Nicolás Ramoz
A5008529334- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Attention Deficit Hyperactivity Disorder
- Nerve injury and regeneration
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Adipose Tissue and Metabolism
- Suicide and Self-Harm Studies
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Schizophrenia research and treatment
- Child Nutrition and Feeding Issues
- Child and Adolescent Psychosocial and Emotional Development
- Personality Disorders and Psychopathology
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
Inserm
2016-2025
Université Paris Cité
2016-2025
Institut de Psychiatrie et Neurosciences de Paris
2016-2025
Centre Hospitalier Sainte-Anne
2010-2025
Sorbonne Paris Cité
2016-2024
Assistance Publique – Hôpitaux de Paris
2007-2023
The University of Queensland
2023
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are major source disability social economic burden. Both have substantial genetic etiology, partially shared distinct from that related psychiatric disorders.
Autism/autistic disorder (MIM number 209850) is a complex, largely genetic psychiatric disorder. The authors recently mapped susceptibility locus for autism to chromosome region 2q24-q33 606053). In the present study, genes across interval were analyzed identify an gene in this region.Mutation screening of positional candidate was performed two stages. first stage involved identifying, unrelated subjects showing linkage 2q24-q33, variants exons and flanking sequence within comparing...
The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), most frequent cause mental retardation, have remained elusive. Here we use a transgenic DS mouse model (152F7 line) show DYRK1A gene dosage imbalance deregulates chromosomal clusters genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found Dyrk1a binds SWI/SNF complex known interact with REST/NRSF. mutation REST/NRSF site in promoter target L1cam modifies...
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that secreted in nonconventional, autophagy-dependent fashion. Here, we show low ACBP/DBI plasma concentrations are associated with poor prognosis patients anorexia nervosa, frequent and often intractable eating disorder. In mice, induced chronic restraint stress (CRS) accompanied reduction circulating concentrations. We engineered chemical-genetic system...
<h3>Importance</h3> Breast cancer (BC) diagnosis and treatment expose patients to a 5-fold higher risk of depression compared with the general population, an estimated prevalence 10% 25%. A depressive episode in BC has implications for tolerance adherence treatment, impairing quality life reducing expectancy. <h3>Objective</h3> To identify characterize distinct longitudinal patterns symptoms from 3 years after treatment. <h3>Design, Settings, Participants</h3> The CANTO-DEePRESS (Deeper...
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that more heritable, yet understudied in psychiatric genetics. The authors conducted meta-analyses genome-wide association studies (GWASs) to investigate the genetic architecture PPD. Method: Meta-analyses were on 18 cohorts European ancestry (17,339 PPD cases and 53,426 controls), one cohort East Asian (975 3,780 African (456 1,255 totaling 18,770 58,461 controls. Post-GWAS analyses included 1)...
Background: The D1 dopamine receptor has been involved in a number of brain functions, including motor control, inattentive symptoms and reward reinforcement mechanisms. Indeed, DRD1 antagonists may reduce cocaine‐seeking behavior the acquisition cocaine‐cue associations. D1.1/r4532 marker gene associated with large set phenotypes addictive behaviors, but none alcohol dependence per se. Methods: We analyzed population 134 patients dependence, also assessing more homogeneous (severe)...
Autism spectrum disorders (ASDs) are common, heritable, but genetically heterogeneous neurodevelopmental conditions. We recently defined a susceptibility locus for ASDs on chromosome 1q41-q42. High-resolution single-nucleotide polymorphisms (126 SNPs) genotyping across the 1q41-q42 region, followed by MARK1 (microtubule affinity-regulating kinase 1)-tagged-SNP association study in 276 families with autism from Genetic Research Exchange, showed that several SNPs within gene were significantly...