A5081825319- Metabolomics and Mass Spectrometry Studies
- Ion channel regulation and function
- Aquaculture Nutrition and Growth
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Meat and Animal Product Quality
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- Identification and Quantification in Food
- Cardiac electrophysiology and arrhythmias
- Seismic Waves and Analysis
- Nitric Oxide and Endothelin Effects
- Mass Spectrometry Techniques and Applications
- Fungal and yeast genetics research
- Advanced Chemical Sensor Technologies
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- RNA Research and Splicing
- Telomeres, Telomerase, and Senescence
- Fatty Acid Research and Health
- Insect Resistance and Genetics
- Cardiomyopathy and Myosin Studies
- Earthquake Detection and Analysis
- Biochemical and Structural Characterization
The University of Texas Southwestern Medical Center
2020-2025
Howard Hughes Medical Institute
2020-2025
Zhejiang Gongshang University
2016-2024
Children's Medical Research Institute
2009-2024
The University of Sydney
2012-2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Center for Life Sciences
2023
Tsinghua University
2023
Tianjin University of Traditional Chinese Medicine
2023
Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due ability sensitize cancerous cells chemotherapy, radiation therapy, and induce apoptosis. present study investigated the interaction zinc ions with a human ovarian cancer cell line (A2780). enhanced uptake by A2780 concentration-dependent manner, as assayed using fluorescent probe. This enhancement was attenuated...
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T through an 'inside out' signalling process whereby structurally diverse phosphoantigen (pAg) molecules sensed by the intracellular domain of butyrophilin BTN3A11-4. Here we show how-in humans alpaca-multiple pAgs function as 'molecular glues' promote heteromeric association between domains BTN3A1 similar BTN2A1. X-ray crystallography studies visualized that engagement with forms a composite interface for direct...
Abstract Chrysin is a natural flavonoid and has been shown recently to have anticancer effects. However, the mechanisms that chrysin inhibits cancers are not well known. In this study, we investigated effects of on expression hypoxia-inducible factor-1α (HIF-1α) vascular endothelial growth factor in human prostate cancer DU145 cells. inhibited insulin-induced HIF-1α by reducing its stability. increases ubiquitination degradation increasing prolyl hydroxylation. addition, interfered with...
Diabetes-induced hyperglycemia increases the extracellular concentration of methylglyoxal. Methylglyoxal-derived hydroimidazolones (MG-H) form advanced glycation end products (AGEs) that accumulate in serum diabetic patients. The binding hydroimidozolones to receptor for AGEs (RAGE) results long-term complications diabetes typified by vascular and neuronal injury. Here we show methylglyoxal-modified albumin RAGE signal transduction. Chemically synthesized peptides containing bind...
Abstract Emerging as a cost‐effective and robust enzyme mimic, nanozymes have drawn increasing attention with broad applications ranging from cancer therapy to biosensing. Developing both accelerated inhibited biocatalytic properties in biological context is intriguing peruse more advanced functions of natural enzymes, but remains challenging, because most are lack enzyme‐like molecular structures. By re‐visiting engineering the well‐known Fe‐N‐C electrocatalyst that has heme‐like Fe‐N x...
In this study, the gel properties of myofibrillar proteins (MPs) from four meat sources (fish, beef, sheep, and pork) were compared. Oscillatory rheology measurements including temperature sweep, frequency strain sweep conducted to characterise small large deformation rheological MPs. addition, sodium dodecyl sulfate polyacrylamide electrophoresis (SDS-PAGE) scanning electron microscopy (SEM) used evaluate differences in molecular weight distribution as well microstructures among different...
Transient receptor potential mucolipin 1 (TRPML1) is a Ca2+-permeable, nonselective cation channel ubiquitously expressed in the endolysosomes of mammalian cells and its loss-of-function mutations are direct cause type IV mucolipidosis (MLIV), an autosomal recessive lysosomal storage disease. TRPML1 ligand-gated that can be activated by phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] as well some synthetic small-molecule agonists. Recently, rapamycin has also been shown to directly bind...
Historically introduced by McConkey to explain the slow mutation rate of highly abundant proteins, weak protein (quinary) interactions are an emergent property living cells. The complexes that result from quinary transient and thus difficult study biochemically in vitro. Cross-correlated relaxation-induced polarization transfer-based in-cell nuclear magnetic resonance allows characterization with atomic resolution inside live prokaryotic eukaryotic We show RNAs important component...
ZnT8 is a Zn
A 3D biomass-derived photothermal platform is constructed with gradient microchannels, exhibiting capabilities for accelerating water evaporation, microplastic degradation, and all-day-round evaporation.
Abstract Na + /Ca 2+ exchangers (NCX) transport Ca in or out of cells exchange for . They are ubiquitously expressed and play an essential role maintaining cytosolic homeostasis. Although extensively studied, little is known about the global structural arrangement eukaryotic NCXs mechanisms underlying their regulation by various cellular cues including Here we present cryo-EM structures human cardiac NCX1 both inactivated activated states, elucidating key elements important NCX ion function...
Temperature fluctuations occurring during the cold chain logistics of salmon contribute to lipid oxidation. This study aimed simulate interruption through freeze–thaw operations and evaluate lipidomics data from samples subjected different numbers cycles by using rapid evaporative ionization mass spectrometry (REIMS) combined with an intelligent surgical knife (iKnife). The results indicated significant differences in relative abundance characteristic ions among (p < 0.05). A total 34...
Abstract The septins are GTPase enzymes with multiple roles in cytokinesis, cell polarity or exocytosis. proteins from the mammalian septin genes called Sept1–10. Most expressed tissues, but mRNA for Sept5 (CDCrel‐1) and Sept3 (G‐septin) appear to be primarily brain. is phosphorylated by cGMP‐dependent protein kinase I (PKG‐I) cGMP/PKG pathway involved presynaptic plasticity. Therefore determine whether specifically associates neurones nerve terminals we investigated its distribution rat...
A novel cry1A was cloned from Bacillus thuringiensis strain BT8 and expressed in the B. acrystalliferous mutant HD73−. The gene, designated cry1Ah1, encoded a protein with molecular weight of 134 kDa. Reverse transcriptase-PCR Western blotting showed that Cry1Ah host BT8. toxin HD73− exhibited high toxicity against lepidopteran larvae Ostrinia furnacalis, Helicoverpa armigera, Chilo suppressalis, Plutella xylostella. 50% lethal concentrations (LC50s) were 0.05, 1.48, 0.98 μg g−1 1.52 mL−1,...