A5032718952- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Nosocomial Infections in ICU
- Inflammatory Bowel Disease
- Primary Care and Health Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
- Viral gastroenteritis research and epidemiology
- Diverticular Disease and Complications
- Inflammatory mediators and NSAID effects
- Mycobacterium research and diagnosis
- Dermatological and Skeletal Disorders
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Urinary Tract Infections Management
- Estrogen and related hormone effects
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
Brigham and Women's Hospital
2023-2025
Harvard University
2016-2025
Chestnut Hill College
2024-2025
Brown University
2015-2024
University of Pennsylvania
2024
Lifespan
2015-2023
Miriam Hospital
2015-2023
Perspectives Charter School
2016-2023
Faculty of Media
2019-2022
Advisory Board Company (United States)
2013-2021
Clostridium difficile infection (CDI) has increased to epidemic proportions over the past 15 years, and recurrence rates of 30-65% with failure respond multiple courses antimicrobials are common. The aim this study was report efficacy fecal microbiota transplantation (FMT) in patients recurrent CDI five geographically disparate medical centers across United States. A multicenter long-term follow-up performed on use FMT for CDI. We were able contact 77 94 eligible who had colonoscopic ≥ 3...
Patients who are immunocompromised (IC) at increased risk of Clostridium difficile infection (CDI), which has to epidemic proportions over the past decade. Fecal microbiota transplantation (FMT) appears effective for treatment CDI, although there is concern that IC patients may be having adverse events (AEs) related FMT. This study describes multicenter experience FMT in patients.A retrospective series was performed on use with CDI recurrent, refractory, or severe. We aimed describe rates...
Background: To date, evidence for the efficacy of fecal microbiota transplantation (FMT) in recurrent Clostridium difficile infection (CDI) has been limited to case series and open-label clinical trials. Objective: determine safety FMT treatment CDI. Design: Randomized, controlled, double-blind trial. (ClinicalTrials.gov: NCT01703494) Setting: Two academic medical centers. Patients: 46 patients who had 3 or more recurrences CDI received a full course vancomycin their most recent acute...
Abstract Fecal microbiota transplantation (FMT) is a promising treatment for recurrent Clostridium difficile infection. We report case of woman successfully treated with FMT who developed new-onset obesity after receiving stool from healthy but overweight donor. This may stimulate further studies on the mechanisms nutritional-neural-microbiota axis and reports outcomes in patients have used nonideal donors FMT.
Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of colon. These guidelines indicate preferred approach to management adults with C. represent official practice recommendations American College Gastroenterology. The scientific evidence for these was evaluated using Grading Recommendations Assessment, Development, Evaluation process. In instances where not appropriate but there consensus significant clinical merit, key concept...
Patients with recurrent Clostridium difficile infection (CDI) have a ≥60% risk of relapse, as conventional therapies do not address the underlying gastrointestinal dysbiosis. This exploratory study evaluated safety and efficacy bacterial spores for preventing CDI.Stool specimens from healthy donors were treated ethanol to eliminate pathogens. The resulting fractionated encapsulated oral delivery SER-109. Following their response standard-of-care antibiotics, patients in cohort 1 SER-109 on 2...
Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, lower response to conventional treatment than general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but not been studied specifically elderly. This study aims determine long-term efficacy safety of FMT recurrent (RCDI), severe (SCDI), complicated (CCDI) patients.A multicenter, follow-up was performed with demographic, pre-FMT, post-FMT data...
New treatments are needed as Clostridium difficile infection (CDI) is becoming increasingly formidable. Fecal microbiota transplantation (FMT) has a 90% success rate in the treatment of recurrent CDI. However, evidence regarding its safety, efficacy, and effect on disease activity patients with inflammatory bowel (IBD) lacking. This cohort study used data from 8 national international academic centers. Patients established IBD who underwent FMT for CDI were followed minimum 3 months. The...
Fecal microbiota-based therapies include conventional fecal microbiota transplant and US Food Drug Administration-approved therapies, live-jslm spores live-brpk. The American Gastroenterological Association (AGA) developed this guideline to provide recommendations on the use of in adults with recurrent Clostridioides difficile infection; severe fulminant C inflammatory bowel diseases, including pouchitis; irritable syndrome.
Importance A safe and effective treatment for recurrent Clostridioides difficile infection (CDI) is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted microbiome, which promotes spore germination recurrence. Objectives To evaluate safety rate of CDI recurrence after administration investigational microbiome therapeutic SER-109 through 24 weeks. Design, Setting, Participants This phase 3, single-arm, open-label trial (ECOSPOR IV) was conducted at 72 US...
Goals: We aim to present a data detailing our success with fecal microbiota transplantation (FMT) and provide simple treatment protocol. Background: Relapse is common problem in patients treated for Clostridium difficile infection, often requiring prolonged courses of oral vancomycin limited alternative options. Administration the entire flora from healthy individual restore beneficial physiological species referred as FMT (also termed bacteriotherapy or stool transplant). Although...
Prosthetic aortic graft infections represent a major diagnostic and therapeutic challenge. Although combination of clinical assessment, imaging microbiological investigations is usually helpful, there are no agreed criteria to confirm diagnosis. Potential pathogens isolated from superficial specimens may be misleading but influence the choice antimicrobial agents. Removal infected material strongly recommended. However, this not always possible in very debilitated or clinically unstable...
The COVID-19 pandemic has led to an exponential increase in SARS-CoV-2 infections and associated deaths, represents a significant challenge healthcare professionals facilities. Individual countries have taken several prevention containment actions control the spread of infection, including measures guarantee safety both patients who are at increased risk infection from COVID-19. Faecal microbiota transplantation (FMT) well-established role treatment Clostridioides difficile infection. In...
As the outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has rapidly spread from China to other countries, governments and medical community are taking steps prevent transmission, common sense recommendations radical quarantine measures.1Xiao Y Torok ME Taking right measures control COVID-19.Lancet Infect Dis. 2020; (published online March 5.)https://doi.org/10.1016/S1473-3099(20)30152-3Summary Full Text PDF PubMed Scopus (220)...
Fecal microbiota transplant (FMT) is a highly efficacious treatment for recurrent or refractory Clostridium difficile infection (CDI); however, 10-20% of patients fail to achieve cure after single FMT. The aim this study was identify risk factors associated with FMT failure and develop validate prediction model failure.Patient characteristics, CDI history, outcomes data treated between 2011 2015 at three academic tertiary referral centers were prospectively collected. Early defined as...