A5101736932- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Plant-based Medicinal Research
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Phytochemical compounds biological activities
- Natural Antidiabetic Agents Studies
- Microbial Metabolism and Applications
- Phytochemicals and Antioxidant Activities
- Polysaccharides and Plant Cell Walls
- Medicinal Plant Research
- Medicinal Plants and Bioactive Compounds
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Phytoestrogen effects and research
China Pharmaceutical University
2018-2025
Inner Mongolia Medical University
2025
Xuzhou Medical College
2015-2024
Taiyuan Heavy Industry (China)
2023-2024
Nanjing University of Chinese Medicine
2012-2023
University of Science and Technology Beijing
2023
Henan University of Technology
2023
Jiangsu University
2011-2020
Nanjing Library
2020
Jiangsu Provincial Academy of Traditional Chinese Medicine
2009-2018
An effective anti-cancer drug, icariside II (IS), has been used to treat a variety of cancers in vitro. However, its poor aqueous solubility and permeability lead low oral bioavailability. The aim this work was use Solutol®HS15 Pluronic F127 as surfactants develop novel mixed micelles enhance the bioavailability IS by improving inhibiting efflux. IS-loaded were prepared using method ethanol thin-film hydration. physicochemical properties, dissolution property, male SD rats, efflux Caco-2...
Enhancing the dissolution, permeation and absorption of active components with low solubility poor permeability is crucial for maximizing therapeutic efficacy optimizing functionality. The objective this study to investigate potential natural polysaccharides as carriers improve biopharmaceutical properties components.In study, we employed four representative flavonoids in Astragali Radix, namely Calycosin-7-O-β-D-glucoside (CAG), Ononin (ON), Calycosin (CA) Formononetin (FMN), a...
The purpose of this study was to continue our effort determine how enzyme-transporter coupling affect disposition flavonoids. rat intestinal perfusion and Caco-2 cell models were used together with relevant microsomes. In model, isoflavone (i.e., formononetin biochanin A) absorption subsequent excretion its metabolites always site-dependent. Maximal amounts biliary conjugates excreted per 30 min 31 51 nmol for formononetin, more than that pure A (12 20 nmol). When a standardized red clover...
The main purpose of this study was to evaluate the intestinal absorption and antineoplastic effect poorly water-soluble drug celastrol when liposomes were used as oral delivery system. Liposomes prepared by ethanol-injection method. An optimized liposome formulation composed phospholipid, cholesterol Tween-80 resulted in favorable encapsulation efficiency at 98.06 ± 0.94%. Homogeneous stable particle size 89.6 7.3 nm zeta potential −(87.7 5.8) mV determined laser analyzer. Subsequently,...
In the present paper, effect of β-cyclodextrin (β-CD) inclusion complexation on solubility and enzymatic hydrolysis naringin was investigated. The complex naringin/β-CD at molar ratio 1:1 obtained by dropping method characterized differential scanning calorimetry. complexes in water 37 ± 0.1 °C 15 times greater than that free naringin. Snailase-involved conditions were tested for bioconversion into naringenin using univariate experimental design. Naringin can be transformed snailase-involved...