A5071179531- Glaucoma and retinal disorders
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Coherence Tomography Applications
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Obstructive Sleep Apnea Research
- Radiomics and Machine Learning in Medical Imaging
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Avian ecology and behavior
- MRI in cancer diagnosis
- Psychosomatic Disorders and Their Treatments
- Wildlife Ecology and Conservation
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Retinal and Macular Surgery
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Analysis and Testing Centre
2023-2024
Sichuan University
2023-2024
Nanchang University
2022-2024
Guangzhou Medical University
2021-2023
First Affiliated Hospital of Guangzhou Medical University
2021-2023
Wuhan University of Technology
2023
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
Our purpose was to compare the effectiveness and side effects of a novel, single-piece mandibular advancement device (OSA-Monobloc) for sleep apnea therapy with those two-piece appliance lateral Herbst attachments (OSA-Herbst) as used in previous studies. An OSA-Monobloc an OSA-Herbst equal protrusion were fitted 24 obstructive patients unable use continuous positive airway pressure (CPAP) therapy. After adaptation period 156 +/- 14 d (mean SE), OSA-Monobloc, OSA-Herbst, no random order,...
Purpose.: To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area optic head. Methods.: This experimental study included nine monkeys that underwent implantation a lumbar–peritoneal (CSF) shunt. In group (n = 4 monkeys), shunt was opened to achieve CSF approximately 40 mm H2O, while remained closed in control 5 monkeys). At baseline monthly intervals thereafter, optical coherence...
Abstract Introduction The orbital subarachnoid space surrounding the optic nerve is continuous with circulation system for cerebrospinal fluid (CSF) and can be visualized by using magnetic resonance imaging (MRI). We hypothesized that width (OSASW) correlated serve as a surrogate intracranial pressure (ICP). Our aim was to develop method noninvasive measurement of CSF-pressure (CSF-P) based on MRI-assisted OSASW. Methods prospective observational comparative study included neurology patients...
Nasal prong pressure monitoring (Pnose) is utilized to assess ventilation during sleep. However, it has not been rigorously validated against the gold standard of face-mask pneumotachography (V˙ fm). Therefore, we compared Pnose with V˙ fm in 20 patients suspected sleep apnea nocturnal polysomnography, and analyzed factors affecting accuracy Pnose-derived variables. Patients rated their nasal obstruction on a visual analog scale. Mean ± SE apnea/hypopnea index (AHI) by was 24.0 5.1 h− 1. The...
Abstract Glaucoma is not only an eye disease but also associated with degeneration of brain structures. We now investigated the pattern visual and non-visual structural changes in 25 primary open angle glaucoma (POAG) patients age-gender-matched normal controls using T1-weighted imaging. MRI images were subjected to volume-based analysis (VBA) surface-based (SBA) whole as well ROI-based lateral geniculate nucleus (LGN), cortex (V1/2), amygdala hippocampus. While VBA showed no significant...
Purpose To assess associations of the trans-lamina cribrosa pressure difference (TLCPD) with glaucomatous optic neuropathy. Methods The population-based Central India Eye and Medical Study included 4711 subjects. Based on a previous study lumbar cerebrospinal fluid (CSFP) measurements, CSFP was calculated as CSFP[mmHg] = 0.44 Body Mass Index[kg/m2]+0.16 Diastolic Blood Pressure[mmHg]−0.18×Age[Years] −1.91. TLCPD IOP–CSFP. Results Mean 3.64±4.25 mm Hg in non-glaucomatous population 9.65±8.17...
Purpose.: To analyze the altered amplitude of low-frequency fluctuation (ALFF) brain using resting-state functional magnetic resonance imaging (fMRI) in patients with primary open-angle glaucoma (POAG). Methods.: Resting-state fMRI was conducted 21 POAG and 22 age-matched healthy control subjects. After ALFF fractional (fALFF) for slow 4 5 bands were calculated, results between controls compared. Then correlations ALFF/fALFF values disease stage analyzed. Results.: Compared controls, showed...
Purpose To evaluate the prevalence of diabetic retinopathy and risk factors among patients with self-reported diabetes mellitus in China. Methods The Beijing Eye Study, a population-based study on inhabitants aged 40+ years, included 4439 subjects. Fundus photographs worse eye from participants were graded. Results ready for evaluation filled out questionnaire available 4127 (93.0%) was 235/4127 (5.7%). Among subjects diagnosis diabetes, detected fundus 86 (37.1%) subjects, macular edema 12...
