A5055218218- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Muscle metabolism and nutrition
- MRI in cancer diagnosis
- Diet, Metabolism, and Disease
- Atomic and Subatomic Physics Research
- Mitochondrial Function and Pathology
- Cardiovascular and exercise physiology
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Neonatal and fetal brain pathology
- Traumatic Brain Injury Research
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
University of Bern
2016-2025
University Hospital of Bern
2012-2024
University Hospital of Zurich
2019
Resonance Research (United States)
1997-2018
Mayo Clinic
2018
University of Lausanne
2006-2015
University of Minnesota
2014
Max Planck Institute for Biological Cybernetics
2012
Max Planck Society
2012
Ludwig Boltzmann Institute for COPD And Respiratory Epidemiology
2011
Abstract Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while peak ratios short echo time spectra evaluated 173 examinations. Normative curves for normal development established two cerebral locations. The current report presents the first study absolute T 1 ‐and 2 ‐relaxation as a function age. Myo ‐inositol was found dominating at birth (12 mmoles/kg), choline is responsible strongest older...
The origin of auditory hallucinations, which are one the core symptoms schizophrenia, is still a matter debate. It has been hypothesized that alterations in connectivity between frontal and parietotemporal speech-related areas might contribute to pathogenesis hallucinations. These networks assumed become dysfunctional during generation monitoring inner speech. Magnetic resonance diffusion tensor imaging relatively new vivo method investigate directionality cortical white tracts.To...
Abstract Intra‐myocellular lipids (IMCL) are stored in droplets the cytoplasm of muscle cells and an energy storage form readily accessed during long‐term exercise. 1 H‐MR spectroscopy methods presented for noninvasive determination IMCL human muscle. This is based on (a) separation two resonances lipid‐CH 2 ‐region, with one assigned to being independent orientation relative magnetic field (b) fact that scale along signal amplitudes metabolites cell (e.g., creatine) when voxel size...
Once an MRS dataset has been acquired, several important steps must be taken to obtain the desired metabolite concentration measures. First, data preprocessed prepare them for analysis. Next, intensity of signal(s) interest estimated. Finally, measured signal intensities converted into scaled units employing a quantitative reference allow meaningful interpretation. In this paper, we review these three main in post‐acquisition workflow single‐voxel experiment (preprocessing, analysis and...
The translation of MRS to clinical practice has been impeded by the lack technical standardization. There are multiple methods acquisition, post‐processing, and analysis whose details greatly impact interpretation results. These often not fully reported, making it difficult assess studies on a standardized basis. This hampers reviewing manuscripts, limits reproducibility study results, complicates meta‐analysis literature. In this paper consensus group experts provides minimum guidelines for...
Proton magnetic resonance (MR) spectroscopy of the brain was performed in 11 patients with chronic hepatic encephalopathy (CHE), and results were compared those liver disease but without CHE; clinical control subjects diabetes, uremia, or cortical atrophy; healthy subjects. The technique water-suppressed stimulated-echo hydrogen-1 MR for detection cerebral glutamate, glutamine, glucose, N-acetylaspartate, choline metabolites, (phospho)creatine, myo-inositol is described. Specific changes CHE...
Large neutral amino acids (LNAAs), including phenylalanine (Phe), compete for transport across the blood-brain barrier (BBB) via L-type acid carrier. Accordingly, elevated plasma Phe impairs brain uptake of other LNAAs in patients with phenylketonuria (PKU). Direct effects and depleted are probably major causes disturbed development function PKU. Competition carrier might conversely be put to use lower influx when concentrations all increased. This hypothesis was tested by measuring PKU...
Biochemical maturation of the brain can be studied noninvasively by (1)H magnetic resonance spectroscopy (MRS) in human infants. Detailed time courses cerebral tissue contents are known for most abundant metabolites only, and whether or not premature birth affects biochemical is disputed. Hence, last trimester gestation was observed infants born prematurely, their metabolite at expected term were compared with those fullterm Successful quantitative short-TE MRS performed three locations 21...
PURPOSE: To determine whether hydrogen-1 magnetic resonance (MR) spectroscopy of the brain allows detection subclinical hepatic encephalopathy (SCHE). MATERIALS AND METHODS: In a double-blind study, overt (HE) and SCHE (defined with clinical neuropsychiatric tests) were compared by means H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) choline SDs or without increased glutamine (> 1 SD normal)--in 20 patients cirrhosis. RESULTS:...
Abstract The objective of this study was to demonstrate 1 H MR spectroscopy (MRS) changes in cerebral metabolites after acute head trauma. Twenty‐five patients (12 children, 13 adults) were examined with quantitative MRS closed injury. Clinical grade (Glasgow Coma Scale [GCS]) and outcome (Rancho Los Amigos Medical Center Outcome Score [ROS]) correlated neurochemical findings. N‐acetylas‐partate (NAA), a neuronal axonal marker, reduced ( P < .03−.001). In NAA/creatine plus phosphocreatine...
Localized proton magnetic resonance (MR) spectroscopy was used to define biochemical changes in gray and white matter of the cerebral cortex 22 patients with diabetes mellitus (DM), including 10 episodes diabetic ketoacidosis (DKA), compared MR spectra 30 healthy subjects. Five distinct metabolic abnormalities were identified: Concentrations glucose (Glc) (P greater than or equal .002), ketone body bodies, myo-inositol .003) (with without glycine), choline (Cho) metabolites increased both...
Abstract Localized, short echo 1 H magnetic resonance spectra from an area in the parietal cortex of three patients suffering chronic hepatic encephalopathy are compared with equivalent obtained healthy control subjects. Three significant differences found: elevated glutamine, decreased inositol, and choline peak intensities. The elevation cerebral glutamine concentration is expected as a consequence presumed hyperammonemia this disease. finding 50% change inositol physiologically unexpected...
Consumption of simple carbohydrates has markedly increased over the past decades, and may be involved in prevalence metabolic diseases. Whether an intake fructose is specifically related to a dysregulation glucose lipid metabolism remains controversial. We therefore compared effects hypercaloric diets enriched with (HFrD) or (HGlcD) healthy men. Eleven subjects were studied randomised order after 7 d following diets: (1) weight maintenance, control diet; (2) HFrD (3·5 g fructose/kg fat-free...
To assess how intrahepatic fat and insulin resistance relate to daily fructose energy intake during short-term overfeeding in healthy subjects.The analysis of the data collected several studies which fasting hepatic glucose production (HGP), sensitivity index (HISI), intrahepatocellular lipids (IHCL) had been measured after both 6-7 days on a weight-maintenance diet (control, C; n = 55) with 1.5 (F1.5, 7), 3 (F3, 17), or 4 g fructose/kg/day (F4, 10), glucose/kg/day (G3, 11), 30% excess as...
Sarcopenia is thought to be associated with mitochondrial (Mito) loss. It unclear whether the decrease in Mito content consequent aging per se or decreased physical activity.The objective of study was examine influence fitness on and function assess exercise could improve older adults.Three distinct studies were conducted: 1) a cross-sectional observation comparing large heterogeneous cohort adults; 2) case-control chronically endurance-trained adults sedentary (S) subjects matched for age...