A5016407970- Trauma Management and Diagnosis
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Trauma and Emergency Care Studies
- Medical Imaging and Pathology Studies
- Cardiac Arrest and Resuscitation
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Nutrition and Health in Aging
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Employment and Welfare Studies
- Pectus Deformity Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Advanced X-ray and CT Imaging
- Emergency and Acute Care Studies
- Ultrasound in Clinical Applications
- Liver physiology and pathology
- Sustainable Supply Chain Management
- COVID-19 and healthcare impacts
- Ocular Diseases and Behçet’s Syndrome
- Biomedical and Engineering Education
- Advanced Radiotherapy Techniques
University Hospital Leipzig
2016-2025
Leipzig University
2017-2024
Patients First
2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2019-2023
Karlsruhe Institute of Technology
2018
University Hospital Frankfurt
2014
Goethe University Frankfurt
2011-2014
University of Duisburg-Essen
2014
Klinikum St. Georg
2013
Victoria University of Wellington
2009
Abstract Background Texture analysis derived from computed tomography (CT) can provide clinically relevant imaging biomarkers. Node-RADS is a recently proposed classification to categorize lymph nodes in radiological images. The present study sought investigate the diagnostic abilities of CT texture and discriminate benign malignant mediastinal patients with lung cancer. Methods Ninety-one ( n = 32 females, 35%) mean age 64.8 ± 10.8 years were included this retrospective study. was performed...
Abstract Patients with rib fractures often suffer from prolonged pain and dyspnea. The purpose of this study was to evaluate the mid- long-term outcomes major predisposing risk factors for clinical limitations such as or reduced lung capacity in patients conservatively managed provide a basis optimizing current therapy. who underwent conservative management between 2014 2018 at level I trauma center were retrospectively reviewed. Inclusion criteria Injury Severity Score (ISS) ≤ 16 points...
Objectives We aimed to develop consensus‐based recommendations for the monitoring of children with Juvenile Idiopathic Arthritis‐associated uveitis (JIAU) in long‐term remission, addressing absence international guidance on schedules these and young people. Methods The Multinational Interdisciplinary Working Group Uveitis Childhood (MIWGUC) convened experts from ten countries, including paediatric rheumatologists ophthalmologists, alongside parents affected children. A review key...
Abstract Background T-cell retargeting to eliminate CEACAM5-expressing cancer cells via CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly due insufficient activation, dose-limiting toxicities, and formation of anti-drug (ADA). Methods We present here the generation preclinical development NILK-2301, a BsAb composed common heavy chain two different light chains, one kappa lambda, determining specificity (so-called κλ body format). Results NILK-2301...
A group of 72 patients who had received radiotherapy between 1972 and 1980 for isolated local-regional recurrence breast cancer was studied; 38 adjuvant chemotherapy 34 not. The two groups were comparable except the initial nodal status median time from mastectomy to recurrence. Outcome not significantly different in terms response radiotherapy, incidence re-recurrence, distant metastases, three-year survival. length disease-free interval only factors studied that related
Iatrogenic tracheal ruptures are rare but severe complications of medical interventions. The main goal this study was to explore prognostic factors for all-cause mortality and rupture-related (adjusted) mortality. We retrospectively analyzed patients admitted an academic referral center over a 15-year period (2004-2018). Fifty-four met the inclusion criteria, whom 36 underwent surgical repair 18 were treated conservatively. In 90-day follow-up, 50%, while adjusted 13%. Rupture length...
Background Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior and can lead to blindness. Adherence current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified need simplify enable local eye care professionals (ECPs), who carry main burden, screen children with appropriately confidence. Methods...
Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MSC) improved circulatory maintenance and supported multi-organ functions 70% resection. Mechanisms behind beneficial MSC effects remained unknown. Here performed resection pigs with without treatment, animals were monitored 24 h post surgery. Gene expression profiles determined lung...
