A5039354063- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Management and Research
- Diabetes Management and Education
- Diabetic Foot Ulcer Assessment and Management
- Gastrointestinal motility and disorders
- Chronic Disease Management Strategies
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Clinical practice guidelines implementation
- Skin Diseases and Diabetes
- Telemedicine and Telehealth Implementation
- Advanced Neuroimaging Techniques and Applications
- Pancreatic function and diabetes
- Advancements in Transdermal Drug Delivery
- Metabolism, Diabetes, and Cancer
- Mental Health and Patient Involvement
Steno Diabetes Centers
2020-2025
Aalborg University Hospital
2017-2025
Aalborg University
2019-2025
Steno Diabetes Center North Jutland
2019-2023
Sjællands Universitetshospital, Nykøbing F.
2020-2021
Endocrinology Research Center
2021
University of California, San Francisco
2021
Aalborg Portland (Denmark)
2020
Research Network (United States)
2020
Aarhus University Hospital
2008-2019
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
Summary Background TZP‐101 is a synthetic, selective ghrelin agonist in development for gastroparesis. Aim To assess safety and effects of diabetes patients with symptomatic Methods Adults type 1 or 2 mellitus received placebo (80, 160, 320 600 μg/kg) infusions cross‐over manner following radiolabelled meal. Blood glucose levels were stabilized using hyperinsulinemic‐euglycemic clamp. Primary endpoints gastric half emptying latency times. Secondary measures included assessment gastroparesis...
Background Gastroparesis, a chronic disorder of abnormal gastric motility, is common in patients with diabetes mellitus. A synthetic, selective ghrelin receptor agonist, TZP-101, clinical development for treatment gastroparesis. This double-blind, randomized, placebo-controlled study evaluated the safety and efficacy multiple TZP-101 doses moderate to severe symptomatic diabetic Methods Patients were admitted hospital adaptively randomized receive single 30-min intravenous infusion 20, 40,...
There is limited evidence on how intensive multifactorial treatment (IT) improves outcomes of diabetes when initiated in the lead time between detection by screening and diagnosis routine clinical practice. We examined effects early IT type 2 primary care prevalence diabetic peripheral neuropathy (DPN) arterial disease (PAD) 6 years later a pragmatic, cluster-randomized parallel group trial.A stepwise program 190 general practices Denmark was used to identify 1,533 people with diabetes....
Abstract Background TZP ‐102, a potent, oral, ghrelin receptor agonist, improved diabetic gastroparesis symptoms in Phase 2a. Methods Patients with type 1 or 2 diabetes, delayed gastric half‐emptying (T 1/2 ), and ≥3 months randomized : to double‐blind placebo, 10‐mg, 20‐mg ‐102 once daily for 12 weeks (Study ‐102‐ CL ‐G003). Study ‐G004 patients 10‐mg ‐102:placebo three‐times‐daily. Primary endpoint was change‐from‐baseline through Weeks 11–12 Daily Diary of Gastroparesis Symptoms...
Abstract Background Gastroparesis causes significant morbidity and treatment options are limited. TZP‐102 a novel, macrocyclic, selective, oral ghrelin receptor agonist, was evaluated in randomized, double‐blind, placebo‐controlled trial patients with diabetic gastroparesis. Methods A total of 92 outpatients were randomized to once‐daily administrations 10‐mg ( n = 22), 20‐mg 21), 40‐mg 23) or placebo 26). The primary endpoint the change from baseline gastric half‐emptying time T ½ )...
Summary Aims Observations are made on four Type 1 diabetic patients with the rare syndrome of intractable vomiting from confirmed gastroparesis, to determine whether radical surgery would alleviate their symptoms and subsequently examine in detail gastric histopathology. Methods The surgical approach consisted an ≈ 70% resection stomach, including antrum pylorus, closure duodenum restoration gastrointestinal continuity a 60‐cm Roux‐en‐Y jejunal loop. Four longstanding were examined treated...
