A5071200615- Diabetes and associated disorders
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Ophthalmology and Eye Disorders
- Adipose Tissue and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Tea Polyphenols and Effects
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Birth, Development, and Health
- T-cell and B-cell Immunology
- Metabolism, Diabetes, and Cancer
- Food composition and properties
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Kidney Stones and Urolithiasis Treatments
Zunyi Medical University
2019-2025
First Hospital of Shanxi Medical University
2017-2024
Shanxi Medical University
2017-2024
Tianjin Medical University
2014-2024
Ministry of Agriculture and Rural Affairs
2024
Tianjin Medical University General Hospital
2014-2024
Anhui Agricultural University
2024
Tianjin University of Technology
2024
Peking University
2005-2024
Peking University Third Hospital
2024
The gut microbiota plays a pivotal role in the intestinal diseases. Fecal transplantation (FMT) might be rescue therapy for refractory inflammatory bowel disease. This study aimed to evaluate safety, feasibility, and efficacy of FMT through mid-gut Crohn's disease (CD).We established standardized laboratory protocol clinical work flow FMT. Only CD patients with Harvey-Bradshaw Index (HBI) score ≥ 7 were enrolled this study. All included treated single assessed during follow-up.Metagenomics...
Stem cell transplantation showed promising results in IBD management. However, the therapeutic impacts of delivery route that is critical for clinical translation are currently poorly understood. Here, three different MSCs routes: intraperitoneal (IP), intravenous (IV), and anal injection (AI) were compared on DSS-induced colitic mice model. The overall factors, migration targeting as well local immunomodulatory cytokines FoxP3(+) cells infiltration analyzed. Colitis varying degrees...
Bispecific antibodies (BsAbs) represent an emerging class of biologics that achieve dual targeting with a single agent. Recombinant DNA technologies have facilitated variety creative bispecific designs many promising therapeutic applications; however, practical methods for producing high quality BsAbs good product stability, long serum half-life, straightforward purification, and scalable production largely been limiting. Here we describe protein-engineering approach stable, tetravalent...
This study aimed to determine the optimal cutoff values and evaluate associations of neutrophil high-density lipoprotein cholesterol ratio (NHR) lymphocyte (LHR) with metabolic syndrome (MetS), stratified by sex.A large-scale cross-sectional survey was conducted among 1401 adults from January April 2018 in six communities Wanzhai Town, Zhuhai City, on southern coast China. Receiver operating characteristics (ROC) analyses logistic regression analysis were assess value NHR LHR for predicting...
Tea stems are a type of tea by-product, and considerable amount them is discarded during picking, with their value often being overlooked. To enhance the utilization stems, we investigated effects different expansion temperatures on non-volatile compounds stems. The results showed that contents EC, EGC, EGCG, polyphenols, amino acids all decreased temperature, while GA C increased. best effect was observed at 220 °C for 20 s. Additionally, as temperature increased, umami aftertaste...
Thyroid-associated ophthalmopathy (TAO) is one of the most common orbital diseases that seriously threatens visual function and significantly affects patients' appearances, rendering them unable to work. This study established an intelligent diagnostic system for TAO based on facial images.Patient images data were obtained from medical records patients with who visited Shanghai Changzheng Hospital 2013 2018. Eyelid retraction, ocular dyskinesia, conjunctival congestion, other signs noted...
Colorectal cancer (CRC) is related to gut microbiota dysbiosis, especially butyrate-producing bacteria reduction. Our previous study suggested that administration of Clostridium butyricum, a bacterium, exerts crucial effect against CRC, however the potential mechanism not clear. We first found methyltransferase-like 3 (METTL3) showed positive correlation with proliferation, epithelial-mesenchymal transition (EMT), DNA repair, metastasis, and invasion in database analysis. The expression...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to the accumulation of lipid droplets (LD), central hubs metabolism, in vitro or type II pneumocytes and monocytes from coronavirus disease 19 (COVID-19) patients blockage LD formation by specific inhibitors impedes SARS-CoV-2 replication. Here, we showed that ORF3a is necessary sufficient trigger during infection, leading efficient virus Although highly mutated evolution, ORF3a-mediated modulation conserved most...
Fecal microbiota transplantation (FMT) has been recommended for the treatment of recurrent Clostridioides difficile infection (CDI). We aimed to evaluate therapeutic efficacy and safety washed (WMT), a new method FMT, CDI across various medical settings.This multicenter real-world cohort study included patients undergoing WMT. The primary outcome was clinical cure rate within 8 weeks after Secondary outcomes recurrence reduction in total abdominal symptom score (TASS) during follow-up...
Doxycycline (Dox) is a tetracycline derivative with broad-spectrum antimicrobial activities that used as an effector substance in inducible gene-expression systems. We investigated the antiviral activity of Dox against vesicular stomatitis virus (VSV) infection cultured H1299 cells. at concentrations 1.0–2.0 μg ml−1 significantly inhibited VSV replication and VSV-induced cytopathic effect dose-dependent manners, suggesting may have broader inhibiting viral replication, addition to its...
Introduction: Cataract may cause severe visual impairment in eyes with microphthalmos and uveal coloboma. Despite their similarities, distinguishing between these conditions is crucial for cataract surgery. We aimed to compare complications, nucleus hardness, surgical strategies, outcomes of surgery Methods: This retrospective comparative study included 19 20 Preoperative, intraoperative, postoperative data that underwent were analysed. Results: MO had lower high-hardness rates (P=0.002)...