A5100355304- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- MRI in cancer diagnosis
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Helicobacter pylori-related gastroenterology studies
Wuhan National Laboratory for Optoelectronics
2024-2025
Huazhong University of Science and Technology
2018-2025
Zhuhai People's Hospital
2021-2025
Jinan University
2019-2025
Affiliated Hospital of North Sichuan Medical College
2022-2024
Shanghai University of Traditional Chinese Medicine
2011-2024
Tsinghua University
2020-2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Nanchang University
2016-2023
Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by cells resist under specific mechanisms. Inhibiting copper transporter ATPase (ATP7A) was found to disrupt ion homeostasis, thereby enhancing the effect cuproptosis and eventually inhibiting invasion metastasis. In this study, we develop a multifunctional nanoplatfrom based on Cu9S8 (CAPSH), designed enhance in specifically targeting ATP7A interference, while combining thermodynamic...
Tumor immune checkpoint therapy (ICT) aims to block escape signals between tumor and cells. However, low delivery efficiency of inhibitors (ICIs), narrow single-target approach, reduced responsiveness notably hinder clinical development ICT. Here, we developed a nanoliposome-bacteria hybrid system that acts as an antibody (Ab) factory, enabling precise targeting macrophage activation in hypoxic environments. We reprogrammed attenuated Escherichia coli MG1655 synthesize CD47 antibodies...
Increasing evidence has suggested an important role played by reactive oxygen species in the pathogenesis of osteoporosis. Tobacco smoking is risk factor for development osteoporosis, and nicotine one major components tobacco. However, mechanism which promotes osteoporosis not fully understood. Here, this study, we found that nicotine-induced mitochondrial oxidative stress DNA (mtDNA) damage osteoblasts differentiated from mouse mesenchymal stem cell. The activity MnSOD, anti-oxidative...
NLRP3 inflammasome activation results in severe liver inflammation and injury. Saikosaponin-d (SSd) possesses anti-inflammatory hepatoprotective effects. This study aimed to determine the protective effects of SSd on carbon tetrachloride (CCl 4 )-induced acute injury mice, whether oxidative stress participate process. The CCl mice model controls were induced. treated with at 1, 1.5, or 2.0 mg/kg a total volume 100 µl/25 g body weight. Liver was assessed by histopathology. Oxidative...
Liver fibrosis is the most common pathway in types of chronic liver damage, characterized by an imbalance ECM degradation and synthesis. Saikosaponin-d (SSd) possesses anti-inflammatory anti-fibrotic effects. However, underlying mechanism which SSd represses hepatic stellate cell (HSC) activation remains unclear. Here, we found that remarkably alleviated carbon tetrachloride (CCl4)-induced fibrosis, as evidenced decreased collagen levels profibrotic marker (COl1a1 α-smooth muscle actin...
Abstract Liver fibrosis, the common response associated with chronic liver diseases, ultimately leads to cirrhosis, a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) by transforming growth factor (TGF)-β1 is key step in fibrosis. Here we report that Kindlin-2 expression elevated livers mice experimental fibrosis and also patients TGF-β1 increases cultured HSCs p38 ERK mitogen-activated protein kinase (MAPK)-dependent manner, partly. More importantly,...
Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation extracellular matrix (ECM), which eventually develop into cirrhosis and cancer. Emerging studies demonstrated that Saikosaponin-d (SSd) exhibits a protective role in fibrosis. However, mechanism underlying anti-liver SSd vivo vitro remains unclear.Transforming growth factor (TGF)-β carbon tetrachloride (CCl4) were used for creating model vivo, respectively. The regulating was assessed...
Saikosaponin-d (SSd) is one of the major triterpenoid saponins derived from Bupleurum falcatum L., which has been reported to possess antifibrotic activity. At present, there little information regarding potential target SSd in hepatic stellate cells (HSCs), serve an important role excessive extracellular matrix (ECM) deposition during pathogenesis fibrosis. Our recent study indicated that may be considered a novel type phytoestrogen with estrogen‑like actions. Therefore, present aimed...
BackgroundThe current definitions and etiologies of acute-on-chronic liver failure (ACLF) are clearly very different between East West.AimsThis study aimed to develop an effective prognostic nomogram for hepatitis B (ACHBLF) as defined by the Asia Pacific Association Study Liver (APASL).MethodsThe was based on a retrospective 573 patients with ACHBLF, according APASL, at Beijing Ditan Hospital. The results were validated using bootstrapped approach correct bias in two external cohorts,...
Background and aims: Saikosaponin d (SSd) has a steroidal structure significant anti-inflammatory effects. The purpose of this study was to explore the mechanism underlying SSd's inhibitory effects on liver fibrosis. Methods: Wild-type estrogen receptor knockout (ERKO) mice were treated with CCl4 establish fibrosis mouse models. SSd hepatic fibrogenesis studied in these Hepatic stellate cells (HSCs) activated by H2O2 investigate potential molecular mechanisms. establishment models degrees...