A5102858189- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Degradation and Inhibitors
- Nanoplatforms for cancer theranostics
- Hernia repair and management
- Immune Cell Function and Interaction
- Rabbits: Nutrition, Reproduction, Health
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Lipid metabolism and disorders
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Surgical Treatments
- Histone Deacetylase Inhibitors Research
- Hydrogen's biological and therapeutic effects
- Colorectal and Anal Carcinomas
- Organ Transplantation Techniques and Outcomes
- Spinal Cord Injury Research
- Transplantation: Methods and Outcomes
- Ubiquitin and proteasome pathways
- Livestock and Poultry Management
- Nerve injury and regeneration
- Cytomegalovirus and herpesvirus research
- Antimicrobial Peptides and Activities
- Diet, Metabolism, and Disease
Mudanjiang Medical University
2025
Chinese Academy of Sciences
2023-2024
Zhejiang Cancer Hospital
2017-2024
Xinxiang Medical University
2015-2024
Jilin University
2011-2023
Shanghai Sixth People's Hospital
2023
Shanghai Jiao Tong University
2023
Hainan Branch of People's Liberation Army General Hospital
2023
Chinese People's Liberation Army
2023
Qinghai University
2022
The RIG-I like receptors (RLRs) and MDA5 are cytosolic RNA helicases best characterized as restriction factors for viruses. However, evidence suggests RLRs participate in innate immune recognition of other pathogens, including DNA Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus the etiological agent sarcoma primary effusion lymphoma (PEL). Here, we demonstrate that restrict KSHV lytic reactivation facilitated by host-derived RNAs. Misprocessed noncoding RNAs...
The Depression Anxiety Stress Scale-21 (DASS-21) is an instrument in the assessment of mental health status. current study recruited 1,532 Chinese hospital workers [74.4% female; mean age = 31.97 (SD 9.70) years] to examine reliability, latent structure, and measurement invariance DASS-21 between genders. Cronbach's α values were greater than 0.90 for total score. This examined four possible models using confirmatory factor analysis (CFA) workers. results from CFA revealed that structure...
Long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) plays an important role in the pathogenesis and development of several types cancer. However, functional mechanism NEAT1 hepatocellular carcinoma (HCC) remains unclear. microRNA (miR)-129-5p expression HCC tissues cell lines was quantified by means quantitative PCR. The effects inhibition or upregulation were analyzed terms viability apoptosis. Biological software used to predict binding sites miR-129-5p. miR-129-5p target...
Triggering receptor expressed in myeloid cells (TREM)2 is a genetic high-risk factor for sporadic Alzheimer's disease (AD) and considered potential target AD diagnosis therapy, although its role the different stages of remains controversial. We generated an embryonic deletion Trem2 (whole body deletion) induced hippocampa1- cortical-specific knockdown microglial at process amyloid precursor protein/Psen1 mice by adeno-associated virus (AAV) infection. AAV infection overexpression hippocampus...
The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has anti-inflammatory, antioxidant other biological activities, various sea species in pharmaceutical development. However, relevant studies on the effects SCP progression still lacking. In this study, a mouse model acute was induced by 3% dextran sulfate (DSS), effect 500 mg/kg investigated. results showed that can...
ABSTRACT Whether rapamycin has neuroprotective effects in spinal cord injury remains controversial. The present study shows that protects neurons from death after by inhibiting the secondary inflammatory response. of were tested using a myeloperoxidase assay, Western blotting, immunohistochemistry, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. experimental results showed injury, reduced numbers activated microglia neutrophils damage zone, lowered expression...
Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main cause of persistent hyperglycemia type 2 diabetes. Berberine (Zhang et al., 2010) has been used as a hypoglycemic agent, yet mechanism by BBR inhibits gluconeogenesis remains incompletely understood. In this study, we treated diabetic mice with BBR, tested blood levels, and then performed insulin, lactate, tolerance tests. Intracellular cAMP levels hepatocytes were determined ELISA, gluconeogenetic genes...
Florfenicol is a new type of broad-spectrum antibacterial that has been used in veterinary clinics. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) mice. In present study, florfenicol suppressed lipopolysaccharide (LPS)-stimulated splenocyte proliferation concentration-dependent manner vitro and vivo. BALB/c mice were immunized subcutaneously with OVA days 1 4. Following second immunization, treated single daily oral dose (50, 100, 200 mg/kg) for 10 consecutive...
Dianthus superbus is a traditional Chinese medicine that commonly utilized as treatment for inflammation, pain, and immunological conditions. In this study, an anti-inflammatory maltol glycoside derived from was isolated the first time via medium high-pressure liquid chromatography, at same time, in vitro activity of preliminarily explored. Initially, crude samples were preprocessed MCI GEL® CHP20P Spherical C18 medium-pressure under guidance evaluation activity. Fr44 found to be target...
Abstract Sirtuin 6 (Sirt6), a NAD + ‐dependent protein deacetylase, is involved in hepatic glucose metabolism and insulin sensitivity, which impact metabolic homeostasis. In this paper, we discover that Sirt6 affects the sensitivity of mice gender‐dependent manner; few studies have been conducted on issue. Based reports revealing influences sex hormones signaling, investigation explores mechanism by regulates estrogen pathway disrupts signal transduction. Hepatocyte‐specific knockout...
Abstract We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient methionine and choline (MCD). CHR shown to attenuate MCD‐induced hepatic fat accumulation, increase very low‐density lipoprotein (VLDL) secretion, decrease oxidative stress Inhibition or direct suppression protein kinase C (PKC) by significantly reduced PKC activity liver, leading inhibitory phosphorylation hepatocyte nuclear...