Despite novel immunotherapies being approved and established for the treatment of non-small cell lung cancer (NSCLC), ex vivo models predicting individual patients' responses to are missing. Especially immune modulating therapies with moderate response rates urge biomarkers and/or assays determine prediction investigate resistance mechanisms. Here, we describe a standardized tissue culture model tumor responses. NSCLC cultures preserve morphological characteristics baseline specimen up 12...
Chest compressions during cardiopulmonary resuscitation (CPR) may be associated with iatrogenic chest wall injuries. The extent to which these CPR-associated injuries contribute a delay in the respiratory recovery of cardiac arrest survivors has not been sufficiently explored. In single-center retrospective cohort study, surviving intensive care unit (ICU) patients, who had undergone CPR due medical reasons between 1 January 2018 and 30 June 2019, were analyzed regarding injuries, detected...
The breathing phase for the determination of thoracic indices in patients with pectus excavatum is not standardized. aim this study was to identify best period reliable assessments morphologic by dynamic observations chest wall using real-time MRI.In prospective study, underwent evaluation MRI at 3 T between January 2020 and June 2021. Haller index (HI), correction (CI), modified asymmetry (AI), eccentricity (EI) were determined during free, quiet, forced respectively. Breathing-related...
Abstract Iatrogenic pneumothorax is a relevant complication of computed tomography (CT)-guided percutaneous lung biopsy. The aim the present study was to analyze prognostic significance texture analysis, emphysema score and muscle mass derived from CT-imaging predict postinterventional after CT-guided Consecutive patients undergoing biopsy between 2012 2021 were analyzed. Multivariate logistic regression analysis included clinical risk factors features detect associations with development....
Tracheobronchial injury (TBI) is the subsuming term to describe rare and mostly traumatic damage tracheobronchial tree. Prehospital mortality significant. TBI patients may face delayed diagnosis, challenging perioperative care, prolonged recovery. The focus of this case series identify issues that represent common hurdles potential problems in treatment, postoperative care with TBI.
Purpose : To determine the effects of surgical IOP reduction (trabeculectomy) on retinal blood flow parameters in glaucoma patients using Dynamic Vessel Analysis (DVA). Methods 26 eyes with progressive primary open-angle (POAG) despite maximal topical therapy were examined before and after trabeculectomy. The responses vessels to flickering light provocation measured DVA day surgery 4 6 weeks Between 3 all local therapies stopped a systemic acetazolamide conservative free topic steroidal eye...
Zusammenfassung Hintergrund Die Corona-Pandemie stellt Krankenhäuser vor enorme finanzielle Herausforderungen. Am Beispiel einer Klinik für Viszeral‑, Transplantations‑, Thorax- und Gefäßchirurgie (VTTG) soll die Leistungsentwicklung in der stationären Versorgung ersten 7 Wochen nach Beginn gesetzgeberisch angeordneten Leistungsreduktion im Vorjahresvergleich sowie eine Bewertung festgelegten Kompensationsmaßnahmen bewertet werden. Methodik Anhand Leistungszahlen wird ein Vergleich des...
Iatrogenic tracheal ruptures are rare but life-threatening airway complications that often require surgical repair. Data on perioperative vital functions and anesthetic regimes scarce. The goal of this study was to explore comorbidity, management, outcomes patients undergoing thoracotomy for repair.We retrospectively evaluated adult who required right emergency repair iatrogenic posterior were admitted a university hospital over 15-year period (2004-2018). analyses included demographic,...
Background Emergency tracheal intubation during major trauma resuscitation may be associated with unrecognised endobronchial intubation. The risk factors and outcomes this issue have not previously been fully defined. Methods We retrospectively analysed adult patients admitted directly from the scene to ED of a single level 1 centre, who received either prehospital or prior initial whole-body CT January 2008 December 2019. Our objectives were describe tube-to-carina distances (TCDs) via...
In a cardiac procedure room, ventilated by ventilation and air-conditioning system with turbulent mixed airflow, protection zone in the operating area could be defined through visualization of airflows. Within this zone, no turbulence was detectable room air.Under given conditions, disinfection all surfaces including furniture equipment after last operation subsequent draping that not removed from sterile surgical drapes improved indoor air quality cleanroom class C to B. This also allows...