A5037070614- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Rate Variability and Autonomic Control
- Diabetes and associated disorders
- Body Composition Measurement Techniques
- Cardiovascular and exercise physiology
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Renal function and acid-base balance
University of Bern
2006-2024
University Hospital of Bern
2022-2024
University of Lausanne
2013-2022
Hôpital intercantonal de la Broye
2015-2019
Centre Hospitalier Universitaire de Liège
2018
Temple University Hospital
2018
University Hospital of Lausanne
2006-2016
Association on Higher Education And Disability
2016
Hôpital Orthopédique de la Suisse Romande
2011-2012
Czech Academy of Sciences, Institute of Physiology
1993-2011
BACKGROUND Obesity is associated with an increased incidence of cardiovascular complications, but the underlying mechanism unknown. In experimental animals, overfeeding sympathetic activation, and there evidence that adrenergic mechanisms contribute to complications. METHODS AND RESULTS We recorded resting postganglionic nerve discharge (using intraneural microelectrodes) skeletal muscle blood vessels in 37 healthy subjects covering a broad spectrum percent body fat. To assess potential...
High-fructose diet stimulates hepatic de novo lipogenesis (DNL) and causes hypertriglyceridemia insulin resistance in rodents. Fructose-induced may be secondary to alterations of lipid metabolism. In contrast, fish oil supplementation decreases triglycerides improve resistance. Therefore, we studied the effect high-fructose on DNL VLDL their impact Seven normal men were four occasions: after (7.2 g/day) for 28 days; a 6-day (corresponding an extra 25% total calories); plus diet; control...
•It is debated whether fructose drives the metabolic syndrome or non-alcoholic fatty liver disease.•Fructose in a liquid form, within sugar-sweetened beverages, may impact metabolism.•Herein, consumption of beverages containing sucrose increased hepatic lipogenesis.•Increased lipogenic activity promote long-term perturbations. Background & aimsExcessive intake associated with de novo lipogenesis, blood triglycerides, and insulin resistance. We aimed to determine elicits specific effects on...
EFSA JournalVolume 20, Issue 2 e07074 Scientific OpinionOpen Access Tolerable upper intake level for dietary sugars Panel on Nutrition, Novel Foods and Food Allergens (NDA), Corresponding Author (NDA) nda@efsa.europa.eu Correspondence:nda@efsa.europa.euSearch more papers by this authorDominique Turck, Dominique TurckSearch authorTorsten Bohn, Torsten BohnSearch authorJacqueline Castenmiller, Jacqueline CastenmillerSearch authorStefaan de Henauw, Stefaan HenauwSearch authorKaren Ildico...
Euglycemic hyperinsulinemia evokes both sympathetic activation and vasodilation in skeletal muscle, but the mechanism remains unknown. To determine whether insulin per se or insulin-induced stimulation of carbohydrate metabolism is main excitatory stimulus, we performed, six healthy lean subjects, simultaneous microneurographic recordings muscle nerve activity, plethysmographic measurements calf blood flow, calorimetric determinations oxidation rate. Measurements were made during 2 h of: (a)...
The sympathetic nervous system is an important regulatory mechanism of both metabolic and cardiovascular function, altered activity may play a role in the etiology and/or complications obesity. In lean subjects, insulin evokes activation vasodilation skeletal muscle. obese subjects such impaired and, turn, contribute to resistance. To examine relationship between vasodilatory responses muscle hyperinsulinemia, we simultaneously measured nerve (MSNA) calf blood flow at basal during 2-h...
Objective: To evaluate the relative importance of increased lactate production as opposed to decreased utilization in hyperlactatemic patients, well their relation glucose metabolism. Design: Prospective observational study. Setting: Surgical intensive care unit a university hospital. Patients: Seven patients with severe sepsis or septic shock, seven cardiogenic and healthy volunteers. Interventions: 13C-labeled sodium was infused at 10 μmol/kg/min then 20 over 120 mins each. 2H-labeled...
To determine whether increasing doses (amounts) of beta-glucan present in an extruded breakfast cereal affect the glycemic and insulinemic responses eight NIDDM subjects, compared with same after a continental (bread, milk, cheese, ham).Breakfast cereals were produced using various proportions oat bran enriched fiber, which contain unusually high amount viscous polysaccharide, called beta-glucan, bran. The carbohydrate load was 35 g.The maximum increases observed plasma glucose 67% (P <...
Bariatric surgery markedly improves glucose homeostasis in patients with type 2 diabetes even before any significant weight loss is achieved. Procedures that involve bypassing the proximal small bowel, such as Roux-en-Y gastric bypass (RYGBP), are more efficient than restriction procedures banding (GB).To evaluate effects of RYGBP and GB on postprandial kinetics gastro-intestinal hormone secretion after an oral load.This study was a cross-sectional comparison among non-diabetic,...
Objective To compare the effects of isocaloric, isonitrogenous carbohydrate nutrition vs. lipid-based total parenteral on respiratory gas exchange and intermediary metabolism in critically ill patients. Design Prospective, clinical trial. Setting Surgical intensive care unit a major university hospital Switzerland. Patients Sixteen patients admitted to surgical unit. Interventions were randomized receive isocaloric (TPN) containing 75% (TPN-glucose) or 15% (TPN-lipid) glucose over 5-day...
Adverse effects of hypercaloric, high-fructose diets on insulin sensitivity and lipids in human subjects have been shown repeatedly. The implications fructose amounts close to usual daily consumption, however, not well studied. This study assessed the effect moderate sucrose compared with glucose lipid metabolism.Nine healthy, normal-weight male volunteers (aged 21-25 years) were studied this double-blind, randomized, cross-over trial. All consumed four different sweetened beverages (600...
The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken up by peripheral tissues, mainly heart, skeletal muscle, adipose tissue. Blocking hepatic VLDL secretion interferes with delivery of liver-derived to tissues results an accumulation liver. However, it is unclear how interfering triglyceride affects adiposity, muscle stores, insulin sensitivity. To explore issues, we examined mice that cannot secrete [due absence microsomal transfer protein (Mttp)...