A5103089991- Circadian rhythm and melatonin
- Light effects on plants
- Neurobiology and Insect Physiology Research
- Plant Molecular Biology Research
- Music Technology and Sound Studies
- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
- Parallel Computing and Optimization Techniques
- Music and Audio Processing
- Developmental Biology and Gene Regulation
- Sleep and Wakefulness Research
- Chromosomal and Genetic Variations
- Distributed systems and fault tolerance
- Advanced Data Storage Technologies
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- Neuroscience and Music Perception
- Genomics and Chromatin Dynamics
- Photoreceptor and optogenetics research
- Distributed and Parallel Computing Systems
- RNA Research and Splicing
- Insect and Arachnid Ecology and Behavior
- Psychological and Temporal Perspectives Research
- Cloud Computing and Resource Management
Rockefeller University
2014-2023
NIHR Bristol Cardiovascular Biomedical Research Unit
2022
Brandeis University
2017
Australian National University
2015
Goldsmiths University of London
2004-2013
St George's, University of London
2009-2010
University of Virginia
2006
University of London
2004
University of California, Irvine
1988-2003
U.S. National Science Foundation
1994-2001
Eclosion, or emergence of adult flies from the pupa, and locomotor activity adults occur rhythmically in Drosophila melanogaster , with a circadian period about 24 hours. Here, clock mutation, timeless ( tim ), is described that produces arrhythmia for both behaviors. The effects on behavioral rhythms are likely to involve products X chromosome-linked gene per because alters oscillations RNA. Genetic mapping places left arm second chromosome between dumpy dp ) decapentaplegic dpp ).
Two genes, period ( per ) and timeless tim ), are required for production of circadian rhythms in Drosophila . The proteins encoded by these genes (PER TIM) physically interact, the timing their association nuclear localization is believed to promote cycles transcription through an autoregulatory feedback loop. Here it shown that TIM protein may also couple this molecular pacemaker environment, because rapidly degraded after exposure light. accumulated rhythmically nuclei eyes cells brain....
Loss of any one several neurogenic genes Drosophila results in overproduction embryonic neuroblasts at the expense epidermoblasts. In this paper a variety altered Notch proteins are expressed transgenic flies. Dominant lethal, antineurogenic phenotypes were produced by expression three classes mutant proteins: (1) protein comprised cytoplasmic domain and devoid sequences permitting membrane association; (2) transmembrane lacking extracellular, lin12/Notch repeats; (3) carrying amino acid...
This paper is about repeated gene families in Drosophila melanogaster. A family consists of many identical or nearly genes that cohabit a single haploid genome. In some cases the are contained within tandemly DNA units. Indeed, successive observations 18S and 28S rRNA Xenopus laevis (Brown Weber 1968; Birnstiel et al. Miller Beatty 1969), 5S RNA this frog 1971), histone sea urchins (reviewed by Kedes 1976) all created an illusion generally assume such tandem topographies. It true these three...
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout day. These methods hold significant promise for future discovery, when combined with computational modeling. However, genome-scale experiments are costly laborious, yielding “big data” that conceptually statistically difficult analyze. There is no obvious consensus...
The clock gene timeless ( tim ) is required for circadian rhythmicity in Drosophila . accumulation of RNA followed a rhythm, and the phase period rhythm were indistinguishable from those that have been reported per oscillations found to be dependent on presence PER TIM proteins, which demonstrates feedback control by mechanism previously shown regulate expression. cyclic expression appears dictate timing protein nuclear localization, suggesting promotes rhythms transcription restricting...
The period ( per ) gene likely encodes a component of the Drosophila circadian clock. Circadian oscillations in abundance messenger RNA and protein (PER) are thought to arise from negative feedback control transcription by PER. A recently identified second clock locus, timeless tim ), apparently regulates entry PER into nucleus. Reported here cloning complementary DNAs derived two-hybrid screen for PER-interacting proteins demonstration physical interaction between (TIM) vitro. restricted...
In wild-type Drosophila , the period protein (PER) is found in nuclei of eyes and brain, PER immunoreactivity oscillates with a circadian rhythm. The studies described here indicate that nuclear localization blocked by timeless ( tim ), second chromosome mutation that, like per null mutations, abolishes rhythms. fusion proteins without conserved domain (PAS) some flanking sequences are mutants. This suggests segment inhibits gene may have role establishing rhythms abundance flies.
The Drosophila genes timeless ( tim ) and period per interact, both are required for production of circadian rhythms. Here the positional cloning sequencing reported. gene encodes a previously uncharacterized protein 1389 amino acids, possibly another 1122 acids. arrhythmic mutation 01 is 64-base pair deletion that truncates TIM to 749 Absence sequence similarity PER dimerization motif (PAS) indicates direct interaction between would require heterotypic association.
This paper describes the design and implementation of virtual memory management within CMU Mach Operating System experiences gained by kernel group in porting that system to a variety architectures. As this writing, runs on more than half dozen uniprocessors multiprocessors including VAX family multiprocessors, IBM RT PC, SUN 3, Encore MultiMax, Sequent Balance 21000 several experimental computers. Although these systems vary considerably kind hardware support for they provide,...