A5057441772- Frailty in Older Adults
- Nutrition and Health in Aging
- Hip and Femur Fractures
- Balance, Gait, and Falls Prevention
- Body Composition Measurement Techniques
- Bone health and osteoporosis research
- Cerebral Palsy and Movement Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin D Research Studies
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Bone health and treatments
- Chronic Disease Management Strategies
- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Intensive Care Unit Cognitive Disorders
- Knee injuries and reconstruction techniques
- Physical Activity and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Effects of Vibration on Health
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Vitamin C and Antioxidants Research
- Emergency and Acute Care Studies
- Pharmacological Effects and Assays
University of Zurich
2018-2025
University Hospital of Zurich
2019-2025
Stadtspital Waid
2018-2024
St Vincent Hospital
2010
Multinational prevalence data on sarcopenia among generally healthy older adults is limited. The aim of the study was to assess in DO-HEALTH European trial based twelve current definitions. This an analysis including 1495 2157 community-dwelling participants age 70+ years from Germany, France, Portugal, and Switzerland with complete measurements toolbox muscle mass by DXA, grip strength, gait speed. definitions applied were Asian Working Group Sarcopenia (AWGS1), AWGS2, Baumgartner,...
We examined vertebral fracture (VF) prevalence, incidence, and treatment among 1488 older adults. VF prevalence incidence were higher in women, participants, those with low bone density. In addition to VFs being underdiagnosed (only 20.7% of clinically recognized), rates low, underscoring the need for improved screening management. To estimate osteoporotic progressions overall by sex, age, status describe proportion participants reporting osteoporosis (OP) medication use. This observational...
To investigate whether serum total testosterone level is associated with knee pain and function in men women severe osteoarthritis (OA).We enrolled 272 adults age ≥60 years (mean ± SD 70.4 4.4 years, 53% women) who underwent unilateral replacement (TKR) due to OA. Serum levels Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) of the operated contralateral were measured at 6-8 weeks after surgery. At nonoperated knee, 56% participants had radiographic OA a Kellgren/Lawrence...
Obesity and sarcopenia are major causes of morbidity mortality among seniors. Vitamin D deficiency is very common especially seniors has been associated with both muscle health obesity. This study investigated if 25-hydroxyvitamin (25(OH)D) status body composition insulin resistance using baseline data a completed RCT relatively healthy community-dwelling (271 age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis...
Objective To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Methods Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing joint replacement due to severe osteoarthritis were 6–8 weeks surgery randomly assigned receive (2000 IU) or standard-dose (800 3 . The primary endpoints symptoms (Western Ontario McMaster Universities Arthritis Index pain function scores) assessed at baseline, 6, 12, 18 24...
Background: Frailty is a geriatric syndrome associated with multiple negative health outcomes. However, its prevalence varies by population and instrument used. We investigated frailty pre-frailty 5 instruments in community-dwelling older adults enrolled to randomized-controlled trial European countries. METHODS: Cross-sectional baseline analysis 2,144 DO-HEALTH participants recruited from Switzerland, Austria, France, Germany, Portugal complete data for frailty. status was assessed the...
While grip strength (GS) is commonly assessed using a Dynamometer, the Martin Vigorimeter was proposed as an alternative method especially in older adults. However, its reference values for Swiss adults are missing. We therefore aimed to derive sex- and age-specific GS cut-points dominant non-dominant hand (DH; NDH) Vigorimeter. Additionally, we identify clinically relevant weakness assess convergent validity with key markers of physical function sarcopenia generally healthy adults.This...
Objectives Falling and living alone have been identified as public health challenges in an ageing society. Our study investigates whether influences fall risk community-dwelling older adults Switzerland. Design methods Secondary analysis of three randomised controlled trials investigating how different doses vitamin D exercise programme may influence the further falls people 60+ at falling. We used logistic regression to examine association between odds becoming a faller, negative binomial...
There is no consensus on the most reliable method of ascertaining falls among elderly. Therefore, we investigated which captured prefrail and frail seniors from 2 randomized controlled trials conducted in Zurich, Switzerland: an 18-month trial (2009–2010) including 200 community-dwelling with a prior fall 12-month (2005–2008) 173 acute hip fracture. Both included same methods ascertainment: monthly active asking, daily self-report diary entries, call-in hotline. We compared numbers reported...
<h3>Introduction</h3> Few if any studies have been conducted to date on the association between polypharmacy and cognitive impairment among older trauma patients. Therefore, we investigated whether is associated with in patients aged ≥70 years. <h3>Methods</h3> This a cross-sectional study of years hospitalised due trauma-related injury. Cognitive was defined as Mini-Mental State Examination (MMSE) score ≤24 points. Medications were coded according Anatomical Therapeutic Chemical...
To test whether transdermal testosterone at a dose of 75 mg per day and/or monthly 24'000 IU Vitamin D reduces the fall risk in pre-frail hypogonadal men aged 65 and older.
The association between fall risk-increasing drugs (FRIDs, medications known to be associated with falls) and the number of falls among generally healthy active community-dwelling older adults is understudied. Prior studies have focused on individual medication classes or predominantly relied retrospective assessments falls. aim this study was investigate FRID use at baseline prospective incidence rates total, injurious recurrent in adults. This a 3-year observational analysis DO-HEALTH,...
Summary In this observational study a SMS reminder system was tested to improve patient adher- ence osteoporosis drug therapy. 399 of 1323 fracture patients could be documented. 66 % who received recommendation arranged an ap- pointment with their primary care physician. A large proportion the physicians followed these recommendations. As more elderly declined participate, tool seems useful in younger seniors (< 70 years).
Abstract Background We aimed to investigate the effect of daily supplemental vitamin D, omega‐3s, and a thrice‐weekly home exercise program, alone or in combination, on change appendicular lean muscle mass index (ALMI) incident sarcopenia older adults. Methods This is secondary endpoint analysis 3‐year randomized, double‐blind, placebo‐controlled trial with 2 × factorial design among 2157 community‐dwelling, healthy adults aged 70 + years, from 2012 2018 (DO‐HEALTH). Participants were...
The growing number of older and oldest-old patients often present in the emergency room (ER) with undiagnosed geriatric syndromes posing them at high risk for complications acute care.To develop validate an ER screening tool (ICEBERG) to capture 9 domains patients.For construct validity we performed a chart-based study 129 age 70 years admitted care (pilot 1). For criterion prospective 288 2).In both validation steps, exposure was ICEBERG test performance below above median score (10, range...