A5105762001- Neuroscience and Neuropharmacology Research
- Hepatitis B Virus Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Heat shock proteins research
- Mitochondrial Function and Pathology
- Growth Hormone and Insulin-like Growth Factors
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis C virus research
- Neurological disorders and treatments
- Genetic Syndromes and Imprinting
- Electrochemical sensors and biosensors
- Mycobacterium research and diagnosis
- Neuroscience and Neural Engineering
- FinTech, Crowdfunding, Digital Finance
- Molecular Junctions and Nanostructures
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Thermoregulation and physiological responses
- Anesthesia and Neurotoxicity Research
- Medical and Biological Sciences
- Nutrition and Health Studies
- Analytical Chemistry and Sensors
Indiana University School of Medicine
2017
Indiana University – Purdue University Indianapolis
2013-2017
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017
University of Tennessee Health Science Center
2000-2016
St. John's Hospital
2010
Helios Klinikum Krefeld
2009
Saint Vincent Hospital
2006-2008
Central Indiana Gastroenterology Group
2008
Kumamoto University
2000
University of Cambridge
1997
This consensus statement from the members of American Neurogastroenterology and Motility Society Nuclear Medicine recommends a standardized method for measuring gastric emptying (GE) by scintigraphy. A low-fat, egg-white meal with imaging at 0, 1, 2, 4 h after ingestion, as described published multicenter protocol, provides information about normal delayed GE. Adoption this protocol will resolve lack uniformity testing, add reliability credibility to results, improve clinical utility GE test.
Abstract Background Gastric electrical stimulation ( GES ) is a therapeutic option for intractable symptoms of gastroparesis GP ). Idiopathic ID ‐ represents subset . AIMS : A prospective, multicenter, double‐blinded, randomized, crossover study to evaluate the safety and efficacy Enterra in treatment chronic vomiting Methods Thirty‐two subjects (mean age 39; 81% F, mean 7.7 years were implanted with The stimulator was turned ON 1½ months followed by double‐blind randomization consecutive...
Capsule endoscopy reading is time consuming, and readers are required to maintain attention so as not miss significant findings. Deep convolutional neural networks can recognise relevant findings, possibly exceeding human performances reducing the of capsule endoscopy. Our primary aim was assess non-inferiority artificial intelligence (AI)-assisted versus standard for potentially small bowel bleeding lesions (high P2, moderate P1; Saurin classification) at per-patient analysis. The mean in...
Background Gastroparesis, a chronic disorder of abnormal gastric motility, is common in patients with diabetes mellitus. A synthetic, selective ghrelin receptor agonist, TZP-101, clinical development for treatment gastroparesis. This double-blind, randomized, placebo-controlled study evaluated the safety and efficacy multiple TZP-101 doses moderate to severe symptomatic diabetic Methods Patients were admitted hospital adaptively randomized receive single 30-min intravenous infusion 20, 40,...
To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy (OC) and assess diagnostic yield.This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy (CCE) following OC performed an experienced gastroenterologist (> 1000 colonoscopies). Patients with stenosis were excluded. According patient preferences, CCE was day (protocol A) after staying on clear liquids 0.75 L...
The molecular changes that occur in the stomach are associated with idiopathic gastroparesis poorly described. aim of this study was to use quantitative analysis mRNA expression identify mRNAs encoding proteins required for normal motility functions stomach.Full-thickness biopsy samples were collected from non-diabetic control subjects who exhibited no symptoms and patients gastroparesis. isolated muscularis externa levels determined by reverse transcriptase (RT)-PCR.Smooth muscle tissue had...
Peptides derived from each of the 3 endogenous opioid precursors were measured in gerbil brain regions at various times after transient bilateral carotid artery occlusion using radioimmunoassays specific for beta-endorphin-, met-enkephalin-, and dynorphin A-related peptides. Lasting changes observed only hippocampus. The most striking effect was on A immunoreactivity, which reduced by 30-40% as early 1 hour recirculation remained 50% control level least week. In some experiments levels...
BACKGROUND: The viral safety of human plasma products is based on the careful selection donors and donations removal inactivation pathogenic viruses that could potentially contaminate plasma. For analysis final for potential virus contamination, use polymerase chain reaction (PCR) has been proposed. To test whether this method can discriminate between infectious inactivated viruses, following studies were performed. STUDY DESIGN AND METHODS: Infectious virus‐inactivated preparations titrated...
Idiopathic Parkinson’s disease and dopaminergic medication may influence pituitary hormone secretion. The present study aimed to reveal any abnormalities of the somatotrophic system induced by itself and/or therapy. Investigations other hormones under basal stimulated conditions, as well an analysis body composition, were also performed. This was a controlled diagnostic in which luteinising hormone‐releasing hormone, thyroid‐releasing corticotrophin‐releasing arginine hydrochloride...
Summary objective Patients with childhood‐onset GH deficiency (coGHD) need retesting in late adolescence or young adulthood to verify whether they continue treatment. For this purpose the Growth Hormone Research Society (GRS) recommends insulin tolerance test (ITT), as an alternative arginine + growth hormone releasing (ARG GHRH test) a diagnostic tool adolescents and adults. However, there are no standardized cut‐off levels based on normal secretion for determining GHD vs. sufficiency...
Abstract— l ‐DOPA or d ‐amphetamine administration disaggregates brain polyribosomes in animals maintained an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient 40–44° C) does not cause similar disaggregation polysomes. Hence, role drug‐induced is permissive.
Abstract HeLa S3 cells in suspension culture are resynchronized each successive generation by exposure to 0.25m M thymidine. The resynchronization approach appears be superior single‐ and double‐block techniques because the period of effective inhibition DNA synthesis is significantly shortened. Gram quantities highly synchronous viable have been produced on a daily basis.
Chimpanzees were inoculated intravenously with the H strain of hepatitis C virus (HCV), and analysed for viraemia using polymerase chain reaction a humoral immune response first second generation anti-HCV ELISAs an immunoblot assay (4-RIBA). In all seven chimpanzees studied, occurred several weeks before significant increase in serum alanine transferase (ALT) activity, whereas circulating antibodies became detectable at time ALT levels, provided ELISA or 4-RIBA was used. On basis duration...
Abdominal obesity and insulin resistance are central findings in metabolic syndrome. Since treatment with recombinant human growth hormone (rhGH) can reduce body fat mass patients organic GH deficiency, rhGH therapy may also have favourable effects on However, due to the highly increased risk for type 2 diabetes these patients, strategies needed antagonistic effect of against insulin. We conducted a 18-month randomised, double-blind, placebo-controlled study assess combination metformin...
Aims Colonoscopy is considered the gold standard for colorectal cancer screening but lesions can be missed, resulting in interval cancers a significant number of patients. Polyps hidden behind haustral folds or tight flexures are particularly difficult to visualize with current forward-viewing instruments. This prospective study evaluated lesion detection rate and performance novel colonoscope 230-degree (partially retrograde) extra-wide field view compared 170-degree colon model.
Abstract Background and study aims Colonoscopy, the gold standard for early detection of colorectal cancer, may miss polyps especially those hidden behind folds. This prospective compared polyp performance a novel colonoscope with extra-wide field view (EFOV) 230 degrees (partially retrograde) to (SC, 170 degrees) in colon model. Patients methods A 3D printed model was used featuring 12 placed throughout different segments, several located on proximal side haustral Endoscopists were...