A5087624819- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Obstructive Sleep Apnea Research
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Hemodynamic Monitoring and Therapy
- Diabetes and associated disorders
- Cardiac Imaging and Diagnostics
- Renal function and acid-base balance
- MRI in cancer diagnosis
- Non-Invasive Vital Sign Monitoring
- Atherosclerosis and Cardiovascular Diseases
- Retinal Imaging and Analysis
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
- Systemic Lupus Erythematosus Research
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Aarhus University Hospital
2016-2025
Steno Diabetes Centers
2021-2025
Regionshospitalet Silkeborg
2023-2025
Aarhus University
2011-2023
Regional Hospital Horsens
2018-2023
Danish Diabetes Academy
2013-2019
Odense University Hospital
2015-2019
Sygehus Sønderjylland
2016
Lillebaelt Hospital
2016
Hospital South West Jutland
2016
BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but underlying mechanism remains poorly understood. METHODS: To gain insights on primary effects of SGLT2i that are not confounded by pathophysiologic processes or secondary to improvement SGLT2i, we performed an in-depth proteomics, phosphoproteomics, metabolomics analysis integrating signatures from multiple metabolic organs body fluids after 1 week treatment nondiabetic as well...
Abstract Aim Despite the increasing use of combination treatment with sodium‐glucose cotransporter 2 inhibitors and glucagon‐like peptide‐1 receptor agonists, data are limited on effects markers cardiovascular disease. This study aimed to investigate effect empagliflozin, semaglutide, their vascular function. Materials Methods In total, 120 patients type diabetes were randomized into four groups (n = 30 in each) for 32 weeks: placebo, combination. The had two co‐primary outcomes: change...
Objective: This study aims to investigate the continuum of glucose control from normoglycemia dysglycemia (HbA1c ≥ 5.7% / 39 mmol/mol) using metrics derived Continuous Glucose Monitoring (CGM). Additionally, we aim develop a machine learning-based classification model classify based on observed patterns. Methods: Data five distinct studies, each featuring at least two days CGM, were pooled. Participants included individuals classified as healthy, with prediabetes, or type 2 diabetes mellitus...
Background Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality cardiovascular risk. However, the prognostic potential ePWV during long‐term follow‐up in patients with symptoms stable angina remains unknown. Methods Results In this study, was 25 066 without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean 63.7±10.5 years, 58% male) pectoris undergoing elective...
Patients with type 2 diabetes have a high incidence of cardiovascular events including stroke. Increased arterial stiffness (AS) predicts in the general population. Cerebral white matter lesions (WMLs) are associated an increased risk It is unknown whether AS patients WMLs.We examined 89 recently diagnosed (<5 years) and sex- age-matched controls. was assessed carotid-femoral pulse wave velocity (PWV). WMLs were identified using magnetic resonance imaging graded qualitatively Breteler scale...
Abstract Aims To evaluate physical activity in people with newly diagnosed Type 2 diabetes using objective measures. Methods We analysed data from a study aimed at assessing carotid femoral pulse wave velocity which piezoelectric accelerometer was worn by 100 and age‐ sex‐matched control subjects. Differences patterns were investigated. Results Compared the group, spent significantly more time engaged sedentary or lower level activities during day, mean ( sd ) of 926 (44) vs 898 (70) min, P...
The SphygmoCor is used for noninvasive assessment of ascending aortic blood pressure (BP). However, the validity transfer function has not been tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and diastolic (DBP) brachial BP previously associated substantial imprecision central estimates. We hypothesized that different calibration strategies might improve accuracy estimated BPs.In 34 patients diabetes we SBP DBP using device compared these data...
Central blood pressure (BP) can be assessed noninvasively based on radial tonometry and may potentially a better predictor of clinical outcome than brachial BP. However, the validity obtained estimates has never been examined in patients with chronic kidney disease (CKD). Here we compared invasive aortic systolic BP (SBP) estimated central SBP by artery influence renal function arterial stiffness this relationship. We evaluated 83 stage 3 to 5 CKD (mean glomerular filtration rate [eGFR] 30...
Blood pressure (BP) is a leading global risk factor. Increasing age related to changes in cardiovascular physiology that could influence cuff BP measurement, but this has never been examined systematically and was the aim of study. Cuff compared with invasive aortic across decades (from 40 89 years) using individual-level data from 31 studies (1674 patients undergoing coronary angiography) 22 different devices (19 oscillometric, 1 automated auscultation, 2 mercury sphygmomanometry) Invasive...
