A5017090852- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Advanced MRI Techniques and Applications
- Clinical Nutrition and Gastroenterology
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Mobile Health and mHealth Applications
- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Consumer Attitudes and Food Labeling
- Obesity and Health Practices
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus
2017-2024
Diabetes Australia
2023
Institute of Social and Preventive Medicine
2022
Bahçeşehir University
2022
Swiss Paraplegic Research
2022
Shahid Sadoughi University of Medical Sciences and Health Services
2022
Leiden University Medical Center
2022
University of St. Gallen
2021
BackgroundThe achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness day-and-night hybrid closed-loop insulin delivery compared sensor-augmented pump therapy in people suboptimally controlled diabetes aged 6 years and older.MethodsIn this open-label, multicentre, multinational, single-period, parallel randomised trial, participants were recruited from outpatient clinics at four hospitals UK two centres USA. randomly assigned...
Abstract The significant and growing global prevalence of diabetes continues to challenge people with (PwD), healthcare providers, payers. While maintaining near-normal glucose levels has been shown prevent or delay the progression long-term complications diabetes, a proportion PwD are not attaining their glycemic goals. During past 6 years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials real-world studies that use AID...
In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) improve glucose control in type 1 diabetes. We wanted to investigate whether could also 2 diabetes who were receiving noncritical care.In this randomized, open-label trial conducted on general wards two tertiary hospitals located United Kingdom and Switzerland, we assigned 136 adults required...
Comparing the performance of different continuous glucose monitoring (CGM) systems is challenging due to lack comprehensive guidelines for clinical study design. In particular, absence concise requirements distribution comparator (reference) blood (BG) concentrations and their rate change (RoC) that are used evaluate CGM performance, impairs comparability. For this article, several experts in field testing have collaborated propose characteristics measurements should be collected during...
Tight control of blood glucose concentration in people with type 1 diabetes predisposes to hypoglycaemia. We aimed investigate whether day-and-night hybrid closed-loop insulin delivery can improve while alleviating the risk hypoglycaemia adults HbA
A deep learning network was used to predict future blood glucose levels, as this can permit diabetes patients take action before imminent hyperglycaemia and hypoglycaemia. sequential model with one long-short-term memory (LSTM) layer, bidirectional LSTM layer several fully connected layers levels for different prediction horizons. The method trained tested on 26 retrospectively analysed datasets from 20 real patients. proposed outperforms the baseline methods in terms of all evaluation criteria.
Glucose management is challenging in patients who require nutritional support hospital. We aimed to assess whether fully closed-loop insulin delivery would improve glycaemic control compared with conventional subcutaneous therapy inpatients receiving enteral or parenteral nutrition both.
Abstract We evaluated the safety and efficacy of fully closed-loop insulin therapy compared with standard in adults type 2 diabetes requiring dialysis. In an open-label, multinational, two-center, randomized crossover trial, 26 dialysis (17 men, 9 women, average age 68 ± 11 years (mean s.d.), duration 20 10 years) underwent two 20-day periods unrestricted living, comparing Cambridge system using faster aspart (‘closed-loop’) a masked continuous glucose monitor (‘control’) random order. The...
To evaluate the use of hybrid closed-loop glucose control with faster-acting insulin aspart (Fiasp) in adults type 1 diabetes (T1D).
Diabetes Technology Society organized an expert consensus panel to develop metrics for research in the use of continuous glucose monitors (CGMs) a hospital setting. The experts met virtually small groups both before and after April 13, 2023 virtual meeting entire panel. goal was definitions anticipation greater CGMs settings future. Establishment inpatient analytical will be easier compare outcomes between studies. Panelists defined terms related 10 dimensions measurements including (1)...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
Inpatient diabetes management of those on hemodialysis poses a major challenge. In post hoc analysis randomized controlled clinical trial, we compared the efficacy fully automated closed-loop insulin delivery vs. usual care in patients undergoing while hospital. Compared to control receiving conventional subcutaneous therapy, significantly increased proportion time when continuous glucose monitor was target range 5.6-10.0 mmol/l by 37.6 percent without increasing risk hypoglycemia. Thus,...
OBJECTIVE To quantify age-related variability of insulin needs during day and night closed-loop delivery. RESEARCH DESIGN AND METHODS We retrospectively analyzed data from hybrid studies involving young children (1–6 years old, n = 20), (7–12 years, 21), adolescents (13–17 15), adults (>18 58) with type 1 diabetes. The coefficient variation quantified 3 weeks unrestricted-living use. RESULTS Data 2,365 nights 2,367 days in 114 participants were analyzed. delivery was higher compared...
Abstract The liver plays a central role in metabolic homeostasis, as exemplified by variety of clinical disorders with hepatic and systemic disarrays. Of particular interest are the complex interactions between lipid carbohydrate metabolism highly prevalent conditions such obesity, diabetes, fatty disease. Limited accessibility need for invasive procedures challenge direct investigations humans. Hence, noninvasive dynamic evaluations glycolytic flux steady‐state assessments levels...
Unhealthy dietary habits are a major preventable risk factor for widespread non-communicable diseases (NCD). Diet counseling is effective in managing diet-related NCDs, but constrained by its manual nature and limited (clinical) resources. To address these challenges, we propose fully automated diet system FoodCoach. It monitors people's food purchases using digital receipts from loyalty cards provides structured recommendations. We introduce the FoodCoach system's recommender algorithm...
Introduction Kidney stones are a global healthcare problem. Given high recurrence rates and the morbidity associated with symptomatic stone disease, effective medical prophylaxis is clearly an unmet need. Explanatory analyses of randomised controlled trials sodium/glucose cotransporter isoform 2 inhibitors indicated 30%–50% reduced rate events in patients diabetes. Underlying mechanisms remain unclear. We aim to determine effect empagliflozin on urinary supersaturations non-diabetic kidney...