Sonia Jain
A5035524193- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Suicide and Self-Harm Studies
- Resilience and Mental Health
- Cardiac Arrest and Resuscitation
- Posttraumatic Stress Disorder Research
- Kawasaki Disease and Coronary Complications
- Trauma and Emergency Care Studies
- Glaucoma and retinal disorders
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Opioid Use Disorder Treatment
- Coronary Artery Anomalies
- HIV-related health complications and treatments
- Retinal Imaging and Analysis
- Genetic Associations and Epidemiology
- Sex work and related issues
- Child and Adolescent Psychosocial and Emotional Development
- Homelessness and Social Issues
- Hepatitis C virus research
- Advanced Neuroimaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Sleep and related disorders
University of California, San Diego
2016-2025
Human Longevity (United States)
2020-2025
Walter Reed National Military Medical Center
2024
Center for Neuroscience and Regenerative Medicine
2024
University of Maryland, Baltimore
2024
Walter Reed Army Institute of Research
2024
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
General Department of Preventive Medicine
2006-2023
This article proposes a split-merge Markov chain algorithm to address the problem of inefficient sampling for conjugate Dirichlet process mixture models. Traditional Monte Carlo methods Bayesian models, such as Gibbs sampling, can become trapped in isolated modes corresponding an inappropriate clustering data points. describes Metropolis-Hastings procedure that escape local by splitting or merging components. Our employs new technique which appropriate proposal components is obtained using...
Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence persistent functional limitations for these patients is unclear.To characterize the natural history recovery daily function following mTBI vs peripheral orthopedic injury in first 12 months postinjury using data from Transforming Research and Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, and, clinical computed tomographic (CT) scans,...
<h3>Objective</h3> To identify factors accounting for differences in glaucoma onset and rate of progression between individuals African descent European descent. <h3>Design</h3> A prospective, multicenter observational cohort study 1221 participants with no (normal), suspected glaucoma, glaucoma. Six hundred eighty-six patient the Descent Glaucoma Evaluation Study will be followed up longitudinally. Four thirty-six from Diagnostic Innovations (DIGS) were also included. Baseline demographics,...
Background. Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavirboosted protease inhibitors (PI/r). We hypothesized that disoproxil fumarate (TDF)-treated patients taking PI/r-based regimens would have a greater decline in renal function than receiving nonnucleoside reversetranscriptase inhibitor (NNRTI)- based therapy.
To determine whether exposure to repetitive head impacts over a single season affects white matter diffusion measures in collegiate contact sport athletes.A prospective cohort study at Division I NCAA athletic program of 80 nonconcussed varsity football and ice hockey players who wore instrumented helmets that recorded the acceleration-time history following impact, 79 non-contact athletes. Assessment occurred preseason shortly after with tensor imaging neurocognitive measures.There was...
<h3>Importance</h3> Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. <h3>Objective</h3> To ascertain prevalence of PTSD MDD among patients evaluated emergency department mild TBI (mTBI). <h3>Design, Setting, Participants</h3> Prospective longitudinal cohort study...
<h3>Importance</h3> Moderate to severe traumatic brain injury (msTBI) is a major cause of death and disability in the US worldwide. Few studies have enabled prospective, longitudinal outcome data collection from acute chronic phases recovery after msTBI. <h3>Objective</h3> To prospectively assess outcomes areas life function at 2 weeks 3, 6, 12 months <h3>Design, Setting, Participants</h3> This cohort study, as part Transforming Research Clinical Knowledge TBI (TRACK-TBI) was conducted 18...
Posttraumatic stress disorder (PTSD) is a prevalent, serious public health concern, particularly in the military. The identification of genetic risk factors for PTSD may provide important insights into biological foundation vulnerability and comorbidity.To discover loci associated with lifetime 2 cohorts from Army Study to Assess Risk Resilience Servicemembers (Army STARRS).Two coordinated genome-wide association studies mental US military contributed participants. New Soldier (NSS) included...
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are major source disability social economic burden. Both have substantial genetic etiology, partially shared distinct from that related psychiatric disorders.
We report white matter changes after mild traumatic brain injury and their relationship with self-reported cognitive symptoms.
The prognostic value of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-injury predictors functional outcome after traumatic brain injury is not well understood. GFAP a found in cells UCH-L1 neurons, these biomarkers have been cleared to aid decision making regarding whether CT should be performed injury. We aimed quantify their accuracy investigate contribute novel information existing clinical models.
<h3>Importance</h3> Knowledge of differences in mild traumatic brain injury (mTBI) recovery by sex and age may inform individualized treatment these patients. <h3>Objective</h3> To identify sex-related symptom from mTBI; secondarily, to explore within women, who demonstrate poorer outcomes after TBI. <h3>Design, Setting, Participants</h3> The prospective cohort study Transforming Research Clinical Traumatic Brain Injury (TRACK-TBI) recruited 2000 patients with mTBI February 26, 2014, July 3,...
ABSTRACT Background There are no FDA‐approved therapies for alcohol‐associated liver disease (ALD). Preclinical studies indicate that blocking IL‐23/IL‐17 signalling may reverse injury. Guselkumab, an IL‐23‐specific antibody approved psoriasis, be beneficial ALD. Aims We aimed to assess the safety and tolerability of guselkumab in patients with Methods This phase‐1 dose‐escalation study included ≥ 2 DSM‐5 criteria alcohol use disorder, significant steatosis (MRI‐PDFF 8%) MRE < 3.63 kPa...
We examined whether social processes of neighborhoods, such as collective efficacy, during individual's adolescent years affect the likelihood being involved in physical dating violence young adulthood.Using longitudinal data on 633 urban youths aged 13 to 19 at baseline and from their neighborhoods (collected by Project Human Development Chicago Neighborhoods), we ran multilevel linear regression models separately gender assess association between efficacy victimization perpetration,...
<h3>Importance</h3> Mild traumatic brain injury (mTBI) affects millions of Americans each year. Lack consistent clinical practice raises concern that many patients with mTBI may not receive adequate follow-up care. <h3>Objective</h3> To characterize the provision care to during first 3 months after injury. <h3>Design, Setting, and Participants</h3> This cohort study used data on enrolled in Transforming Research Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) between February 26, 2014,...