A5100366215- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- Cardiac Fibrosis and Remodeling
- Dendrimers and Hyperbranched Polymers
- Advanced Nanomaterials in Catalysis
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Advanced Polymer Synthesis and Characterization
- Porphyrin and Phthalocyanine Chemistry
- Bacterial Genetics and Biotechnology
- Photopolymerization techniques and applications
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Microfluidic and Capillary Electrophoresis Applications
- CAR-T cell therapy research
- Supramolecular Self-Assembly in Materials
- Protein Degradation and Inhibitors
- Advanced Biosensing Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Signaling Pathways in Disease
- Anaerobic Digestion and Biogas Production
Wuhan Institute of Technology
2013-2025
Xiangya Hospital Central South University
2019-2025
Central South University
2019-2025
Stanford University
2019-2025
Wuhan University
2013-2024
Renmin Hospital of Wuhan University
2024
Yangtze Optical Electronic (China)
2024
Heilongjiang Provincial Academy of Agricultural Sciences
2023
Peking University
2022
Xidian University
2022
As a newly noninvasive emerging modality, NIR-II fluorescence imaging (1000-1700 nm) has many advantages over conventional visible and NIR-I (700-900 nm). Unfortunately, only few fluorophores are suitable for bone imaging. Here, we report an fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG), which shows inherent affinity to without linking any targeting ligands, thus, it provides alternative nonradiation strategy skeletal system mapping disease...
Robust but ultrasensitive biosensors with a capability of detecting low abundance biomarkers could revolutionize clinical diagnostics and enable early detection cancer, neurological diseases, infections. We utilized combination localized surface plasmon resonance (LSPR) refractive index sensing the well-known enzyme-linked immunosorbent assay to develop simple colorimetric biosensing methodology single molecule sensitivity. The technique is based on spectral imaging large number isolated...
Abstract Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes the second near‐infrared window (NIR‐II, 1000–1700 nm) show high promise because their exceptional detection sensitivity, resolution, deep imaging depth. Here, a sharp pH‐sensitive self‐assembling cyclopeptide‐dye, SIMM1000, as smart nanoprobe NIR‐II diseases living animals, is reported. This small molecule assembled exhibits...
Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct accurate local can be performed in a noninvasive manner by PTT. This strategy requires use photothermal agents convert light energy into heat energy, thereby achieving heating triggering biochemical processes kill tumor cells. As key factor PTT, conversion ability directly determines efficacy In addition, generally have imaging (PTI) photoacoustic (PAI)...
A stimuli-sensitive chitin derivative with water solubility was used for electrochemically stimulated protein release. Chitin homogeneously functionalized acrylamide (AM) through Michael addition in NaOH/urea aqueous solution. The product characterized by Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), 1H nuclear magnetic resonance (1H-NMR), gel permeation chromatography (GPC) and titration methods. results show that the relates to two functional groups (i.e. acylamino...
Graphene oxide (GO)‐based theranostic nanohybrid is designed for tumor induced imaging and potential combinational therapy. The anti‐tumor drug, Doxorubicin (DOX) chemically conjugated to the poly(ethylenimine)‐co‐poly(ethylene glycol) (PEI‐PEG) grafted GO via a MMP2‐cleavable PLGLAG peptide linkage. therapeutic efficacy of DOX locked its intrinsic fluorescence quenched by under normal physiological condition. Once stimulated MMP2 enzyme over‐expressed in tissues, resulting cleavage permits...
Significance New technologies have fostered renewed interest in bacterial epigenetics, with DNA modifications defending against other microbes and controlling gene expression. Here, we describe how two diverse modifications, adenine methylation ( 6m A) phosphorothioation (PT), evolved to occupy the same genomic sites bacteria. Using mass spectrometry, single-molecule real-time sequencing, genetic engineering, discovered coincident PT A G PS AAC ATC, representing consensus sequences, a...
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling contribute poor prognosis rehabilitation AMI patients. We revealed effects HSP47 on myocardial ischemia-reperfusion (IRI) shed light underlying molecular mechanism. generated adult mice with lentivirus-mediated or miRNA (mi1/133TS)-aided fibroblast-selective overexpression. Myocardial IRI was induced by 45-min...
