A5081288689- Diabetes Management and Research
- Pancreatic function and diabetes
- Advanced Control Systems Optimization
- Diabetes and associated disorders
- Fault Detection and Control Systems
- Circadian rhythm and melatonin
- Control Systems and Identification
- Light effects on plants
- Gene Regulatory Network Analysis
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Process Optimization and Integration
- Photoreceptor and optogenetics research
- Heart Rate Variability and Autonomic Control
- Microbial Metabolic Engineering and Bioproduction
- Stress Responses and Cortisol
- Experimental Learning in Engineering
- Mineral Processing and Grinding
- Extremum Seeking Control Systems
- Cardiovascular Function and Risk Factors
- Spaceflight effects on biology
- Anesthesia and Neurotoxicity Research
- Bioinformatics and Genomic Networks
- Advanced Control Systems Design
- Adaptive Control of Nonlinear Systems
Harvard University
2016-2025
Sansum Diabetes Research Institute
2016-2025
Icahn School of Medicine at Mount Sinai
2023
Harvard University Press
2015-2023
Harvard College Observatory
2022
University of California, Santa Barbara
2010-2019
Massachusetts General Hospital
2013-2018
Beijing Jiaotong University
2005-2016
Fraunhofer Institute for Integrated Systems and Device Technology
2016
Ørsted (Denmark)
2016
Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.
Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate function might offer therapeutic approaches to such diseases, only a few compounds have identified selectively target core proteins. From an unbiased cell-based phenotypic screen, we KL001, molecule specifically interacts cryptochrome (CRY). KL001 prevented ubiquitin-dependent degradation CRY, resulting in lengthening period. In combination...
Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with insulin pump (continuous subcutaneous infusion [CSII]), known as artificial pancreas, can help optimize glycemic in diabetes. We present a fundamental modular concept for CLC design, illustrated by clinical studies involving 11 adolescents and 27 adults at the Universities of Virginia, Padova, Montpellier. tested two constructs: standard to range (sCTR), designed augment plus CGM preventing extreme...
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout day. These methods hold significant promise for future discovery, when combined with computational modeling. However, genome-scale experiments are costly laborious, yielding “big data” that conceptually statistically difficult analyze. There is no obvious consensus...
Abstract The significant and growing global prevalence of diabetes continues to challenge people with (PwD), healthcare providers, payers. While maintaining near-normal glucose levels has been shown prevent or delay the progression long-term complications diabetes, a proportion PwD are not attaining their glycemic goals. During past 6 years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials real-world studies that use AID...
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
The ability to continuously monitor the concentration of specific molecules in body is a long-sought goal biomedical research. For this purpose, interstitial fluid (ISF) was proposed as ideal target biofluid because its composition can rapidly equilibrate with that systemic blood, allowing assessment molecular concentrations reflect full-body physiology. In past, continuous monitoring ISF enabled by microneedle sensor arrays. Yet, benchmark sensors only detect undergo redox reactions, which...
Maintenance of glycemic control during and after exercise remains a major challenge for individuals with type 1 diabetes. Glycemic responses to may differ by (aerobic, interval, or resistance), the effect activity on unclear.The Type Diabetes Exercise Initiative (T1DEXI) was real-world study at-home exercise. Adult participants were randomly assigned complete six structured aerobic, resistance sessions over 4 weeks. Participants self-reported nonstudy exercise, food intake, insulin dosing...
Robustness, a relative insensitivity to perturbations, is key characteristic of living cells. However, the specific structural characteristics that are responsible for robust performance not clear, even in genetic circuits moderate complexity. Formal sensitivity analysis allows investigation robustness and fragility properties mathematical models representing regulatory networks, but it yields only local with respect particular choice parameter values. Here, we show by systematically...
Abstract A robust H ∞ controller was developed to deliver insulin via a mechanical pump in Type I diabetic patients. fundamental nonlinear patient model linearized and then reduced third‐order linear form for synthesis. Uncertainty the characterized by up ±40% variation eight physiological parameters. sensitivity analysis identified three‐parameter set having most significant effect on glucose dynamics over frequency range of interest ω = [0.002, 0.2] (rad/min). This uncertainty represented...
Glucose-sensitive poly(methacrylic acid-g-ethylene glycol) (P(MAA-g-EG)) gels were synthesized by copolymerizing methacrylic acid and poly(ethylene monomethacrylate in the presence of activated glucose oxidase. The dynamic equilibrium swelling behavior was examined as a function pH. At low pH values collapsed state due to complexation between carboxyl etheric groups. high values, swelled approximately 20 times their dry weights. oxidase containing exhibited higher rate expansion than non...
Background: Development of an artificial pancreas based on automatic closed-loop algorithm that uses a subcutaneous insulin pump and continuous glucose sensor is goal for biomedical engineering research. However, closing the loop still presents many challenges, including model identification design control will keep type 1 diabetes mellitus subject in normoglycemia longest duration under maximal safety considerations. Method: An pancreatic β-cell zone predictive (zone-MPC) tuned...
Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven autoregulatory feedback loops that lead to oscillating levels of components whose maxima fixed phase relationships with one another. These the key metric characterizing operation clocks. In this study, we built a mathematical model from regulatory structure circadian clock mice identified its parameters using an iterative evolutionary strategy, minimum cost...
OBJECTIVE To evaluate the feasibility of a wearable artificial pancreas system, Diabetes Assistant (DiAs), which uses smart phone as closed-loop control platform. RESEARCH DESIGN AND METHODS Twenty patients with type 1 diabetes were enrolled at Universities Padova, Montpellier, and Virginia Sansum Research Institute. Each trial continued for 42 h. The United States studies conducted entirely in outpatient setting (e.g., hotel or guest house); Italy France hybrid hospital–hotel admissions. A...