β-N-methylamino-L-alanine (BMAA) is a nonprotein amino acid produced by diverse species of free-living cyanobacteria found in terrestrial and aquatic environments worldwide. BMAA has been detected as soluble (free) insoluble protein-bound (bound) brains Alzheimer's disease, amyotrophic lateral sclerosis, Guamanian sclerosis/Parkinsonism dementia complex patients. A toxic reservoir the brain may be excitotoxic to neurons or serve disrupt cerebral protein homeostasis. Here, we report tracer...
A simple and stable cataluminescence (CTL) sensing platform based on a single material for effective rapid detection of aldehydes is an urgent need due to growing concerns the environment, security, health. Here, user-friendly identification method successfully proposed determine six common homologous compounds via heterothermic CTL sensor system. Using Gd
Purpose To examine potential associations between body height, cerebrospinal fluid pressure (CSFP), trans-lamina cribrosa difference (TLCPD) and prevalence of open-angle glaucoma (OAG) in a population-based setting. Methods The Beijing Eye Study 2011 included 3468 individuals with mean age 64.6±9.8 years (range:50–93 years). A detailed ophthalmic examination was performed. Based on previous study lumbar (CSFP) measurements, CSFP calculated as CSFP[mmHg] = 0.44×Body Mass...
To assess the repeatability and agreement of ocular biometric parameters measured using Tomey CASIA SS-1000 Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices.Both eyes subjects 18 years age or older were scanned three times with under standardized dark lighting. One AS-OCT image along horizontal (temporal-nasal) meridian was analyzed per eye scan. Pupillary diameter (PD) within 15% for all pairwise comparisons. Anterior chamber depth, lens vault, width, angle...
Purpose.: The venous choroidal blood drains through the superior orbital vein into intracranial cavernous sinus. cerebrospinal fluid pressure (CSFP) may thus influence pressure. Since volume and thickness of choroid depend on its pressure, we tested hypothesis whether subfoveal (SFCT) is associated with CSFP. Methods.: population-based Beijing Eye Study 2011 included 3468 individuals. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography...
With the intensification of explosive-based terrorism attack and environmental concerns, innovation high-efficiency portable sensors for facile, rapid, reliable monitoring explosives has become one major demands in societies. Herein, a easy-to-use cataluminescence sensor system based on Dy3+ doping La2O3 nanorod catalysts been developed identification detection six types military explosive vapors, including homologous compounds even isomers. The efficient discrimination is to make full use...
Dopaminergic signaling in the reward pathway brain has been shown to play an important role food intake and development of obesity. Obese rats release less dopamine (DA) nucleus accumbens (NAc) after intake, amphetamine stimulated striatal DA is reduced
To determine the interdependence of intracranial pressure (ICP) and intraocular (IOP) how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into left ventricle, lumbar cistern, subarachnoid space in eye, anterior chamber eye. This allowed ICP, cistern (LCP), (ONSP) IOP to be simultaneously recorded. After establishing baseline levels, changes that resulted from lowering ICP (via shunting cerebrospinal fluid (CSF) ventricle) At baseline,...
Aim To perform an independent validation of deep learning (DL) algorithms for automated scleral spur detection and measurement spur-based biometric parameters in anterior segment optical coherence tomography (AS-OCT) images. Methods Patients receiving routine eye care underwent AS-OCT imaging using the ANTERION OCT system (Heidelberg Engineering, Heidelberg, Germany). Scleral locations were marked by three human graders (reference, expert novice) predicted DL developed Heidelberg Engineering...
Abstract Due to rapid homogenization in habitat types as a result of urbanization, some urban birds adapt their nesting strategies changes local characteristics. Bird decisions might have been mainly linked resource constraints and ensuring reproductive success. In this study, we examined patterns behavior by spotted doves ( Spilopelia chinensis ) rapidly urbanizing area Nanchang, China using ArcGIS 10.8, satellite tracking, camera traps, field survey. To explore the mechanisms underlying...
To examine whether the incidence of retinal vein occlusions (RVOs) is associated with estimated cerebrospinal fluid pressure (CSFP). The population-based Beijing Eye Study, which included 4439 subjects (age: 40 + years) in 2001, was repeated 2011 2695 participating (66.4% survivors). Fundus photographs were examined for new development RVOs, differentiated into central RVOs (CRVOs) and branch (BRVOs). CSFP calculated as [mmHg] = 0.44 × Body Mass Index [kg/m(2) ] 0.16 Diastolic Blood Pressure...
Purpose To assess the effects of age and refractive status on anterior segment anatomical structures, including ciliary body, using a new swept-source optical coherence tomography (AS-OCT) device. Methods This prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images were obtained AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking image averaging from right eye all participants. Repeatability as well inter- intra-observer...