A5075963891- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Luminescence and Fluorescent Materials
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photodynamic Therapy Research Studies
- Nanocluster Synthesis and Applications
- bioluminescence and chemiluminescence research
- Advanced Biosensing Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Chemical Synthesis and Analysis
- HER2/EGFR in Cancer Research
- Biochemical and Structural Characterization
- Luminescence Properties of Advanced Materials
Stanford University
2015-2025
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2019-2025
Imaging Center
2025
University of Chinese Academy of Sciences
2022-2025
Beijing Tongren Hospital
2024-2025
Capital Medical University
2024-2025
Changzhi Medical College
2024-2025
Southern University of Science and Technology
2022-2025
Eastern Institute of Technology, Ningbo
2024-2025
Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images a subject the use Raman spectroscopy. We describe strategy optical based on spectroscopy nanoparticles. Surface-enhanced scattering nanoparticles single-wall carbon nanotubes were demonstrate whole-body imaging, nanoparticle pharmacokinetics, multiplexing,...
Abstract Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree clarity. NIR-II fluorophores draw from a broad spectrum materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble molecules >1,000 nm emission suffer low quantum yields that have limited temporal resolution and penetration depth. Here, we report tailoring supramolecular assemblies...
Trading up: A bioimaging system that is based on caged D-luciferin/upconversion nanoparticle conjugate has been developed. The nanoparticles upconvert near-infrared light into UV light, which triggers the photorelease of D-luciferin (see scheme) and leads to enhanced fluorescence bioluminescence signals in vitro vivo. use enables deep penetration tissue vivo with minimum cellular damage. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
The effect of nanoparticle size (30−120 nm) on magnetic resonance imaging (MRI) hepatic lesions in vivo has been systematically examined using polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles (PVP-IOs). Such biocompatible PVP-IOs with different sizes were synthesized by a simple one-pot pyrolysis method. These exhibited good crystallinity and high T2 relaxivities, the relaxivity increased nanoparticles. It was found that cellular uptake changed both surface physiochemical...
This study evaluates the influence of particle size, PEGylation, and surface coating on quantitative biodistribution near-infrared-emitting quantum dots (QDs) in mice. Polymer- or peptide-coated 64Cu-labeled QDs 2 12 nm diameter, with without polyethylene glycol (PEG) molecular weight 2000, are studied by serial micropositron emission tomography imaging region-of-interest analysis, as well transmission electron microscopy inductively coupled plasma mass spectrometry. PEGylation peptide slow...
Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless biocompatible integration with human body. A remaining challenge is to combine high mechanical robustness good electrical conduction, especially when patterned at small feature sizes. We develop a molecular engineering strategy topological supramolecular network, which allows decoupling of competing effects from multiple building blocks meet...
Developing multifunctional and easily prepared nanoplatforms with integrated different modalities is highly challenging for molecular imaging. Here, we report the successful transfer of an important target, melanin, into a novel multimodality imaging nanoplatform. Melanin abundantly expressed in melanotic melanomas thus has been actively studied as target melanoma In our work, biopolymer nanoplatform based on ultrasmall (<10 nm) water-soluble melanin nanoparticle (MNP) was developed showed...
Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, second near-infrared window (NIR-II, 1000-1700 nm) is at the forefront on optical techniques. Small-molecule based NIR-II (1000-1700 dyes are promising candidates for in vivo molecular because their high biocompatibility, fast excretion, clinical translation ability. However, reports small-molecule probes rare. Herein, we designed series fluorescent compounds (Q1, Q2, Q3, Q4) investigated...
This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores for<italic>in vivo</italic>tumor imaging and image-guided sentinel lymph node surgery.
In order to promote preclinical and clinical applications of photoacoustic imaging, novel contrast agents are highly desired for molecular imaging diseases, especially deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles reported as an efficient agent brain tumors in living mice with enhanced permeability retention effect.
In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, this biopolymer good biocompatibility biodegradability, binding ability drugs ions, intrinsic photoacoustic properties, can serve as an efficient nanosystem tumor in living mice. As a service our authors readers, journal provides supporting information supplied by...
Compared with imaging in the visible (400–650 nm) and near‐infrared window I (NIR‐I, 650–900 regions, II (NIR‐II, 1000–1700 is a highly promising vivo modality improved resolution deeper tissue penetration. Here, small molecule NIR‐II dye,5,5′‐(1H,5H‐benzo[1,2‐c:4,5‐c′] bis[1,2,5]thiadiazole)‐4,8‐diyl)bis( N , ‐bis(4‐(3‐((tert‐butyldimethylsilyl)oxy)propyl)phenyl) thiophen‐2‐amine), successfully encapsulated into phospholipid vesicles to prepare probe CQS1000. The novel studied for...
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000–1700 nm) window has gained increasing interest clinical application. Till now, very few studies have been exploited small-molecule fluorophores with both excitation and emission NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes absorption developed for imaging, providing feasibility to directly compare optical NIR-IIa (1300–1400 subwindow under 1064 nm that 808 excitation. The...
PDFT1032, a new semiconducting polymer possessing favorable absorption peak (1032 nm) and outstanding biocompatibility, may be widely applicable in clinical imaging the surgical treatment of malignancy.
As a newly noninvasive emerging modality, NIR-II fluorescence imaging (1000-1700 nm) has many advantages over conventional visible and NIR-I (700-900 nm). Unfortunately, only few fluorophores are suitable for bone imaging. Here, we report an fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG), which shows inherent affinity to without linking any targeting ligands, thus, it provides alternative nonradiation strategy skeletal system mapping disease...