A5037750757- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Pharmaceutical Practices and Patient Outcomes
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Patient Safety and Medication Errors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Pharmaceutical studies and practices
- Lung Cancer Research Studies
- Chemotherapy-induced organ toxicity mitigation
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Pharmacy and Medical Practices
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
Mudanjiang Medical University
2025
Hebei Medical University
2018-2025
University of Bristol
2025
Jiangsu Province Hospital
2025
Nanjing University of Chinese Medicine
2025
First Affiliated Hospital of Hebei Medical University
2025
Second Affiliated Hospital of Zhejiang University
2013-2024
West China Hospital of Sichuan University
2018-2024
Sichuan University
2010-2024
Sichuan Cancer Hospital
2020-2024
Abstract Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated part by the immunosuppressive tumor microenvironment (TME). As p53 loss of function may play a role immunosuppression, we herein examine effects restoring expression on TME ICB efficacy. We develop optimize CXCR4-targeted mRNA nanoparticle platform to effectively induce HCC models. Using -null orthotopic ectopic models murine HCC, find that...
Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction.As a major mechanism for cellular self-degradation, autophagy has been proven protect against cisplatin-induced acute kidney injury (AKI).Based on the activation of induced trehalose, we aimed investigate nephroprotective effects trehalose AKI and its underlying mechanisms.Results: Due autophagy, dysfunction (mitochondrial fragmentation, depolarization, reactive oxygen species (ROS),...
Abstract: Although the frequency of bone metastases from breast cancer has increased, effective treatment is lacking, prompting development nanomedicine, which involves use nanotechnology for disease diagnosis and treatment. Nanocarrier drug delivery systems offer several advantages over traditional methods, such as higher reliability biological activity, improved penetration retention, precise targeting delivery. Various nanoparticles that can selectively target tumor cells without causing...
Abstract Intrahepatic cholangiocarcinoma (ICC) has limited therapeutic options and a dismal prognosis. Adding blockade of the anti–programmed cell death protein (PD)-1 pathway to gemcitabine/cisplatin chemotherapy recently shown efficacy in biliary tract cancers but with low response rates. Here, we studied effects anti–cytotoxic T lymphocyte antigen (CTLA)-4 when combined anti–PD-1 orthotopic murine models ICC. This combination therapy led substantial survival benefits reduction morbidity...
Background: Medication errors may occur during prescribing, transcribing, prescription auditing, preparing, dispensing, administration, and monitoring. administration (MAEs) are those that actually reach patients remain a threat to patient safety. The Joint Commission International (JCI) advocates medication error prevention, but experience in reducing MAEs the period of before after JCI accreditation has not been reported. Methods: An intervention study, aimed at hospitalized patients, was...
Aims: Clinical use of cisplatin (Cisp), one the most widely used, common, and effective chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Previous studies suggest that hydrogen sulfide (H2S) alleviates Cisp-induced acute kidney injury (AKI). However, underlying mechanism remains largely unclear. Results: A single intraperitoneal injection Cisp employed to induce AKI, mice exhibit severe dysfunction histological damage at day 4...
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Chronic inflammation recognized as key causal factor in the development and progression DN, imbalance M1/M2 macrophages (Mφ) contributes to this process. Mesenchymal stem cells (MSCs) have been reported prevent injuries via immune regulation diabetic models, but whether these benefits are owing Mφ, underlying signaling pathways unknown. Here, we showed that MSCs elicited Mφ into M2 phenotype prevented DN mice, effects...
Ferroptosis is a type of cell death characterized by iron-dependent phospholipid peroxidation and reactive oxygen species overproduction. induces immunogenic elicits anti-tumor immune responses, playing an important role in cancer immunotherapy. suppression cells impairs its immunotherapeutic efficacy. To overcome this issue, ferroptosis inducers (FINs) have been combined with other therapies to create microenvironment. However, the ferroptosis-based crosstalk between tumor complex because...
We recently reported that intermittent hypoxia facilitated the proliferation of neural stem/progenitor cells (NPCs) in subventricule zone and hippocampus vivo . Here, we demonstrate promoted NPCs vitro hypoxia‐inducible factor (HIF)‐1α, which is one key molecules response to hypoxia, was critical this process. were isolated from rat embryonic mesencephalon (E13.5), exposed different oxygen concentrations (20% O 2 , 10% 3% ) for 3 days. The results showed especially as assayed by...
Background: Skeletal muscle relaxants (SMRs) are widely used in treating musculoskeletal conditions.All SMRs, with the exception of baclofen and tizanidine, on list 2023 American Geriatrics Society Beers Criteria ® for potentially inappropriate medication use older adults.In our geriatric practice, off-label tizanidine as preemptive analgesia drove us to find recent advances its pharmacology therapeutics.An update review was thus presented, aiming bring latest knowledge clinicians promote...
Abstract Background Antibiotic prescription is common for respiratory tract infections (RTIs) in primary care, despite evidence to suggest little clinical benefit as many RTIs are viral or self-limiting, with prescribing often attributed uncertainty regarding microbiological diagnosis. Rapid point-of-care tests (POCTRM) have the potential improve diagnostic precision by detecting viruses and bacteria from samples they proposed a way reduce antibiotic antimicrobial resistance. However, there...
Purpose: This study is aimed at exploring the role of pyroptosis‐related genes in development, immune infiltration, and clinical features lung adenocarcinoma. Method: Pyroptosis‐related were searched using online databases, including MSigDB, Gene, GeneCards. We explored gene expression patterns adenocarcinoma UALCAN database. Functional enrichment analysis was performed Metascape A protein–protein interaction network constructed STRING database, outcomes visualized Cytoscape. The top five...
Abstract A wireless system for real‐time bladder volume sensing and timely voiding can manage underactive (UAB) but should avoid imposing long‐term stress on the during application. Here, this work develops a flexible sensing‐actuation that incorporates bistable pre‐shaped polyether ether ketone (PEEK) layer minimizing while maintaining high efficiency by shape memory alloy (SMA) spring actuator. The actuator achieves repeatable of 95–100% within 10 s, after which PEEK is self‐activated 30 s...
Introduction: COVID-19 pandemic remains an acute global emergency. The situation was especially worrying in mainland China. However, paxlovid shortage led to the underuse of recommended antivirus treatment. Hyperbaric oxygen therapy (HBOT) could increase SpO 2 patients with severe hypoxemia. prior trials suggested this potential effectiveness while study design and sample size may not be sufficient illustrating safety HBOT. Therefore, we designed current protocol examine hypothesis that HBO...