A5058865470- Nutrition and Health in Aging
- Frailty in Older Adults
- Magnesium in Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Parathyroid Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Health disparities and outcomes
- Vitamin C and Antioxidants Research
- Bone health and osteoporosis research
- Immunotherapy and Immune Responses
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Heparin-Induced Thrombocytopenia and Thrombosis
- vaccines and immunoinformatics approaches
- Thermal Regulation in Medicine
- Neurological Complications and Syndromes
- Dialysis and Renal Disease Management
- Psychedelics and Drug Studies
- Epilepsy research and treatment
- Renal function and acid-base balance
- Aging and Gerontology Research
- Intensive Care Unit Cognitive Disorders
- Body Composition Measurement Techniques
University Hospital of Bern
2021-2025
University of Bern
2021-2025
University Hospital of Zurich
2017-2022
University of Zurich
2017-2022
Stadtspital Waid
2017
University Hospital of Basel
2011
Potentially inappropriate medication (PIM) exposes patients to an increased risk of adverse outcomes. Many lists explicit criteria provide guidance on identifying PIM and recommend alternative prescribing, but the complexity available limits their applicability amount data prescribing.
Introduction Kidney stones are a global healthcare problem. Given high recurrence rates and the morbidity associated with symptomatic stone disease, effective medical prophylaxis is clearly an unmet need. Explanatory analyses of randomised controlled trials sodium/glucose cotransporter isoform 2 inhibitors indicated 30%–50% reduced rate events in patients diabetes. Underlying mechanisms remain unclear. We aim to determine effect empagliflozin on urinary supersaturations non-diabetic kidney...
Context. Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone. Case. We report 31-year-old man who ingested dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, hallucinations lasting for 2 days. was detected in the patient's plasma by gas chromatography mass spectrometry at concentrations 0.03 0.02 mg/L, 40 60 h after intake, respectively. Discussion. Based on present case user...
To compare the prevalence of healthy aging among adults age 70 and older from 5 European countries recruited for DO-HEALTH clinical trial. Participants were selected absence prior major health events.
Background The majority of patients with B-cell-depleting therapies show compromised vaccination-induced immune responses. Herein, we report on the trajectories anti-SARS-CoV-2 responses in RituxiVac study compared healthy volunteers and investigate immunogenicity a third vaccination previously humoral non-responding patients. Methods We investigated cell-mediated response after SARS-CoV-2 messanger RNA history anti-CD20 therapies. Coprimary outcomes were antispike SARS-CoV-2-stimulated...
Efficacy of sodium-glucose cotransporter 2 inhibitors for kidney stone prevention in nondiabetic patients is unknown. In a double-blind, placebo-controlled, single-center, crossover phase trial, 53 adults (≥18 and <75 years) with calcium (n = 28) or uric acid (UA; n 25) stones (at least one previous event) without diabetes (HbA1c < 6.5%, no treatment) were randomized to once daily empagliflozin 25 mg followed by placebo reverse (2 weeks per treatment). Randomization analysis performed...
Obesity and sarcopenia are major causes of morbidity mortality among seniors. Vitamin D deficiency is very common especially seniors has been associated with both muscle health obesity. This study investigated if 25-hydroxyvitamin (25(OH)D) status body composition insulin resistance using baseline data a completed RCT relatively healthy community-dwelling (271 age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis...
Objective To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Methods Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing joint replacement due to severe osteoarthritis were 6–8 weeks surgery randomly assigned receive (2000 IU) or standard-dose (800 3 . The primary endpoints symptoms (Western Ontario McMaster Universities Arthritis Index pain function scores) assessed at baseline, 6, 12, 18 24...
Objectives To determine whether statin use alters response of 25‐hydroxyvitamin D (25( OH )D) level to vitamin treatment. Design Pooled analysis. Setting Three double‐blind randomized controlled trials that tested different doses D. Participants three (N = 646; mean age 76.3 ± 8.4, 65% female). Measurements In all trials, 25( )D status and were assessed repeatedly over time (baseline, 6 12 months). Repeated‐measures analysis was used compare treatment at baseline months users nonusers,...
The spectrum of diseases with overactive renin-angiotensin-aldosterone system (RAS) or elevated circulating FGF23 overlaps, but the relationship between aldosterone and remains unclarified. Here, we report that systemic RAS activation sensitively assessed by urinary tetrahydroaldosterone excretion is associated C-terminal FGF23. We performed a retrospective analysis in Bern Kidney Stone Registry, single-center observational cohort kidney stone formers. Urinary main metabolite was measured...
Abstract Background Morbidity and mortality of COVID-19 is increased in patients with B-cell depleting therapies, the majority which also show compromised vaccination-induced immune responses. Herein, we report on trajectories anti-SARS-CoV-2 antibodies from original RituxiVac study compared to healthy volunteers investigate immunogenicity a third vaccination previously non-responding patients. Methods A follow-up evaluation was performed Study ( NCT04877496 ), investigated humoral...
Inconsistent study results and contradictory recommendations from health authorities regarding the use of apixaban in patients on hemodialysis have generated considerable uncertainty among clinicians, making investigations appropriate dosing an unmet need.
Exposure to high ambient temperatures is associated with a risk of acute kidney injury. However, evidence comes from emergency departments or extreme weather exposures. It unclear whether temperature-related adverse outcomes can also be detected at community level in temperate climate zone.
In kidney transplant (KT) patients, magnesium (Mg
Acute pancreatitis is an infrequent but challenging cause of peritonitis in peritoneal dialysis (PD). Presentation often indistinguishable from infectious peritonitis, interpretation pancreatic enzymes not straight-forward, and multiple etiologies need to be considered.
Zusammenfassung. Die körperliche Untersuchung unkooperativer älterer Patienten stellt Ärzte in der Praxis, im Spital oder Pflegeheim regelmässig vor grosse Herausforderungen. Der Mangel an Kooperation selbst kann dabei ein wichtiger Hinweis auf eine unterliegende medizinische Problematik sein. Wichtige Elemente, um die des zu verbessern, beinhalten das Sicherstellen von Grundbedürfnissen, ausreichend Zeit und Geduld, adäquate Kommunikation sowie gute Zusammenarbeit mit den Angehörigen...
ABSTRACT Objectives The individual and socioeconomic burden of sarcopenia in rheumatoid arthritis (RA) is most relevant. However, longitudinal cohort data are scarce. Methods Prospective, single-center, controlled, observational study consecutive 124 postmenopausal women, 53 with RA, 71 healthy controls (HC). Low muscle mass low strengths was defined according to the European working group on older people 2019 (appendicular lean index [ALMI] via dual-energy x-ray absorptiometry < 5.5 Kg/m...
Abstract Background Apixaban is increasingly being used in hemodialysis patients. However, uncertainty remains regarding appropriate dosing and risk of accumulation. Methods We analyzed apixaban drug levels from a tertiary care dialysis unit collected between August 2017 January 2023. compared 2.5 mg once versus twice daily dosing. applied mixed-effects models analyses including modality, adjusted standard Kt/V, ultrafiltration dialyzer characteristics. Results 143 24 Mean (SD) age was 64.2...
Introduction: Early screening for physical frailty among the growing segment of senior adults may help prevent disability and loss autonomy. However, to date, an internationally accepted operational definition is lacking. Methods: We assessed prevalence in all 2158 community-dwelling DO-HEALTH participants age 70 older (mean 75 years, 62% women) from 5 European countries based on instruments: Fried phenotype, SOF-index, FRAIL-scale, SHARE-frailty criteria index. The are Switzerland (n=1008),...