A5061028131- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Diabetes Management and Education
- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Cytomegalovirus and herpesvirus research
- Renal and Vascular Pathologies
- Pluripotent Stem Cells Research
- Bariatric Surgery and Outcomes
- Neurological Complications and Syndromes
- Neuroendocrine Tumor Research Advances
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Heart Rate Variability and Autonomic Control
Mayo Clinic in Arizona
2015-2025
Mayo Clinic
2016-2025
WinnMed
2010-2025
Icahn School of Medicine at Mount Sinai
2023
Harvard University
2023
Sansum Diabetes Research Institute
2023
Texas Diabetes & Endocrinology
2023
Jaeb Center for Health Research
2023
University of Pennsylvania
2023
McLean Hospital
2023
Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.
OBJECTIVE To describe trends of primary efficacy and safety outcomes islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) 1999 to 2010. RESEARCH DESIGN AND METHODS A total 677 transplant-alone or islet-after-kidney CITR were analyzed for five overall identify any differences by early (1999–2002), mid (2003–2006), recent (2007–2010) transplant era based on annual follow-up 5 years. RESULTS Insulin independence at...
Paragangliomas are rare tumors that arise from extraadrenal chromaffin cells. We examined the clinical characteristics, location, treatment, and outcome of 236 patients (141 females, 60%) with 297 benign paragangliomas evaluated at Mayo Clinic during 1978–1998. The mean age (±sd) diagnosis was 47 ± 16 yr. Of paragangliomas, 205 were in head neck region, 92 below neck. discovered diagnosed incidentally on imaging studies 9% patients. Biochemical screening performed 128 patients; 40 (17% total...
<h3>Importance</h3> Continuous glucose monitoring (CGM) provides real-time assessment of levels and may be beneficial in reducing hypoglycemia older adults with type 1 diabetes. <h3>Objective</h3> To determine whether CGM is effective compared standard blood (BGM) <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted at 22 endocrinology practices the United States among 203 least 60 years age <h3>Interventions</h3> Participants were randomly assigned a 1:1 ratio to use...
Evaluation of the existence a diurnal pattern glucose tolerance after mixed meals is important to inform closed-loop system treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 0.0%) determine such in nondiabetic individuals. Identical were ingested during breakfast, lunch, or dinner at 0700, 1300, 1900 h randomized Latin square order on 3 consecutive days. Physical activity was same all Postprandial turnover...
OBJECTIVE—Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO3] and pH) qualitative nature (the presence ketonemia/ketonuria). The present study was undertaken to determine whether quantitative measurement a ketone body anion could be used diagnose DKA. RESEARCH DESIGN AND METHODS—A retrospective review records from hospitalized patients concentration serum β-hydroxybutyrate (βOHB) that corresponds HCO3 level 18 mEq/l,...
The accuracy of continuous interstitial fluid (ISF) glucose sensing is an essential component current and emerging open- closed-loop systems for type 1 diabetes. An important determinant sensor the physiological time lag transport from vascular to space. We performed first direct measurement this phenomenon our knowledge in eight healthy subjects under overnight fasted condition. Microdialysis catheters were inserted into abdominal subcutaneous After intravenous bolus administrations...
Background and Objective: The premise of effective closed-loop insulin therapy for type 1 diabetes (T1D) relies on the accuracy continuous interstitial fluid glucose sensing that represents crucial afferent arm such a system. An important determinant sensor is physiological time lag transport from vascular to space. purpose current studies was determine abdominal subcutaneous space in T1D. Method: Four microdialysis catheters were inserted into 6 T1D subjects under overnight fasted...
Human and animal studies strongly suggest that dietary gluten could play a causal role in the etiopathogenesis of type 1 diabetes (T1D). However, mechanisms have not been elucidated. Recent reports indicate intestinal microbiome has major influence on incidence T1D. Since diet is known to shape composition microbiome, we investigated using non-obese diabetic (NOD) mice whether changes be attributed pro- anti-diabetogenic effects gluten-containing gluten-free diets, respectively. NOD were...
We recently demonstrated a diurnal pattern to insulin action (i.e., sensitivity [SI]) in healthy individuals with higher SI at breakfast than dinner. To determine whether such exists type 1 diabetes, we studied 19 subjects C-peptide–negative diabetes (HbA1c 7.1 ± 0.6%) on pump therapy normal gastric emptying. Identical mixed meals were ingested during breakfast, lunch, and dinner 0700, 1300, 1900 h randomized Latin square of order 3 consecutive days when measured daily physical activity was...
Closed-loop control clinical research trials have been considerably accelerated by in silico using the Food and Drug Administration-accepted type 1 diabetes mellitus (T1DM) simulator. We recently demonstrated that postprandial insulin sensitivity (SI) T1DM subjects was lower at breakfast (B) than lunch (L) dinner (D), but not significantly, because of small population size. The goal this study therefore to incorporate novel information into University Virginia/Padova simulator reproduce...