Aliment Pharmacol Ther 2011; 33: 679–688 Summary Background Limited therapeutic options exist for severe gastroparesis, where nausea and vomiting can lead to weight loss, dehydration malnutrition due inadequate caloric fluid intake. TZP-101 (ulimorelin) is a ghrelin receptor agonist that accelerates gastric emptying improves upper gastrointestinal symptoms in diabetic patients with gastroparesis. Aim To assess effects of gastroparesis nausea/vomiting baseline severity scores ≥3.5 (range:...
This study evaluates whether diffusion tensor imaging magnetic resonance neurography (DTI-MRN), T2 relaxation time, and proton spin density can detect grade neuropathic abnormalities in patients with type 1 diabetes. Patients diabetes (n = 49) were included—11 severe polyneuropathy (sDPN), 13 mild (mDPN), 25 without (nDPN)—along 30 healthy control subjects (HCs). Clinical examinations, nerve conduction studies, vibratory perception thresholds determined the presence severity of DPN. DTI-MRN...
Abstract Aims To evaluate physical activity in people with newly diagnosed Type 2 diabetes using objective measures. Methods We analysed data from a study aimed at assessing carotid femoral pulse wave velocity which piezoelectric accelerometer was worn by 100 and age‐ sex‐matched control subjects. Differences patterns were investigated. Results Compared the group, spent significantly more time engaged sedentary or lower level activities during day, mean ( sd ) of 926 (44) vs 898 (70) min, P...
To evaluate if diffusion tensor imaging MR neurography (DTI-MRN) can detect lesions of peripheral nerves in patients with type 1 diabetes.Eleven diabetic polyneuropathy (DPN), 10 without (nDPN), and healthy controls (HC) were investigated a 3T MRI scanner. Clinical examinations, nerve-conduction studies, vibratory-perception thresholds determined the presence DPN. DTI-MRN (voxel size: 1.4 × 3 mm3 ; b-values: 0, 800 s/mm2 ) covered proximal (sciatic nerve) distal regions lower extremity...
OBJECTIVE—This study examines whether autonomic nerve autoantibodies (ANabs) are associated with development of neuropathy using a prospective design. RESEARCH DESIGN AND METHODS—A group type 1 diabetic patients were followed prospectively regard to function on four occasions. At the third examination, 41 tested for ANabs (complement-fixing sympathetic ganglion, vagus nerve, and adrenal medulla), results related cardiac (heart rate variation during deep breathing [expiration/inspiration...
The pathogenesis of gastrointestinal symptoms in diabetes mellitus is complex and multi-factorial. Diabetes induced peripheral central changes the neuronal pain matrix may be importance were explored using a new multi-modal multi-segmental sensory testing approach. sensitivity to mechanical, thermal electrical stimulations oesophagus duodenum was assessed 12 type-1 diabetic patients with proven autonomic neuropathy severe comprehensive stimulation device aiming activate different gut nerves...
In this study we aimed to investigate the functional connectivity of brain regions involved in sensory processing diabetes with and without painful painless diabetic peripheral neuropathy (DPN) association nerve function pain intensity.In cross-sectional used resting-state MRI (fMRI) 19 individuals type 1 DPN, 18 20 healthy control subjects. Seed-based analyses were performed for thalamus, postcentral gyrus, insula, z scores correlated measurements scores.Overall, compared those DPN...
Abstract Introduction Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the current evidence not well described. This study investigated function adults type 1 diabetes mellitus (T1DM) association to painful/painless DPN clinical parameters. Methods cross‐sectional, observational, case–control included 58 participants T1DM, sub‐grouped into 20 T1DM DPN, 19 without healthy controls were...
<p dir="ltr">Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful painless DPN QoL, socioeconomic factors, 2) assess prevalence sensory descriptors, 3) evaluate association descriptors above factors.</p><p dir="ltr">Research Design Methods: Participants were grouped into people with (n=1,601) without (n=5,359)...
<p dir="ltr">Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful painless DPN QoL, socioeconomic factors, 2) assess prevalence sensory descriptors, 3) evaluate association descriptors above factors.</p><p dir="ltr">Research Design Methods: Participants were grouped into people with (n=1,601) without (n=5,359)...