A5103068271- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Thermal Regulation in Medicine
- Pain Management and Treatment
- Opioid Use Disorder Treatment
- Grief, Bereavement, and Mental Health
- Health, psychology, and well-being
- Pain Management and Opioid Use
- Cardiac Health and Mental Health
- Advanced MRI Techniques and Applications
- Forgiveness and Related Behaviors
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Religion, Spirituality, and Psychology
- Long-Term Effects of COVID-19
- Infrared Thermography in Medicine
- Myofascial pain diagnosis and treatment
- Attachment and Relationship Dynamics
- Transcranial Magnetic Stimulation Studies
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Mental Health and Psychiatry
University of Alabama at Birmingham
2016-2025
Stanford University
2006-2017
Creative Commons
2017
October 6 University
2017
Palo Alto University
2007-2015
Stanford Medicine
2009-2014
Politecnico di Milano
2013
Kawasaki Medical School
2013
Region Blekinge
2013
Arista (United States)
2013
Significance Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) devastates the lives of millions people and has remained a mystery illness despite decades research. It long been suspected that inflammation is central to its pathogenesis. Although only two cytokines were found be different (TGF-β higher resistin lower) in ME/CFS patients compared with controls, 17 correlated severity. Thirteen these are proinflammatory may contribute many symptoms experience for several years. Only...
Fibromyalgia is a chronic pain disorder that characterized by diffuse musculoskeletal and sensitivity to mechanical stimulation. In this pilot clinical trial, we tested the effectiveness of low-dose naltrexone in treating symptoms fibromyalgia.Participants completed single-blind, crossover trial with following time line: baseline (2 weeks), placebo drug (8 washout weeks).Ten women meeting criteria for fibromyalgia not taking an opioid medication.Naltrexone, addition antagonizing receptors on...
Chronic low back pain (cLBP) has a tremendous personal and socioeconomic impact, yet the underlying pathology remains mystery in majority of cases. An objective measure this condition, that augments self-report pain, could have profound implications for diagnostic characterization therapeutic development. Contemporary research indicates cLBP is associated with abnormal brain structure function. Multivariate analyses shown potential to detect number neurological diseases based on structural...
Chronic opioid exposure is known to produce neuroplastic changes in animals; however, it not if opioids used over short periods of time and at analgesic dosages can similarly change brain structure humans. In this longitudinal, magnetic resonance imaging study, 10 individuals with chronic low back pain were administered oral morphine daily for 1 month. High-resolution anatomical images the acquired immediately before after administration period. Regional gray matter volume assessed on whole...
Myofascial pain of the temporomandibular region (M-TMD) is a common, but poorly understood chronic disorder. It unknown whether condition peripheral problem, or disorder central nervous system (CNS). To investigate possible CNS substrates M-TMD, we compared brain morphology 15 women with M-TMD to that age- and gender-matched healthy controls. High-resolution structural brainstem scans were carried out using magnetic resonance imaging (MRI), data analyzed voxel-based morphometry approach. The...
Abstract Objective To determine whether low dosages (4.5 mg/day) of naltrexone reduce fibromyalgia severity as compared with the nonspecific effects placebo. In this replication and extension study a previous clinical trial, we tested impact low‐dose on daily self‐reported pain. Secondary outcomes included general satisfaction life, positive mood, sleep quality, fatigue. Methods Thirty‐one women participated in randomized, double‐blind, placebo‐controlled, counterbalanced, crossover study....
Determinants of the duration opioid use after surgery have not been reported. We hypothesized that both preoperative psychological distress and substance abuse would predict more prolonged surgery.Between January 2007 April 2009, a prospective, longitudinal inception cohort study enrolled 109 134 consecutively approached patients undergoing mastectomy, lumpectomy, thoracotomy, total knee replacement, or hip replacement. measured use, then daily opioids until reported cessation consumption...
Background A patient’s response to treatment may be influenced by the expectations that patient has before initiating treatment. In context of clinical trials, influence participant expectancy blur distinction between real and sham treatments, reducing statistical power detect specific effects. There is therefore a need for tool prospectively predicts effects on outcomes across wide range modalities. Purpose To help assess effects, we created Stanford Expectations Treatment Scale (SETS): an...
Fibromyalgia (FM) is a complex, multi-symptom condition that predominantly affects women. The majority of those affected are unlikely to gain significant symptomatic control from the few treatments approved for FM. In this 10-week, single-blind, crossover trial we tested immune effects eight weeks oral administration low-dose naltrexone (LDN). We enrolled women with an average age 46 years, symptom severity 62 out 100, and duration 14 years. found LDN was associated reduced plasma...
Many conceptualizations of forgiveness currently exist in the literature. The present study adds another perspective to discussion by investigating lay definitions forgiveness, as well reasons for and nonforgiveness. In Study 1, undergraduate students completed a questionnaire packet which they provided three narratives interpersonal offense: time when had been hurt then forgave offender, did not forgive, someone else were forgiven. Respondents also asked questions about their...
Abstract Background Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent that not alleviated rest. The lack of clearly identified underlying mechanism has hindered the development effective treatments. Studies have demonstrated elevated levels inflammatory factors in patients with CFS, but findings are contradictory across studies and no biomarkers been consistently supported. Single time-point approaches potentially overlook important features such as...
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for provided venous samples reported their pain severity over 25 consecutive days. All exhibited normal menstrual cycles were not taking oral contraceptives. Cortisol, the estradiol, progesterone, testosterone, assayed from serum. A linear mixed model used determine if fluctuations associated with changes in severity. In...
The role of attachment style in relation to forgiveness was investigated 2 betrayal interviews. Blood pressure and heart rate were assessed, along with style, forgiveness, empathy, emotional expressiveness. Securely attached individuals more forgiving the specific offense, had higher levels trait expressed positive emotion. adults lower interview systolic blood exhibited greater recovery. Attachment may be an independent antecedent forgiveness.
In the management of clinical low back pain (LBP), actual damage to lower areas such as muscles, intervertebral discs etc. are normally targeted for therapy. However, LBP may involve not only sensory pain, but also underlying affective which play an important role overall in painful events. Therefore we hypothesized that visualization a event trigger memories, thus provoking dimension pain. The present study investigated neural correlates affect processing subjects with (n = 11) and without...
Gulf War Illness (GWI) is a clinically heterogeneous chronic condition that affects many veterans of the 1990–1991 Persian War. One most prevalent and debilitating symptoms GWI abnormal fatigue. The mechanisms underlying generally, fatigue specifically, have yet to be conclusively identified, although immune system abnormalities are suspected involved. first goal this monitoring study was determine if associated with higher absolute levels daily variability pro-inflammatory factors. second...
Leptin, an appetite-regulatory hormone, is also known to act as a proinflammatory adipokine. One of the effects increased systemic leptin concentrations may be greater sensitivity pain. We report results two studies examining association between and pain: small pilot longitudinal study, followed by large cross-sectional study. In Study 1, three women with physician-diagnosed fibromyalgia provided blood draws daily for 25 consecutive days, well self-reported musculoskeletal Daily fluctuations...