Accurate blood pressure (BP) measurement is critical for optimal cardiovascular risk management. Age-related trajectories cuff-measured BP accelerate faster in women compared with men, but whether cuff represents the intraarterial (invasive) aortic unknown. This study aimed to determine sex differences between BP, invasive and difference 2 measurements. Upper-arm were measured during coronary angiography 1615 subjects from Invasive Blood Pressure Consortium Database. analysis comprised 22...
To evaluate the effect of treatment with semaglutide and empagliflozin on cortico-medullary sodium gradient (MCR; medulla/cortex ratio), urine sodium/creatinine ratio (UNACR), estimated plasma volume (ePV) to compare MCR between persons without type 2 diabetes.
Type 2 diabetes (T2D) is related to an increased fracture risk and low bone turnover. However, the mechanisms are not elucidated. In present study we investigate association between glycemic variability turnover markers.100 participants with T2D 100 age gender matched controls were included in this cross-sectional study. All equipped a continuous glucose monitoring (CGM) sensor for 3 days (CGMS iPro Continuous Glucose Recorder; Medtronic MiniMed). The dawn levels defined as morning period...
Abstract Aims The anti-inflammatory drug colchicine has been shown to reduce the risk of cardiovascular disease in patients with and without diabetes. underlying mechanisms are, however, elusive. In this trial, we investigated effect on arterial stiffness, ambulatory blood pressure, albuminuria type 2 Methods We conducted a double-blind, randomized, placebo-controlled trial individuals diabetes history or high hereof. One hundred participants were assigned 1:1 ratio receive 0.5 mg once daily...
Recently developed dynamic whole-body PET/CT (D-WB PET/CT) protocols allow for measurements of potentially more precise metabolic parameters than the commonly used semiquantitative SUV. Most notable is rate FDG uptake (MRFDG), which reflects quantitative glucose into tissues and organs. However, data on reproducibility MRFDG are scarce, particularly in patients with perturbed homeostasis such as type 2 diabetes. We therefore aimed to evaluate test-retest repeatability both SUV these...
Central blood pressure (BP) has attracted increasing interest because of a potential superiority over brachial BP in predicting cardiovascular morbidity and mortality. Several devices estimating central noninvasively are now available. The aim our study was to determine the validity Arteriograph, cuff-based, oscillometric device, patients with type 2 diabetes. We measured invasively compared it Arteriograph-estimated values 22 diabetic referred elective coronary angiography. difference...
OBJECTIVE To investigate the sex differences in cardiac autonomic modulation patients with newly diagnosed type 2 diabetes and to determine whether is associated glycemic variability. RESEARCH DESIGN AND METHODS We investigated a cohort consisting of 48 men 39 women non-insulin-treated known duration &lt;5 years. All were equipped continuous glucose monitoring sensor for 3 days, mean amplitude excursions (MAGE) was calculated obtain individual Cardiac quantified by analysis heart rate...
Perturbations in the insulin-like growth factor (IGF) system may contribute to accelerated cardiovascular disease (CVD) that occurs patients with type 2 diabetes (T2D). However, it remains unknown whether IGF is also involved development of early, subclinical CVD. We characterised T2D and matched controls examined associations markers target organ damage.The study included 99 recently diagnosed age- sex-matched controls. IGF-1 IGFBP-1 -4 were measured by immunoassays, as pregnancy-associated...
Women with Turner Syndrome have an increased risk for aortic dissection. Arterial stiffening is a factor dilatation and Here we investigate if arterial can be observed in patients initial step the development of subsequent Fifty-seven women (48 years [29–66]) thirty-six age- sex-matched controls (49 [26–68]) were included. Distensibility, blood pressure, carotid-femoral pulse wave velocity (PWV), augmentation index (Aix) central pressure determined using cardiovascular magnetic resonance,...
The pathophysiological perturbations underlying the unfavorable cardiovascular prognosis in women with type 2 diabetes (T2DM) remain elusive. Low subendocardial viability ratio (SEVR), an index of myocardial oxygen supply and demand, has been associated intermediate risk markers mortality various populations. However, whether SEVR is sex patients T2DM remains to be clarified. We examined 86 (mean age 59±10 years, 47% women, median duration 1.9 (range 0.2–5.0) years) sex- age-matched control...