Hubert Wirtz
A5028247097- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Obstructive Sleep Apnea Research
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
- Tuberous Sclerosis Complex Research
- Nutrition and Health in Aging
- Pleural and Pulmonary Diseases
- Cancer survivorship and care
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Childhood Cancer Survivors' Quality of Life
- Vascular Anomalies and Treatments
University Hospital Leipzig
2016-2025
Klinik und Poliklinik für Neurologie
2014-2025
Leipzig University
2015-2024
Jena University Hospital
2024
Friedrich Schiller University Jena
2024
Isabela State University
2023
University Medical Center
2023
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2016-2022
German Respiratory Society
2021-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The hypothesis that mechanical distension directly type II cells to secrete was tested stretching cultured on silastic membranes. intracellular Ca 2+ concentration measured in single cells, before and after stretching. A stretch alveolar caused a transient (less than 60 seconds) increase cytosolic followed sustained (15 30 minutes) stimulation secretion. Both mobilization exocytosis exhibited dose-dependence...
After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study comprehensive quality measures including on-site source data verification was performed Germany. 502 consecutive (171 newly diagnosed, 331 prevalent; mean± sd age 68.7±9.4 years, 77.9% males) a mean disease duration 2.3±3.5 years were...
The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with pre-capillary of unknown origin. There considerable variability in the clinical presentation these patients.Using data from Comparative, Prospective Registry Newly Initiated Therapies for Pulmonary Hypertension, we performed a cluster analysis 841 IPAH based on age, sex, diffusion capacity lung carbon monoxide (DLCO; <45% vs ≥45% predicted), smoking status, and presence comorbidities (obesity,...
The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft...
There is a major need for effective, well-tolerated treatments idiopathic pulmonary fibrosis (IPF).To assess the efficacy and safety of autotaxin inhibitor ziritaxestat in patients with IPF.The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 2, were conducted Africa, Asia-Pacific region, Europe, Latin America, Middle East, North America (26 countries). A total 1306 IPF (525 at 106 sites 781 121 2). Enrollment began November 2018 both trials follow-up was completed...
Novel treatments, such as prostanoids or endothelin receptor antagonists, have been introduced for various forms of pulmonary arterial hypertension, but the long-term effects these treatments on portopulmonary hypertension (PPHT) are unknown. In a retrospective analysis, present authors assessed safety and efficacy inhaled iloprost, prostacyclin analogue, bosentan, an antagonist, in patients with PPHT. total, 31 consecutive Child class A B cirrhosis severe PPHT were treated up to 3 yrs...
Background: A high flow of air applied by large bore nasal cannulae has been suggested to improve symptoms chronic respiratory insufficiency. In pediatric patients, high-flow (nHF) ventilation was similarly effective compared noninvasive with a face mask. Objectives: The aim this study describe changes in parameters. Methods: We measured pressure amplitudes during the cycle and mean pressures patients idiopathic pulmonary fibrosis (IPF) COPD. order achieve tidal volume minute measurements,...
The INSIGHTS-IPF registry provides one of the largest data sets clinical and self-reported patient related outcomes including health quality life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations various QoL instruments between each other characteristics at baseline.
Background: Nasal highflow (NHF) provides a warmed and humidified air stream up to 60 L/min. Recent data demonstrated positive effect in patients with acute hypoxemic respiratory failure, especially when caused by pneumonia. Preliminary show decrease hypercapnia COPD. Therefore, NHF should be evaluated as new ventilatory support device. This study was conducted assess the impact of different flow rates on parameters Materials methods: interventional clinical performed suffering from severe...
There is a paucity of observational data on antifibrotic therapy for idiopathic pulmonary fibrosis (IPF). We aimed to assess the course disease IPF patients with and without under real-life conditions.We analysed from non-interventional, prospective cohort study consecutively enrolled 20 interstitial lung expert centres in Germany. Data quality was ensured by automated plausibility checks, on-site monitoring, source verification. Propensity scores were applied account known differences...
Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate of oral compared placebo time to first adjudicated worsening event participants PAH who recently began approved monotherapy.Methods: In this event-driven, double-blind study, we randomly allocated 690 (1:1 ratio) receive or extended-release tablets three times daily. Eligible were using monotherapy for over 30...
Background Pulmonary hypertension (PH) is a common finding in patients with chronic fibrosing idiopathic interstitial pneumonias (IIP). Little known about the response to pulmonary vasodilator therapy this patient population. COMPERA an international registry that prospectively captures data from various forms of PH receiving therapies. Methods We retrieved compare characteristics, treatment patterns, and survival newly diagnosed arterial (IPAH) associated IIP (PH-IIP). Results Compared IPAH...
Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data limited regarding the course QoL. We therefore analysed longitudinal from German INSIGHTS-IPF registry. Clinical status and QoL were assessed at enrollment subsequently 6- to 12-months intervals. A range different questionnaires including St. George's Respiratory Questionnaire (SGRQ) used. Data 424 included; 76.9% male; mean age 68.7 ± 9.1 years, FVC% predicted 75.9 19.4, DLCO%...
Die idiopathische pulmonale Fibrose (IPF) ist eine schwerwiegende und in der Regel zum Tod führende Erkrankung, die bisher nur unzureichend behandelt werden kann. Empfehlungen zur Diagnostik Therapie wurden erstmals im ATS-ERS-Statement Jahr 2000 publiziert <xref idref="JR460-1">1</xref>. Seither haben sich diagnostischen Standards geändert es liegen zahlreiche Therapiestudien zu diesem Krankheitsbild vor, erforderlich machten, bestehenden überarbeiten wissenschaftlich begründete Leitlinie...
Nasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary suggest that may decrease hypercapnia hypercapnic The aim this study was to evaluate the mechanism mediated PCO2 reduction chronic obstructive pulmonary disease (COPD). In 36 COPD (PCO2 > 45 mmHg), evaluated by capillary gas sampling 1 h after breathing under four conditions A D different flow rates...
Summary Objective This study examined the prevalence of mental health conditions in cancer patients, role socioeconomic position relation to that, and use professional care. Methods Prospective cohort with measurements at beginning inpatient treatment (baseline) 3, 9, 15 months after baseline using structured clinical interviews based on DSM‐IV, questionnaires, medical records. Results At baseline, 149 out 502 patients (30%) were diagnosed a condition. Prevalence was associated unemployment...
Abstract Background Texture analysis derived from computed tomography (CT) can provide clinically relevant imaging biomarkers. Node-RADS is a recently proposed classification to categorize lymph nodes in radiological images. The present study sought investigate the diagnostic abilities of CT texture and discriminate benign malignant mediastinal patients with lung cancer. Methods Ninety-one ( n = 32 females, 35%) mean age 64.8 ± 10.8 years were included this retrospective study. was performed...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic is driven by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, which has led to an enormous burden on patient morbidity and mortality. renin–angiotensin–aldosterone system (RAAS) plays a significant role in various pulmonary diseases. Since SARS-CoV-2 utilizes the angiotensin-converting enzyme (ACE)2 receptor exert its virulence pathogenicity, RAAS of particular importance COVID 19. Methods Our preliminary study...
Alveolar type II (ATII) cells are exposed to mechanical stretch during breathing and ventilation. Increased may contribute lung injury. The influence of three stretching patterns (characterized by frequency [min(-1)] - increase in surface area [%]: S40-13, S60-13, S40-30) on parameters apoptosis, necrosis, membrane integrity rat ATII was compared with that static cultures. S40-13 pattern simulated normal breathing. other were chosen study increased amplitude frequency. There no significant...