable polymers that can be light activated "therapeutic window" would beneficial for enhancing therapeutic efficacy Herein, a Ru-containing polymer (poly(DCARu)) is developed, which different therapeutics (the drug complex) rationally...
The clinical application of photodynamic therapy (PDT) has some limitations including poor tumor targeting properties, a high reductive microenvironment, and inefficient activation single cell death machinery. We herein report pH-sensitive polymeric nanomodulators (NBS-PDMC NPs) for ferroptosis-enhanced therapy. NBS-PDMC NPs were constructed using positively charged type-I photosensitizer (NBS) coordinated with demethylcantharidin (DMC)-decorated block copolymer via electrostatic...