A5059746143- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Education
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- SARS-CoV-2 and COVID-19 Research
- Neuroblastoma Research and Treatments
- Ion Transport and Channel Regulation
- Pharmacology and Obesity Treatment
- Hormonal and reproductive studies
- Birth, Development, and Health
- Neuroendocrine Tumor Research Advances
- Lipoproteins and Cardiovascular Health
- Orthopedic Infections and Treatments
- Poisoning and overdose treatments
Johns Hopkins Medicine
2016-2025
Suburban Hospital
2016-2025
Johns Hopkins University
2016-2025
Johns Hopkins Hospital
2024
William Carey University
2019-2022
Howard County General Hospital
2022
University of Maryland, Baltimore
2022
National Institutes of Health
2012-2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2021
Saint Agnes Hospital
2009
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
Inactivating germline mutations of the probable tumor suppressor gene, armadillo repeat containing 5 (ARMC5), have recently been identified as a genetic cause macronodular adrenal hyperplasia (MAH).We searched for ARMC5 in large cohort patients with MAH. The clinical phenotype and without was compared.Blood DNA from 34 MAH genotyped using Sanger sequencing. Diurnal serum cortisol measurements, plasma ACTH levels, urinary steroids, 6-day Liddle's test, computed tomography, weight glands at...
Primary aldosteronism is one of the leading causes secondary hypertension, causing significant morbidity and mortality. A number genetic defects have recently been identified in primary aldosteronism, whereas we mutations ARMC5, a tumor-suppressor gene, cortisol-producing macronodular adrenal hyperplasia.We investigated cohort 56 patients who were referred to National Institutes Health for evaluation ARMC5 defects.Patients underwent step-wise diagnosis, with measurement serum aldosterone...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
Clinical interpretation of continuous glucose monitoring (CGM) data for people without diabetes has not been well established. This study aimed to investigate concordance among CGM experts in recommending clinical follow-up individuals diabetes, based upon their independent review data. We sent a survey out expert clinicians (n = 18) and asked them evaluate 20 potentially challenging Dexcom G6 Pro reports (and hemoglobin A1c [HbA1c] fasting venous blood levels) from diabetes. Clinicians...
<h3>Importance</h3> Accurate clinical decision support tools are needed to identify patients at risk for iatrogenic hypoglycemia, a potentially serious adverse event, throughout hospitalization. <h3>Objective</h3> To predict the of hypoglycemia within 24 hours after each blood glucose (BG) measurement during hospitalization using machine learning model. <h3>Design, Setting, and Participants</h3> This retrospective cohort study, conducted 5 hospitals Johns Hopkins Health System, included 54...
Primary macronodular adrenal hyperplasia (PMAH) is a rare type of Cushing's syndrome (CS) that results in increased cortisol production and bilateral enlargement the glands. Recent work showed disease may be caused by germline somatic mutations ARMC5 gene, likely tumor suppressor gene (TSG). We investigated 20 different nodules from one patient with PMAH for sequence changes.All were obtained single who underwent adrenalectomy. DNA was extracted standard protocol determined Sanger...
Familial hyperaldosteronism type III (FH-III) is a rare and clinically heterogeneous condition, that can display mild as well severe phenotypes. Point mutations in the KCNJ5 gene, affecting ion selectivity of inward rectifier K(+) channel 4 (Kir3.4), underlie molecular basis FH-III.The objective study was to investigate effects de novo germline mutation.We describe case girl who came medical attention at age 2 years because polydipsia, polyuria, failure thrive. The patient, affected by...
Background: Hospitalized patients with diabetes are at risk of complications and longer length stay (LOS). Inpatient Diabetes Management Services (IDMS) known to be beneficial; however, their impact on patient care measures in community, non-teaching hospitals, is unknown. Objectives: To evaluate whether co-managing by the IDMS team reduces LOS 30-day readmission rate (30DR). Methods: This retrospective quality improvement cohort study analyzed 30DR among admitted a community hospital. The...
The optimal diet to improve glycemia in patients with type 2 diabetes remains unclear. Low carbohydrate, high fat (LCHF) diets can glycemic control, but have not been investigated real-world settings.
Diabetes mellitus, a looming crisis, is approaching worldwide epidemic proportions. In 2018, 34.2 million Americans, or 10.5% of the population had diabetes. Climate change, and in particular rising global temperatures, may exacerbate various health issues, including diabetes ultimately lead to increased mortality.To identify impact climate change on diabetes.A systematic literature review Pubmed (MEDLINE database references abstracts life sciences biomedical topics from USA National Library...
The diagnosis and management of hypercalcemia in hospitalized patients can be challenging. Hypercalcemia is often associated with significant morbidity end-organ damage which may delay a patient's recovery. We report case series three who underwent orthopedic procedures intraoperative placement vancomycin-loaded calcium sulfate beads. Patients had no known history malignancy or excess intake calcium, vitamin A D. Laboratory workup showed low parathyroid (PTH) levels normal PTH-related...
Abstract BACKGROUND Somatic variants in KCNJ5 are the most common cause of primary aldosteronism (PA). There few patients with PA whom disease is caused by germline potassium channel gene (familial hyperaldosteronism type III—FH-III). METHODS A 5-year-old patient who developed hypertension due to bilateral adrenocortical hyperplasia (BAH) causing had negative peripheral DNA testing for any known genetic causes PA. He was treated medically adequate control his but third decade life, worsening...