Mitochondria-targeting photothermal therapy could significantly enhance the tumor cell killing effect. However, since therapeutic reagents need to overcome a series of physiological obstacles arrive at mitochondria accurately, precise mitochondria-targeting still faces great challenges. In this study, we developed self-delivery nanoplatform that specifically targeted cells for therapy. Photothermal agent IR780 was encapsulated by amphiphilic apoptotic peptide KLA with ability form...
Abstract Nanoparticulate drug‐delivery systems have attained much importance because of their injectable property, the possibility to achieve passive targeting and active targeting, unique advantages realize stimuli tailored delivery. Molecular self‐assembly is a powerful method for fabricating polymer‐based nanoparticles, which involves various driving forces, such as hydrophobic interactions, electrostatic stereocomplexation, host/guest interactions hydrogen bonding. By fine tuning one or...
By using a CaCO3 co-precipitation technique, p53 expression plasmids and doxorubicin hydrochloride (DOX) were encapsulated in nano-sized CaCO3/DNA/DOX co-precipitates for co-delivery of genes drugs. Under certain Ca2+/CO32− ratio the co-precipitation, both plasmid DNA drugs could be loaded nanoparticles with high encapsulation efficiency. The vitrocell inhibition was evaluated HeLa cells by MTT assay. results showed simultaneous treatment gene drug induce cell apoptosis completely inhibit...
Open source software has been widely used in various industries due to its openness and flexibility, but it also brings potential security problems. Together with the large-scale increase number of complexity, traditional manual methods deal these issues are inefficient cannot meet current cyberspace requirements. Therefore, is an important research topic for researchers field develop more intelligent technologies apply software. The development deep learning technology brought new...
The mechanism of how SARS-CoV-2 causes severe multi-organ failure is largely unknown. Acute kidney injury (AKI) one the frequent organ damage in COVID-19 patients. Previous studies have shown that human renal tubule cells could be potential host targeted by SARS-CoV-2. Traditional cancer cell lines or immortalized are genetically and phenotypically different from cells. Animal models widely used, but often fail to reflect a physiological pathogenic status because species tropisms. There an...
Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing need for accurate in vivo diagnostic tools that can afford valuable pathophysiological insight into functioning of neurovascular unit space time. Currently, understanding perfusion BBB evolution under both physiological pathological conditions remains sparse, largely owing limitations methods recording diminutive route cerebral blood flow. Here, it is...
Tumor immune checkpoint therapy (ICT) aims to block escape signals between tumor and cells. However, low delivery efficiency of inhibitors (ICIs), narrow single-target approach, reduced responsiveness notably hinder clinical development ICT. Here, we developed a nanoliposome-bacteria hybrid system that acts as an antibody (Ab) factory, enabling precise targeting macrophage activation in hypoxic environments. We reprogrammed attenuated Escherichia coli MG1655 synthesize CD47 antibodies...
Nanocarriers have been extensively utilized to improve the stability of photothermal agents in vivo, enhance delivery efficiency, and reduce drug side effects. However, challenges, such as low safety carrier materials, insufficient loading therapeutic agents, complex preparation procedures, still persist. In this study, agent IR780 was encapsulated network TA-Fe3+ (TF) which self-assembled by tannic acid (TA) Fe3+ synthesize an acid-responsive multifunctional nanophotothermal TF@IR780 (TR)....
By exploiting boronic acid coupling and host–guest chemistry, a pH‐responsive drug/gene co‐delivery nanoplatform is designed for cancer treatments with the excellently serum‐tolerant transfection activity capability to load release hydrophobic drugs in an acidity‐accelerated manner. Via boronate linkage, γ ‐CD allowed spontaneously attach onto phenylboronic‐acid‐modified oligoethylenimine (PEI1.8K‐PB 2.9 ) at neutral condition. The formed vehicle/DNA nanoformulation thus surrounded densely...