A5052832772- Adipose Tissue and Metabolism
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Nanoparticles: synthesis and applications
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Animal Behavior and Reproduction
- Liver Disease and Transplantation
- Gut microbiota and health
- Immune Response and Inflammation
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Toxic Organic Pollutants Impact
- Physiological and biochemical adaptations
- Mesenchymal stem cell research
- Protease and Inhibitor Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Genetics and Physical Performance
Helmholtz Centre for Environmental Research
2017-2025
German Centre for Integrative Biodiversity Research
2023
Leipzig University
2012-2023
Landesamt für Denkmalpflege Hessen
2021
University of Namur
2020
University of Bucharest
2020
Federal Institute for Risk Assessment
2020
BASF (United States)
2020
University of Oxford
2018-2019
University of Groningen
2008-2013
Activation of the NLRP3 inflammasome enables monocytes and macrophages to release high levels interleukin-1β during inflammatory responses. Concentrations extracellular calcium can increase at sites infection, inflammation or cell activation. Here we show that increased activates via stimulation G protein-coupled sensing receptors. is mediated by signalling through calcium-sensing receptor GPRC6A phosphatidyl inositol/Ca(2+) pathway. The resulting in intracellular concentration triggers...
Extibacter muris is a newly described mouse gut bacterium which metabolizes cholic acid (CA) to deoxycholic (DCA) via 7α-dehydroxylation. Although bile acids influence metabolic and inflammatory responses, few in vivo models exist for studying their metabolism impact on the host. Mice were colonized from birth with simplified community Oligo-MM12 or without E. muris. As of known affect lipid homeostasis, mice fed either low- high-fat diet eight weeks before sampling analyses targeting liver....
Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be controlled T helper (Th)1 cells while Th2 are associated with fungal growth and dissemination. Although cryptococcal immunoreactive protein antigens were previously identified, their association Th1 or immune responses was not provided. In mice, Th1-dependent IFN-γ induces the production of IgG2a, whereas cytokine IL-4 stimulates expression IgG1 rendering each isotype an indicator underlying Th cell response....
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of plasticizer di-(2-ethylhexyl)-phthalate (DEHP), search for safe substitutes gained importance. Focusing on master regulator adipogenesis and functionality, peroxisome proliferator-activated receptor gamma (PPARγ), we evaluated 20 alternative plasticizers well their metabolites binding activation PPARγ assessed effects...
Abstract Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly standard treatment. GMP-manufactured skin-derived ABCB5 + mesenchymal stem cells (MSCs) might provide a new adjunctive DFU treatment, based on their remarkable skin wound homing engraftment potential, ability adaptively inflammatory signals, healing-promoting efficacy in mouse models human chronic venous...
The danger signal extracellular calcium is pathophysiologically increased in the synovial fluid of patients with rheumatoid arthritis (RA). Calcium activates NLRP3-inflammasome via calcium-sensing receptor monocytes/macrophages primed by lipopolysaccharide, and this effect mediated uptake calciprotein particles (CPPs) formed out calcium, phosphate, fetuin-A. Aim study was to unravel influence on monocytes when priming not present. Monocytes were isolated from blood healthy controls RA...
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption adipocyte differentiation, interference with obesity mechanisms, and impairment insulin- glucose homeostasis. Substitute compounds are increasingly emerging but not sufficiently investigated.We aimed investigate the mode action BPA four its substitutes during differentiation human preadipocytes adipocytes their molecular interaction peroxisome...
Emerging studies revealed that the Aryl hydrocarbon receptor (AhR), a sensing environmental contaminants, is executing an immunomodulatory function. However, it open question to which extent this achieved by its role as transcription factor or via non-genomic signaling. We utilized multi-post-translational modification-omics approach examine AhR-signaling after activation with endogenous (FICZ) exogenous (BaP) ligand in endotoxin-activated (LPS) monocyte-derived macrophages. While AhR...
Since hepatocytes produce majority of serum proteins, patients with cirrhosis display substantial alterations in the proteome. The aim current study was to characterize these changes and prognostic utility hepatocellular proteins available routine clinical testing.Sera from 29 healthy controls 43 were subjected untargeted proteomic analysis. Unsupervised hierarchical clustering performed Perseus software R. Ingenuity pathway analysis (IPA) suggested upstream regulators that validated liver...
Many animal species employ natural hypothermia in seasonal (hibernation) and daily (torpor) strategies to save energy. Facultative torpor is a typical response fluctuations food availability, but the relationship between environmental quality, foraging behaviour responses poorly understood. We studied body temperature of outbred ICR (CD-1) mice exposed different reward schedules, simulating variation habitat quality. Our main comparison was female low foraging-cost environments high-cost...
In respect to the high number of released nanomaterials and their highly variable properties, novel grouping approaches are required based on effects nanomaterials. Proper calls for a combination an experimental setup with higher structurally similar employing integrated omics identify mode action. Here, we analyzed seven well-characterized NMs comprising different chemical compositions, sizes surface modifications rat alveolar macrophage cell line NR8383. The were investigated at three...
The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in manufacture plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, asthma, for which inflammation described be a driving factor. emerging alternative 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on immune system. Here, we investigated DINCH naturally occurring metabolite...
In past times, the analysis of endocrine disrupting properties chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well aspects steroidogenesis and modulation thyroid signaling. More recently, disruption energy metabolism related signaling pathways by exogenous substances, so-called metabolism-disrupting (MDCs) have come into focus. While general effects such body organ weight changes are routinely monitored in animal studies, there is a clear lack...
Dominance relationships structure many animal societies, yet the process of rank attainment is poorly understood. We investigated acquisition social dominance in winter flocks and its fitness consequences male black-capped chickadees (Poecile atricapillus) over a 10-year period. Age was best predictor rank, paired comparisons showed high-ranked males to be older than their low-ranked flock-mates. When controlling for age, morphological variables did not predict but were heavier, had lower...
The proposition that increased energy expenditure shortens life has a long history. rate-of-living theory (Pearl 1928 ) states span and average mass-specific metabolic rate are inversely proportional. Originally based on interspecific allometric comparisons between species of mammals, the was later rejected basis taxa (e.g., birds have higher rates than mammals same size yet live longer). It rarely been experimentally tested within species. Here, we investigated effects expenditure, induced...
Abstract Background Nanomaterials (NMs) can be fine-tuned in their properties resulting a high number of variants, each requiring thorough safety assessment. Grouping and categorization approaches that would reduce the amount testing are principle existing for NMs but still mostly conceptual. One drawback is limited mechanistic understanding NM toxicity. Thus, we conducted multi-omics vitro study RLE-6TN rat alveolar epithelial cells involving 12 covering different materials including...
Glyphosate is the world's most widely used herbicide, and its potential side effects on intestinal microbiota of various animals, from honeybees to livestock humans, are currently under discussion. Pigs among abundant animals worldwide an impact glyphosate their function can have serious consequences health, not mention economic effects. Recent studies that addressed microbiota-disrupting focused microbial taxonomy but lacked functional information. Therefore, we chose experimental design...
Human white adipose tissue (AT) is a metabolically active organ with distinct depot-specific functions. Despite their locations close to the gastrointestinal tract, mesenteric AT and epiploic (epiAT) have only scarcely been investigated. Here, we aim characterise these ATs in-depth estimate contribution alterations in whole-body metabolism.Mesenteric, epiploic, omental abdominal subcutaneous were collected from 70 patients obesity undergoing Roux-en-Y gastric bypass surgery. The...