A5108050456- Plant Molecular Biology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Plant biochemistry and biosynthesis
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Plant Stress Responses and Tolerance
- Glycosylation and Glycoproteins Research
- Phytochemicals and Antioxidant Activities
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Plant Reproductive Biology
- Insect symbiosis and bacterial influences
- Plant Virus Research Studies
- Lipid metabolism and biosynthesis
- Muscle Physiology and Disorders
- Security and Verification in Computing
- Protein Hydrolysis and Bioactive Peptides
- Immune cells in cancer
- Immune Cell Function and Interaction
Zhejiang Ocean University
2023-2025
Xinjiang Medical University
2024-2025
Shanghai Jiao Tong University
2025
Beijing Academy of Artificial Intelligence
2025
Hunan Agricultural University
2025
Jiangsu Province Hospital
2019-2025
Nanjing Medical University
2019-2025
Zunyi Medical University
2025
Hangzhou First People's Hospital
2025
Westlake University
2025
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout day. These methods hold significant promise for future discovery, when combined with computational modeling. However, genome-scale experiments are costly laborious, yielding “big data” that conceptually statistically difficult analyze. There is no obvious consensus...
In this paper, a novel donor–acceptor pair was creatively proposed based on the principle of electrochemiluminescence resonance energy transfer (ECL-RET): luminol immobilized polyethyleneimine (PEI)-functionalized manganese-based single-atom nanozymes (Mn SANE/PEI-luminol, donor) and PtCu-grafted hollow metal polydopamine framework (PtCu/h-MPF, acceptor). A quenched ECL immunosensor constructed for ultrasensitive analysis carcinoembryonic antigen (CEA). Mn SANE, as an efficient coreaction...
Abstract Cold stress is a major meteorological threat to crop growth and yield. Abscisic acid (ABA) plays important roles in plant cold tolerance by activating the expression of cold‐responsive genes; however, underlying transcriptional regulatory module remains unknown. Here, we demonstrated that cold‐ ABA‐responsive transcription factor ETHYLENE RESPONSE FACTOR 15 (ERF15) positively regulates ABA‐mediated tomato. Exogenous ABA treatment significantly enhanced wild‐type tomato plants but...
Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others. Even monogenic muscular dystrophies selectively certain groups. These observations suggest that factors intrinsic to influence their resistance disease. Nevertheless, most studies have not addressed transcriptional diversity among skeletal muscles. Here we use RNAseq profile mRNA expression in skeletal, smooth,...
Tumor metastasis occurs naturally in pancreatic cancer, and the efficacy of chemotherapy is usually poor. Precision medicine, combining downregulation target genes with drugs, expected to improve therapeutic effects. Therefore, we developed a combined therapy micro RNA ‐21 antisense oligonucleotides ( ASO ‐miR‐21) gemcitabine (Gem) using targeted co‐delivery nanoparticle NP ) carrier investigated synergistic inhibitory effects on cancer cells growth. Polyethylene...
The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N
Abstract Flavonoids are the most widespread polyphenolic compounds and important dietary constituents present in horticultural crops such as fruits, vegetables, tea. Natural flavonoids responsible for quality traits, food colors beneficial antioxidants, numerous investigations have shown that intake of can reduce incidence various non-communicable diseases. Analysis thousands reported so far has different hydroxylation modifications affect their chemical properties nutritional values. These...
ER-phagy is a form of autophagy that mediated by receptors and selectively degrades endoplasmic reticulum (ER). Coronaviruses have been shown to use the ER as membrane source establish their double-membrane vesicles (DMVs). However, whether viruses modulate drive viral DMV formation its underlying molecular mechanisms remains largely unknown. Here, we demonstrate coronavirus subverts hijacking FAM134B ATL3 into p62 condensates, resulting in increased replication. Mechanistically, show...
Abstract Lipid droplets (LDs) form inter‐organelle contacts with the endoplasmic reticulum (ER) that promote their biogenesis, while LD mitochondria enhance β‐oxidation of contained fatty acids. Viruses have been shown to take advantage lipid viral production, but it remains unclear whether they also modulate interactions between LDs and other organelles. Here, we showed coronavirus ORF6 protein targets is localized mitochondria‐LD ER‐LD contact sites, where regulates biogenesis lipolysis....
THP-1 monocyte, which can be differentiated into macrophages by PMA, is widely used in researches on pathogen infection and host innate immunity, but reports the induction methods of PMA are different lack a unified standard, transcriptome characteristics macrophage compared with cells remains unclear. In this research, we examined differentiation effect three factors including time, cell seeding density concentration detecting positive rate CD14 expression. The 80ng/ml time 24h, 5×10 5...
Ribonuclease (RNA) modifications can alter cellular function and lead to differential immune responses by acting as discriminators between RNAs from different phyla. RNA glycosylation has recently been observed at the cell surface, its dysregulation in disease may change functions. However, determining which substrates be glycosylated remains explored. Here, we develop a solid-phase chemoenzymatic method (SPCgRNA) for targeting RNAs, specifically recognized. We found N-glycosylation of small...
Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer-associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated of CAF-derived extracellular vesicle (EV)-packaged long non-coding RNAs (lncRNAs) and explored gene therapy using engineered EVs loading small interfering (siRNAs) as potential therapeutic strategy. Our findings highlight significance EV-packaged lncRNA...
Reactive oxygen species-induced vessel endothelium injury is crucial in cardiovascular diseases progression. Rice-derived bran bioactive peptides (RBAP) might exert antioxidant effect through unknown mechanisms. Herein, we validated the and mechanism of RBAP on H2O2-induced oxidative human umbilical vein endothelial cells (HUVECs). Here, HUVECs were treated with under H2O2 stimulation; effects evaluated. injury-induced cell morphology changes ameliorated by RBAP. The H2O2- HUVEC apoptosis...
Scope Regulating the gut microecology by probiotics is an efficient strategy to rational prevention and treatment of Alzheimer's disease (AD). However, there currently a lack well‐known probiotic species in protection against AD, involved mechanism has not been clearly interpreted. Methods results Herein, Lactobacillus plantarum MA2 (MA2), functional isolated from traditional Chinese Tibetan kefir grains, demonstrated improve cognitive deficits anxiety‐like behaviors d ‐galactose/AlCl 3...
Java deserialization vulnerability is a severe threat in practice. Researchers have proposed static analysis solutions to locate candidate vulnerabilities and fuzzing generate proof-of-concept (PoC) serialized objects trigger them. However, existing limited effectiveness efficiency.In this paper, we propose novel hybrid solution ODDFuzz efficiently discover vulnerabilities. First, performs lightweight taint identify gadget chains that may cause In step, tries all candidates avoid false...
Interferon regulatory factor 2 (IRF2) participates in the differentiation of immune T cells. Bone marrow mesenchymal stem cell (BM-MSC)-derived exosomes can secret mRNA, miRNAs, and proteins to regulate tumor microenvironment. The present study focused on miRNA/IRF2 axis regulating Th1/Th2 ratio apoptosis acute myeloid leukemia (AML). flow cytometry analysis was performed examine AML vivo vitro. contents γ (IFN-γ) Interleukin-4 (IL-4) were measured using enzyme-linked immunosorbent assay....