A5001422466- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Renal function and acid-base balance
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Magnesium in Health and Disease
- Diabetes Treatment and Management
- Potassium and Related Disorders
- Pregnancy and preeclampsia studies
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
- Birth, Development, and Health
- Sodium Intake and Health
- Education, Healthcare and Sociology Research
- Hemodynamic Monitoring and Therapy
- Thermoregulation and physiological responses
- High Altitude and Hypoxia
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
Oslo University Hospital
2020-2025
University of Oslo
2022-2025
Aarhus University Hospital
2014-2025
Aarhus University
2014-2023
Regionshospitalet Viborg
2017
Patients treated with chronic dialysis or kidney transplantation have difficulties in maintaining employment. We aimed to estimate employment rates among and transplant patients from 3 years before after initiating undergoing transplantation. All first-time aged 18–65 Denmark 2005 2019 were identified using the Danish Nephrological Register linked information about social security benefits. Each patient was matched references. In total, 4,469 (median age 55 years, 65% males) 2,294 receiving...
Central blood pressure (BP) can be assessed noninvasively based on radial tonometry and may potentially a better predictor of clinical outcome than brachial BP. However, the validity obtained estimates has never been examined in patients with chronic kidney disease (CKD). Here we compared invasive aortic systolic BP (SBP) estimated central SBP by artery influence renal function arterial stiffness this relationship. We evaluated 83 stage 3 to 5 CKD (mean glomerular filtration rate [eGFR] 30...
Introduction Hypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus. Methods In transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensitivity with the Matsuda index, modified Stumvoll and HOMA-2 IR . First second phase secretion was assessed using equation. Participants were categorized into tertiles by plasma magnesium levels,...
Introduction Women with a history of preeclampsia have increased risk cardiovascular disease later in life. However, it is unclear whether early gestational age at onset associated higher risk. This study aimed to test the association between (including early-onset/late-onset distinction) and subclinical atherosclerosis arterial stiffness age-matched women 12 years after index pregnancy. Material methods Eligible participants were identified two Danish registries. Main outcome measures...
Key Points This study developed a urine acid/base score to assess tubular acid excretion capacity and identify early retention in CKD. The results show that signs of (a low score) are associated with higher risk for CKD progression. Future research should address if can be improved this translates into clinically meaningful effects. Background Acidosis is exacerbated loss kidney function Currently, status assessed by plasma measures, although organ-damaging covert acidosis, subclinical may...
<b><i>Introduction:</i></b> Chronic kidney disease (CKD) is associated with cardiovascular (CVD) and death. Albuminuria an established risk factor, but additional biomarkers predicting CKD progression or CVD are needed. Arterial stiffness easily measurable parameter that has been mortality. We evaluated the ability of carotid-femoral pulse wave velocity (PWV) urine albumin-creatinine (UAC) ratio to predict progression, events, mortality in a cohort patients....
Vascular status following renal transplantation (RT) may improve while living kidney donation (LKD) is possibly associated with an increased cardiovascular risk.We prospectively assessed glomerular filtration rate (mGFR, 51Chrome EDTA clearance) and intermediate vascular risk factors in terms of blood pressure (BP), pulse wave velocity (PWV), central augmentation index (AIx), excess (Pexcess), forearm resistance donors (n = 58, 45 ± 13 years) recipients 51, 50 12 before one year LKD or...
Background. Hyperkalemia is common in kidney transplant (KTx) recipients. Patiromer, a potassium-binding polymer used to treat acute and chronic hyperkalemia, has the potential bind charged particles gastrointestinal tract thereby potentially affect absorption of coadministered drugs. The immunosuppressive drug tacrolimus (Tac) narrow therapeutic window, susceptible drug-drug interactions (DDIs), interaction with patiromer could elevate risk allograft rejection. We aimed investigate DDI...
Established essential hypertension is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for uncertain.Participants from Danish Hypertension Prevention Project (DHyPP) (both parents hypertensive) (n = 95, 41 ± 1 years, 53% men) were compared available spouses 45, years) using measurements ambulatory blood pressure (BP), left ventricular mass index (LVMI), pulse wave velocity, central BP augmentation...
Blood pressure (BP) control is important in chronic kidney disease (CKD), but a reduction brachial BP may not mirror changes central aortic (cBP) during antihypertensive medication. We hypothesize that fall cBP better reflected enhanced vasodilation treatment (EVT) compared with reduced (RVT) because of different hemodynamic actions these interventions.Eighty-one hypertensive CKD stage 3-4 patients (mean measured glomerular filtration rate 36 ml/min per 1.73 m2) were randomized to either EVT...
<b><i>Background:</i></b> Central blood pressure (BP) assessed noninvasively considerably underestimates true invasively measured aortic BP in chronic kidney disease (CKD) patients. The difference between the estimated and increases with decreasing glomerular filtration rates (eGFR). present study investigated whether calcification affects noninvasive estimates of central BP. <b><i>Methods:</i></b> Twenty-four patients CKD stage 4–5 undergoing...
β-cell replacement therapy (βCRT), including pancreas transplantation alone (PTA) and islet (ITX), is a treatment option for selected type 1 diabetes patients. All potential candidates βCRT in Norway are referred to one national transplant centre evaluation before any pre-transplant workup started. This was performed by nephrologist prior 2015 multidisciplinary team (MDT) from 2015. We have reviewed the allocation of patients modality 1-year clinical outcome after transplantation.Medical...
Objective: Living kidney donation (LKD) is possibly associated with an increased cardiovascular risk while on the other hand vascular health following renal transplantation may improve. The objective of our study was to assess alterations in intermediate factors among living donors as well their transplant recipients. Design and method: In a prospective we measured glomerular filtration rate (GFR, 51Chrome EDTA clearance), 24-hour ambulatory blood pressure (BP), pulse wave velocity (PWV,...
Abstract Background and Aims Hypomagnesaemia has been associated with increased insulin resistance decreased secretion. Recent data suggest that early post-engraftment hypomagnesaemia may play a role in development of post-transplant diabetes mellitus (PTDM). This single-centre study investigated the association between 8 weeks glucose metabolism changes 1 year after kidney transplantation. Method The included 425 renal transplantation recipients, transplanted at Oslo University Hospital...
Abstract BACKGROUND AND AIMS Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular (CVD) and death. Albuminuria has been identified as a factor, however, additional biomarkers predicting CKD progression CVD are needed. Arterial stiffness easily measurable candidate that mortality. We compared the ability carotid-femoral pulse wave velocity (PWV) urine albumin-creatinine (UAC) ratios to predict progression, events (myocardial infarction or stroke) mortality in...