A5073276567- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Autophagy in Disease and Therapy
- Nail Diseases and Treatments
- Effects of Environmental Stressors on Livestock
- Asthma and respiratory diseases
- Parasitic Diseases Research and Treatment
- Muscle Physiology and Disorders
- Immune Cell Function and Interaction
- Neurogenetic and Muscular Disorders Research
- Veterinary Equine Medical Research
- Neuroinflammation and Neurodegeneration Mechanisms
Max Delbrück Center
2023
Leipzig University
2018-2022
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2021
Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be controlled T helper (Th)1 cells while Th2 are associated with fungal growth and dissemination. Although cryptococcal immunoreactive protein antigens were previously identified, their association Th1 or immune responses was not provided. In mice, Th1-dependent IFN-γ induces the production of IgG2a, whereas cytokine IL-4 stimulates expression IgG1 rendering each isotype an indicator underlying Th cell response....
Abstract The ability of the fungal pathogen Candida albicans to undergo a yeast-to-hypha transition is believed be key virulence factor, as filaments mediate tissue damage. Here, we show that not necessarily reduced in filament-deficient strains, and results depend on infection model used. We generate strain by deletion or repression EED1 (known required for maintenance hyphal growth). Consistent with previous studies, attenuated damaging epithelial cells macrophages vitro mouse...
Skeletal muscle atrophy is a pathological condition characterized by the progressive loss of mass and function, driven factors such as disuse, inflammation, aging. While ubiquitin-proteasome system established central mediator myofibrillar protein degradation, role autophagy in selective turnover remains largely unexplored. To address this, we employed quantitative, time-resolved analysis synthesis degradation C2C12 myotubes undergoing TNF-α-induced atrophy, using dynamic Stable Isotope...
Equine asthma (EA) is a highly relevant disease, estimated to affect up 20% of all horses, and compares human asthma. The pathogenesis EA most likely immune-mediated, yet incompletely understood. To study the immune response in affected lower airways, mixed leukocytes were acquired through bronchoalveolar lavage (BAL) cell populations analyzed on single-cell basis by flow cytometry (FC). Samples 38 horses grouped as respiratory healthy or mild moderate (mEA) severe (sEA) according their...
Cryptococcus neoformans , an opportunistic fungal pathogen ubiquitously present in the environment, causes cryptococcal meningitis (CM) mainly immunocompromised patients, such as AIDS patients. We aimed to identify disease-associated protein antigens targeted by human humoral immune response. Therefore, we used sera from Colombian CM with or without HIV infection, and healthy individuals living same region. Serological analysis revealed increased titers of anti-cryptococcal IgG HIV-negative...