François Pattou
A5006759849- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Pancreatic and Hepatic Oncology Research
- Body Contouring and Surgery
- Diet, Metabolism, and Disease
- Parathyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Genetic Associations and Epidemiology
- Neuroblastoma Research and Treatments
- Esophageal and GI Pathology
- Hormonal Regulation and Hypertension
- Cannabis and Cannabinoid Research
- Genetics and Neurodevelopmental Disorders
- Obesity and Health Practices
- Cancer, Hypoxia, and Metabolism
Centre Hospitalier Universitaire de Lille
2016-2025
Inserm
2016-2025
Université de Lille
2016-2025
European Genomic Institute for Diabetes
2016-2025
Institut Pasteur de Lille
2015-2025
Institut Pasteur
2020-2025
Hôpital Claude Huriez
2015-2025
Recherche translationnelle sur le diabète
2017-2024
Lille’s Cardiology Hospital
2006-2024
University of Milan
2024
Objective The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity highly prevalent. relation between severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented. Methods This retrospective cohort study analyzed the relationship clinical characteristics, including BMI, requirement for invasive mechanical ventilation (IMV) 124 consecutive patients admitted intensive care SARS‐CoV‐2 a single French center. Results...
OBJECTIVE To describe trends of primary efficacy and safety outcomes islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) 1999 to 2010. RESEARCH DESIGN AND METHODS A total 677 transplant-alone or islet-after-kidney CITR were analyzed for five overall identify any differences by early (1999–2002), mid (2003–2006), recent (2007–2010) transplant era based on annual follow-up 5 years. RESULTS Insulin independence at...
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, resistance, type 2 diabetes (T2D). Studies the processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted meta-analysis genome-wide association tests ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) fasting in 10,701 nondiabetic adults...
Insulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc is required for zinc-insulin crystallization within secretory vesicles. Secreted has also been proposed to be a paracrine and autocrine modulator of glucagon insulin secretion alpha respectively. However, little known about the molecular mechanisms underlying accumulation insulin-containing We previously identified pancreas-specific transporter, ZnT-8, which colocalized with cultured cells. this...
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and nuclear FXR. BA sequestrants (BAS) complex bile in intestinal lumen decrease FXR activity. The BAS–BA also induces glucagon-like peptide-1 (GLP-1) production by L cells potentiates β-cell glucose-induced insulin secretion. Whether is expressed controls GLP-1 unknown. Here, we show that activation decreases proglucagon expression interfering with glucose-responsive factor Carbohydrate-Responsive Element...
Abstract Islets of patients with type 2 diabetes mellitus (T2DM) display features an inflammatory process including elevated levels the cytokine IL-1β, various chemokines, and macrophages. IL-1β is a master regulator inflammation, IL-1 receptor I (IL-1RI) blockage improves glycemia insulin secretion in humans T2DM high-fat-fed mice pointing to pivotal role IL-1RI activity intra-islet inflammation. Given association dyslipidemia T2DM, we tested whether free fatty acids (FFA) promote...
Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type diabetes in subjects of European origin DeCode study. We genotyped two most variants (rs7903146 and rs12255372) 2,367 French diabetic 2,499 control subjects. Both T-allele rs7903146 rs12255372 significantly increase risk an allelic odds ratio (OR) 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) 1.60 (1.47-1.74) 7.6 10(-28)), respectively. In nonobese (BMI <30 kg/m2, n 1,346), ORs increased to 1.89 (1.72-2.09)...