A5071045232- Inflammatory Bowel Disease
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
- Gallbladder and Bile Duct Disorders
- Advances in Oncology and Radiotherapy
- Innovations in Medical Education
- Immunodeficiency and Autoimmune Disorders
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Potassium and Related Disorders
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Screening and Detection
- Autoimmune Bullous Skin Diseases
Emory University
2014-2023
Centre For Digestive Diseases
2020
Office of Infectious Diseases
2018
Children's Healthcare of Atlanta
2013
Patients with recurrent Clostridium difficile infection (CDI) have a ≥60% risk of relapse, as conventional therapies do not address the underlying gastrointestinal dysbiosis. This exploratory study evaluated safety and efficacy bacterial spores for preventing CDI.Stool specimens from healthy donors were treated ethanol to eliminate pathogens. The resulting fractionated encapsulated oral delivery SER-109. Following their response standard-of-care antibiotics, patients in cohort 1 SER-109 on 2...
Interindividual variation in response to anti-TNFalpha therapy may be explained by genetic variability disease pathogenesis or mechanism of action. Recent genome-wide association studies (GWAS) inflammatory bowel (IBD) have increased our understanding the susceptibility IBD. The aim was test associations known IBD loci and novel "pharmacogenetic" GWAS identified with primary nonresponse pediatric patients develop a predictive model nonresponse.Primary defined using Harvey Bradshaw Index...
Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors failure SOT patients. Primary cure overall were defined as resolution of diarrhea or negative C stool test after a single subsequent FMT(s) ± anti-CDI antibiotics, respectively. Ninety-four underwent FMT, 78%...
Mesenchymal stromal cells ability to reset immune functionalities may be useful in Crohn's disease.To perform a first-in-human phase 1 safety clinical trial of metabolically fit autologous bone marrow-derived mesenchymal 12 subjects with disease utilising three doses.Autologous were derived from marrow aspirate and propagated for 2-3 weeks fibrinogen depleted human platelet lysate subsequently administered without interval cryobanking. Twelve received single cell intravenous infusion 2, 5 or...
Whether or not populations diverge with respect to the genetic contribution risk of specific complex diseases is relevant understanding evolution susceptibility and origins health disparities. Here, we describe a large-scale whole-genome sequencing study inflammatory bowel disease encompassing 1,774 affected individuals 1,644 healthy control Americans African ancestry (African Americans). Although no new loci for are discovered at genome-wide significance levels, identify numerous instances...
Fecal microbiota transplant (FMT) appears safe and effective for treatment of recurrent Clostridium difficile infection (RCDI). However, durability, long-term clinical outcomes, patient satisfaction after FMT are not well described. Eligible patients who received RCDI at Emory Hospital between 1 July 2012 31 December 2016 were contacted via telephone a follow-up survey. Of 190 eligible patients, 137 (72%) completed the Median time from last to was 22 months. Overall, 82% (113/137) had no...
Fecal microbiota transplant has become more acceptable as a therapeutic for recurrent Clostridium difficile infection. The FDA an enforcement discretion policy practitioner's performing this therapy, which includes informed consent experimental treatment. This manuscript describes typical procedure that can be followed the important aspects of preparation and
Vitamin D deficiency and low bone mineral density (BMD) are complications of inflammatory bowel disease. is more prevalent among African Americans compared with whites. There little data comparing differences in serum 25-hydroxyvitamin (25OHD) concentrations BMD between American white children Crohn disease (CD).
BACKGROUND: Clostridium difficile infection has been associated with negative outcomes in the general population and pregnant patients. Fecal microbiota transplant become standard for treatment of recurrent as well refractory C infection. CASE: We present a case 28-year-old woman who presented despite vancomycin fidaxomicin underwent successful fecal through colonoscopy at 18 weeks gestation. She no longer required antibiotics remainder her pregnancy to treat had term vaginal delivery 39...
Crohn's disease (CD) is highly heritable. NOD2 has emerged as the main susceptibility gene among individuals of European ancestry; however, does not appear to contribute CD many non-European populations. Today's African American (AA) population represents an admixture West (80%) and (20%) ancestry. Since genotype-based tools are becoming increasingly available for CD, it important that we validate risk variants in different populations, such admixed AAs. We analyzed AAs (n = 321, 240 with...
The objective of this study was to describe the safety fecal microbiota transplant (FMT) for Clostridium difficile infection (CDI) among older adults.We performed a case review all FMT recipients aged 65 or treated at Emory University Hospital, tertiary care and referral center Georgia surrounding states.CDI resolved in 27 (87%) 31 respondents, including three individuals who received multiple FMTs. Among four whose CDI not follow up, respondents did well initially before recurred, one...