A5024507792- Bone health and osteoporosis research
- Bone health and treatments
- Pulmonary Hypertension Research and Treatments
- Bone Metabolism and Diseases
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- Heart Failure Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Hip and Femur Fractures
- Public Administration and Political Analysis
- Parathyroid Disorders and Treatments
- Medical and Health Sciences Research
- European history and politics
- Vitamin D Research Studies
- Sexual Differentiation and Disorders
- Lipoproteins and Cardiovascular Health
- Pituitary Gland Disorders and Treatments
- German History and Society
- German Literature and Culture Studies
- Classical Antiquity Studies
- Estrogen and related hormone effects
- Cardiovascular Function and Risk Factors
University Hospital of Basel
2016-2025
Praxis
2011-2025
Bayer (Germany)
2013-2024
TIB Molbiol (Germany)
2024
Générale-Beaulieu Clinic
2024
University of Basel
2012-2023
University of Lausanne
2023
RWTH Aachen University
2023
Instituto de Investigación Sanitaria del Principado de Asturias
2021
Klinikum Fulda
2018-2020
OBJECTIVE To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users antidiabetes drugs type 2 diabetes. We evaluated they had relation to various types agents. Case and control patients recorded diagnosis diabetes were matched on age, calendar time, general practice, multivariate...
OBJECTIVE—Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim this study was to compare the risk lactic and hypoglycemia among patients type 2 diabetes oral antidiabetes drugs. RESEARCH DESIGN AND METHODS—This nested case-control analysis U.K.-based General Practice Research Database identify who used Within population, all incident cases were identified, case subjects matched up four control based on age, sex, practice,...
Subclinical hypothyroidism is a frequent syndrome affecting about 10 million people in the United States. The management of such patients open to debate. In long-term prospective study we analyzed spontaneous course and value predictive factors development overt thyroid failure. We studied 82 female with subclinical prospectively over mean observation period 9.2 yr. TSH, hormones, reserve after TRH administration, antibodies, clinical parameters were assessed at yearly intervals. cumulative...
Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated loss.This study examines association between use of thiazolidinediones or other oral antidiabetic drugs risk fracture. This nested case-control analysis uses UK General Practice Research Database, including case patients with fracture aged 30 89 years an incident diagnosis January 1994 December 2005 control subjects who were matched on age, sex, calendar time, general practice attended. We...
This study evaluated the effect of physiological, TSH-guided, l-thyroxine treatment on serum lipids and clinical symptoms in patients with subclinical hypothyroidism. Sixty-six women proven hypothyroidism (TSH, 11.7 ± 0.8 mIU/liter) were randomly assigned to receive or placebo for 48 wk. Individual replacement (mean dose, 85.5 4.3 μg/d) was performed based blinded TSH monitoring, resulting euthyroid levels (3.1 0.3 mIU/liter). Lipid concentrations scores measured before after treatment....
Data on the influence of gonadal hormones incident fracture risk in elderly men are limited. We prospectively examined relationship between serum levels testosterone and estradiol future community-dwelling men.A total 609 older than 60 years had been observed January 1989 December 2005, with median duration being 5.8 (up to 13 years). Clinical factors, including bone mineral density lifestyle were assessed at baseline. Serum measured by tandem mass spectrometry. The incidence a low-trauma...
Abstract Bone metabolism follows a seasonal pattern with high bone turnover and loss during the winter. In randomized, open-label 2-year sequential follow-up study of 55 healthy adults, we found that supplementation oral vitamin D3 calcium winter abolished changes in calciotropic hormones markers led to an increase BMD. Supplementation months seems counteract effects D thus may be beneficial as primary prevention strategy for age-related loss. Introduction: characterized by We investigated...
Among the potential risk factors for fragility fractures, bone turnover is considered an important determinant. In a case-cohort control study of 151 elderly men followed prospectively over 6.3 years, high resorption as assessed by S-ICTP was associated with increased osteoporotic fracture, independent BMD. Combining measurements BMD and may improve fracture prediction in men.Approximately one-third fractures occur men. The association between rates has not been well established We examined...
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). RESPITE investigated the safety, feasibility and benefit switching from PDE5i to riociguat in these patients. was a 24-week, open-label, multicentre, uncontrolled study. Patients World Health Organization (WHO) functional class (FC) III, 6-min walking distance (6MWD) 165–440 m, cardiac index <3.0 L·min −1 ·m −2 vascular resistance >400 dyn·s·cm −5...
The objective of this study was to explore the association between use metformin or other antidiabetic drugs, diabetes, and risk pancreatic cancer.We conducted a case-control using UK-based General Practice Research Database (GPRD). Cases had first-time diagnosis cancer, six controls per case were matched on age, sex, calendar time, general practice, number years active history in GPRD before index date. Results further adjusted multivariate logistic regression analyses for potential...
Background The 12-week, phase III Pulmonary Arterial hyperTENsion sGC-stimulator Trial (PATENT)-1 study investigated riociguat in patients with pulmonary arterial hypertension (PAH). Here, we present a prospectively planned analysis of the safety and efficacy subgroup PAH associated connective tissue disease (PAH-CTD). Methods Patients PAH-CTD were further classified post hoc as having systemic sclerosis or PAH-other defined CTD. In PATENT-1, received (maximum 2.5 1.5 mg three times daily)...
In recent years there has been increasing evidence suggesting that epilepsy and its treatment can have adverse effects on bone mineralization calcium metabolism. Many studies shown a significant reduction in mineral density (BMD) an increased fracture risk patients treated with enzyme-inducing antiepileptics (phenobarbital, carbamazepine, phenytoin). It is assumed CYP450-inducing antiepileptic drugs (AEDs) upregulate the enzymes which are responsible for vitamin D metabolism, effect of...
Background Current pulmonary hypertension treatment guidelines recommend use of a risk stratification model encompassing range parameters, allowing patients to be categorised as low, intermediate or high risk. Three abbreviated versions this were previously evaluated in with arterial (PAH) the French, Swedish and COMPERA registries. Our objective was investigate three methods for mostly prevalent PAH chronic thromboembolic (CTEPH), from PATENT-1/2 CHEST-1/2 studies riociguat. Methods Risk...
EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study in patients with pulmonary hypertension treated riociguat. Patients were followed for 1–4 years, and the primary outcomes adverse events (AEs) serious AEs (SAEs), including embolic/thrombotic hemorrhagic events. Here we report data on chronic thromboembolic (CTEPH) receiving a vitamin K antagonist (VKA; n = 683) or non-vitamin oral anticoagulant (NOAC; 198) at baseline. SAEs reported 438...
Abstract Context The risk of fragility fractures is increased in both type 1 and 2 diabetes. Numerous biochemical markers reflecting bone and/or glucose metabolism have been evaluated this context. Objective This review summarizes current data on relation to fracture Methods A group experts from the International Osteoporosis Foundation European Calcified Tissue Society reviewed literature focusing markers, diabetes, diabetes treatments, adults. Results Although resorption formation are low...