A5043994887- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Optical Coherence Tomography Applications
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Mitochondrial Function and Pathology
- Corneal Surgery and Treatments
- Proteoglycans and glycosaminoglycans research
- Optical Imaging and Spectroscopy Techniques
- Visual perception and processing mechanisms
- Digital Imaging for Blood Diseases
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
University of California, San Diego
2016-2025
University of San Diego
2016-2025
Smith-Kettlewell Eye Research Institute
2016-2024
National Eye Institute
2005-2024
Research to Prevent Blindness
2021-2024
Fleet Science Center
2018-2024
Carl Zeiss (Germany)
2007-2024
Aerie Pharmaceuticals (United States)
2020-2024
Topcon (Netherlands)
2015-2024
Sun Yat-sen University
2022-2024
To examine the prevalence of ocular surface disease (OSD) in glaucoma patients.This was a cross-sectional study. One hundred and one patients, 18 years age or older, with open-angle hypertension were consecutively recruited for Patients history use cyclosporine, steroids, topical nonsteroidal anti-inflammatory drugs, punctal plugs within last 3 months excluded. Each patient completed an Ocular Surface Disease Index questionnaire underwent evaluation by Schirmer test, corneal conjunctival...
• We describe a new technique for the measurement of retinal nerve fiber layer thickness and compare its results with histopathologic measurements in same eyes. For these studies, two fixed monkey eyes were incised placed on pedestal plastic viewing dish. The perfused to maintain pressure between 10 20 mm Hg. An ellipsometer, an optical device used measure change polarization light (retardation), was implemented laser tomographic scanner obtain data from retinas. 15 measured locations,...
Purpose: The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) vasculature measurements in healthy, glaucoma suspect, patients. Methods: Two hundred sixty-one eyes 164 open-angle (OAG) participants from the Diagnostic Innovations Glaucoma Study with good quality OCT-A images were included. Retinal information summarized as a vessel density map (%), which is proportion flowing area over total evaluated....
To characterize the 24-hour pattern of intraocular pressure (IOP) in untreated patients with newly diagnosed early glaucomatous changes.Measurements IOP, blood pressure, and heart rate were taken every 2 hours during a period from group 24 (ages 40-78 years) abnormal optic discs and/or visual fields. In 16-hour diurnal awake period, IOP was measured sitting supine, supine. 8-hour nocturnal sleep all measurements supine position. Mean glaucoma compared data obtained an age-matched control...
<h3>Objective</h3> To identify factors accounting for differences in glaucoma onset and rate of progression between individuals African descent European descent. <h3>Design</h3> A prospective, multicenter observational cohort study 1221 participants with no (normal), suspected glaucoma, glaucoma. Six hundred eighty-six patient the Descent Glaucoma Evaluation Study will be followed up longitudinally. Four thirty-six from Diagnostic Innovations (DIGS) were also included. Baseline demographics,...
Significance Retinal damage and resulting irreversible vision loss are feared complications of rapid substantially elevated intraocular pressure (IOP) in acute glaucoma. An inflammatory response to retinal ischemia/reperfusion injury involving Toll-like receptor 4 (TLR4) IL-1β has been implicated disease pathogenesis; however, the underlying mechanisms remain incompletely understood. This study demonstrates critical role caspase-8 IOP-induced cell death rodent models TLR4 signaling, mediated...
The ability of deep learning architectures to identify glaucomatous optic neuropathy (GON) in fundus photographs was evaluated. A large database (n = 14,822) from a racially and ethnically diverse group individuals (over 33% African descent) evaluated by expert reviewers classified as GON or healthy. Several the impact transfer were best performing model achieved an overall area under receiver operating characteristic (AUC) 0.91 distinguishing eyes healthy eyes. It also AUC 0.97 for...
To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis.One hundred sixteen eyes of 64 patients with who were observed within a period 5 years included. All had at least four serial RNFL measurements obtained the Stratus OCT (Carl Zeiss Meditec, Dublin, CA) and first last separated by 3 years. Visual field (VF) testing was performed on same day as imaging. Serial average RNFLTs evaluated guided analysis (GPA)....