A5074844173- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Metabolomics and Mass Spectrometry Studies
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Electron Spin Resonance Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Lanthanide and Transition Metal Complexes
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury Research
- Brain Tumor Detection and Classification
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Epilepsy research and treatment
- Infrared Thermography in Medicine
- Thermal Regulation in Medicine
- Optical Imaging and Spectroscopy Techniques
University of Miami
2015-2025
Emory University
2025
Northwestern University
2025
Duke University
2025
Sylvester Comprehensive Cancer Center
2016
Resonance Research (United States)
2013-2014
University of Minnesota
2014
Fayetteville State University
2013
University of Oxford
2013
University of California, San Francisco
1996-2007
Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or vitro studies of mammalian brain. Measurements were obtained using high-field spectra solution, under conditions typical normal physiological temperature pH. This information is with an accuracy suitable computer simulation metabolite to used as basis functions a parametric spectral analysis procedure. procedure verified the rat brain extract spectrum, measured parameters. In...
Application of the new nuclear magnetic resonance (NMR) method fast scan proton imaging is described. Cross sectional scans a human finger in vivo are measured and reveal considerable anatomical detail, particularly soft tissue regions. Imaging tumour also briefly discussed.
The translation of MRS to clinical practice has been impeded by the lack technical standardization. There are multiple methods acquisition, post‐processing, and analysis whose details greatly impact interpretation results. These often not fully reported, making it difficult assess studies on a standardized basis. This hampers reviewing manuscripts, limits reproducibility study results, complicates meta‐analysis literature. In this paper consensus group experts provides minimum guidelines for...
Abstract Distributions of proton MR‐detected metabolites have been mapped throughout the brain in a group normal subjects using volumetric MR spectroscopic imaging (MRSI) acquisition with an interleaved water reference. Data were processed intensity and spatial normalization to enable voxel‐based analysis methods be applied across subjects. Results demonstrate significant regional, tissue, gender‐dependent variations metabolite concentrations, these distributions aging. The greatest...
Abstract An automated method for analysis of in vivo proton magnetic resonance (MR) spectra and reconstruction metabolite distributions from MR spectroscopic imaging (MRSI) data is described. A parametric spectral model using acquisition specific, a priori information combined with wavelet‐based, nonparametric characterization baseline signals. For image reconstruction, the initial fit estimates were additionally modified according to spatial constraints. The fitting procedure was applied...
Abstract Temporal lobe epileptogenic foci were blindly localized in 8 patients with medically refractory unilateral complex partial seizures using noninvasive vivo proton magnetic resonance spectroscopic imaging ( 1 H‐MRSI) 4‐ml effective voxel size. The brain metabolite signals matched normal controls bilaterally symmetrical within ± 10%. hippocampal seizure had 21 5% less N ‐acetyl aspartate signal than the contralateral formations p < 0.01). focal reductions consistent pathology...
Abstract The goals of the current study were threefold: first, to confirm previous single volume proton ( 1 H) magnetic resonance spectroscopy results reduced N ‐acetyl aspartate (NAA, a putative marker neurons) in multiple sclerosis (MS) white matter lesions using H spectroscopic imaging (MRSI); second, measure phospholipid metabolites phosphomonoesters and phosphodiesters such phosphorus 31 P) MRSI; third, test hypothesis that biochemical changes occur normal‐appearing (on spin echo...
Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires specialized spatial and spectral data processing methods benefits from the use of several sources prior information that are not commonly available, including MRI-derived tissue segmentation, morphological analysis characteristics observed metabolites. In addition, incorporating obtained MRI can enhance display low-resolution metabolite images multiparametric regional statistical improve detection altered...
Two-dimensional proton magnetic resonance (MR) spectroscopic imaging studies were performed of the distributions major hydrogen-1 metabolites choline, creatine, N-acetyl aspartate (NAA) and lactate in normal (n = 6) subacutely to chronically infarcted 10) human brain. The two dimensions phase encoding applied over a 20-mm-thick section brain tissue that had been selected with double spin-echo localization method. Normal showed bilaterally symmetric metabolite no detectable lactate. Nine 10...
A new fast scanning method of producing proton density images by NMR is described which could be useful for the examination plants as well biological tissue in vivo. Examples are given produced from small samples plant and material. Calculations show that imaging equipment, if scaled to deal with objects human proportions, under ideal conditions produce pictures close television quality times ranging down a few minutes this method.
Surgicale report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and patients with a variety pathological lesions. We have used 1.5 T NMR magnet system. When compared proton distribution, sodium, shows greater vriation its concentration from tissue to conditions. Image contrast calculated on basis is 7 18 times than that spin density. Normal emphasize extracellular compartments. In studies, areas recent or old infarction tumors...
Changes in the distribution of magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and creatine (Cre), following mild-to-moderate closed-head traumatic injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies carried out during subacute time period injury, associations metabolite indices with neuropsychological test (NPT) results evaluated. Twenty-nine subjects mTBI Glasgow Coma Scale (GCS) scores 10–15...
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined the research community limited number of sites. The MRSI currently implemented MRI instruments remained essentially unchanged two decades, only incremental improvements in sequence implementation. During this time,...
With a 40‐year history of use for in vivo studies, the terminology used to describe methodology and results magnetic resonance spectroscopy (MRS) has grown substantially is not consistent many aspects. Given platform offered by this special issue on advanced MRS methodology, authors decided implicated terms, pinpoint differences their meanings suggest specific uses or definitions. This work covers terms all aspects MRS, starting from description MR signal its theoretical basis acquisition...
Quantitative measurements of regional and tissue specific concentrations brain metabolites were measured in elderly subjects using multislice proton magnetic resonance spectroscopic imaging ((1)H MRSI). Selective k-space extrapolation an inversion-recovery sequence used to minimize lipid contamination linear regression was account for partial volume problems. The technique applied measure the N-acetyl aspartate (NAA), creatine (Cr)- choline (Cho)-containing compounds cortical gray white...
Abstract The effect of different spatial‐encoding ( k ‐space) sampling distributions are evaluated for magnetic resonance spectroscopic imaging (MRSI) using Fourier reconstruction. Previously, most MRSI studies have used square or cubic ‐space functions, symmetrically distributed. These examine the conventional distribution with spherical distribution, and 1/2 acquisition, computer simulation acquisition three spatial dimensions experimental results. Results compare response function, Gibbs...