A5074641200- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Shoulder Injury and Treatment
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Biliary and Gastrointestinal Fistulas
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced Breast Cancer Therapies
- Anorectal Disease Treatments and Outcomes
- Probiotics and Fermented Foods
- Shoulder and Clavicle Injuries
- Radiomics and Machine Learning in Medical Imaging
Second Affiliated Hospital of Nanjing Medical University
2016-2025
Nanjing Medical University
2016-2025
Jishou University
2025
Shanghai Changzheng Hospital
2025
Westlake University
2025
Hubei University of Medicine
2025
Soochow University
2025
Shenzhen Hanke Bioengineering (China)
2025
National Clinical Research Center for Digestive Diseases
2019-2024
Beijing Union University
2024
Human ingestion of microplastics (MPs) is inevitable due to the ubiquity MPs in various foods and drinking water. Whether poses a substantial risk human health far from understood. Here, by analyzing characteristics feces patients with inflammatory bowel disease (IBD) healthy people, for first time, we found that fecal MP concentration IBD (41.8 items/g dm) was significantly higher than people (28.0 dm). In total, 15 types were detected feces, poly(ethylene terephthalate) (22.3–34.0%)...
The gut microbiota plays a pivotal role in the intestinal diseases. Fecal transplantation (FMT) might be rescue therapy for refractory inflammatory bowel disease. This study aimed to evaluate safety, feasibility, and efficacy of FMT through mid-gut Crohn's disease (CD).We established standardized laboratory protocol clinical work flow FMT. Only CD patients with Harvey-Bradshaw Index (HBI) score ≥ 7 were enrolled this study. All included treated single assessed during follow-up.Metagenomics...
Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To enhance the understanding of gut microbiota structure in ASD children at different ages as well relationship between and fecal metabolites, we first used 16S rRNA sequencing to evaluate microbial population cohort 143 aged 2–13 years old. We found that α-diversity group showed no significant change with age, while TD increased which indicates compositional development varies ways are not consistent group. Recent...
Abstract Fecal microbiota transplantation (FMT) by manual preparation has been applied to treat diseases for thousands of years. However, this method still endures safety risks and challenges the psychological endurance acceptance doctors, patients donors. Population evidence showed washed with microfiltration based on an automatic purification system followed repeated centrifugation plus suspension three times significantly reduced FMT-related adverse events. This washing makes delivering a...
Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota.Recently, it has been considered as treatment Crohn's disease (CD) and certain neurological diseases.Here, to the best our knowledge, we report first case used FMT achieve remission intestinal symptoms in girl with CD 17-year history epilepsy.During 20 mo follow-up, proved its efficacy preventing relapse seizures after withdrawing antiepileptic drugs.Furthermore, this finding...
The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here, we discover that the gut microbiota from DSPN can induce phenotype exhibiting more severe peripheral db/db mice. In randomized, double-blind, and placebo-controlled trial (ChiCTR1800017257), compared to 10 who received placebo, was significantly alleviated 22 fecal transplants healthy donors, independent of glycemic control....
Pyrazole-based inhibitors of the transforming growth factor-beta type I receptor kinase domain (TbetaR-I) are described. Examination SAR in both enzyme- and cell-based vitro assays resulted emergence two subseries featuring differing selectivity versus p38 MAP kinase. A common binding mode at active site has been established by successful cocrystallization X-ray analysis potent with TbetaR-I domain.
Antifolates, folate analogs that inhibit vitamin B 9 (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake antifolates in clinical use occurs primarily via widely expressed facilitative membrane transporters. More recently, human receptors (FRs), high affinity transport endocytosis, proposed as targets specific delivery new classes or conjugates to tumors sites inflammation. The development specific,...
The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed evaluate the efficacy and safety a designed step-up steroid-dependent UC. Fifteen patients with UC were enrolled, treated strategy. Follow-up clinical data was collected minimum 3 months. Fecal composition before post related donors analyzed by 16S rRNA sequencing. Eight fourteen (57.1 %) achieved improvement able...
// Jonathan M. Yingling 1 , William T. McMillen 2 Lei Yan Huocong Huang 3 J. Scott Sawyer Jeremy Graff David K. Clawson Karen S. Britt Bryan D. Anderson Douglas W. Beight Durisala Desaiah Michael Lahn Karim A. Benhadji Maria Lallena Rikke B. Holmgaard Xiaohong Xu Faming Zhang Jason R. Manro Philip Iversen Chandrasekar V. Iyer Rolf Brekken Kalos and Kyla E. Driscoll Idera Pharmaceuticals, Inc., Cambridge, Massachusetts, USA Lilly Research Laboratories, Eli Company, Indianapolis, IN New York,...
The COVID-19 pandemic has led to an exponential increase in SARS-CoV-2 infections and associated deaths, represents a significant challenge healthcare professionals facilities. Individual countries have taken several prevention containment actions control the spread of infection, including measures guarantee safety both patients who are at increased risk infection from COVID-19. Faecal microbiota transplantation (FMT) well-established role treatment Clostridioides difficile infection. In...
As the outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has rapidly spread from China to other countries, governments and medical community are taking steps prevent transmission, common sense recommendations radical quarantine measures.1Xiao Y Torok ME Taking right measures control COVID-19.Lancet Infect Dis. 2020; (published online March 5.)https://doi.org/10.1016/S1473-3099(20)30152-3Summary Full Text PDF PubMed Scopus (220)...
Patients with steroid refractory gastrointestinal (GI) tract graft-versus-host disease (GvHD) have a poor prognosis and limited therapeutic options. To accurately assess the efficacy safety of fecal microbiota transplantation (FMT) in treating GI GvHD, we conducted pilot study involving eight patients. Having received FMTs, all patients' clinical symptoms improved, bacteria enriched, composition reconstructed. They achieved similar overall survival, progression-free survival better than...