A5078610248- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Obstructive Sleep Apnea Research
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Sleep and related disorders
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Sleep and Work-Related Fatigue
- Air Quality Monitoring and Forecasting
- Microfluidic and Bio-sensing Technologies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Microfluidic and Capillary Electrophoresis Applications
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Peptidase Inhibition and Analysis
- Pediatric health and respiratory diseases
Taipei Medical University-Shuang Ho Hospital
2016-2025
Taipei Medical University
2015-2025
Royal Brompton Hospital
2023
Ministry of Health and Welfare
2023
Isabela State University
2023
Pulmonary Associates
2021
Brigham and Women's Hospital
2020
Cornell University
2020
Princeton University
2020
Federation of American Societies for Experimental Biology
2020
Abstract Background: Recent trials have demonstrated the clinical benefit of immunotherapy in either neoadjuvant or adjuvant resectable (R) NSCLC setting. AEGEAN (NCT03800134) is a randomized, double-blind, placebo (PBO)-controlled trial assessing durvalumab (D) + chemotherapy (CT) followed by surgery (Sx) and D patients (pts) with R-NSCLC. Methods: Adults treatment (Tx)-naïve R-NSCLC (stage II-IIIB[N2]; AJCC 8th ed) ECOG PS 0/1 were randomized (1:1) to receive 1500 mg PBO IV platinum-based...
There is a major need for effective, well-tolerated treatments idiopathic pulmonary fibrosis (IPF).To assess the efficacy and safety of autotaxin inhibitor ziritaxestat in patients with IPF.The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 2, were conducted Africa, Asia-Pacific region, Europe, Latin America, Middle East, North America (26 countries). A total 1306 IPF (525 at 106 sites 781 121 2). Enrollment began November 2018 both trials follow-up was completed...
Abstract Abnormal expression of TGF-β1 is believed to play an important role in the pathogenesis a number chronic inflammatory and immune lung diseases, including asthma, obstructive pulmonary disease, fibrosis. Gene activation eukaryotes requires coordinated use specific cell signals, chromatin modifications, remodeling. We studied roles ubiquitous transcription factors, NF-κB AP-1, gene histone acetylation at promoter. IL-1β-induced protein secretion mRNA were prevented by actinomycin D...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous family of myeloid that suppress T-cell immunity in tumor-bearing hosts. Their clinical relevance remains unclear.To identify subtypes myeloid-derived patients with non-small cell lung cancer (NSCLC) and their relevance.CD11b(+)CD14(-) CD11b(+)CD14(+) cells, determined phenotyped by fluorescence-activated sorter analysis, the peripheral blood mononuclear (PBMCs) treatment-naive advanced NSCLC were correlated data. activation...
397600 Background: While PD-1 inhibitors demonstrated survival benefit compared to chemotherapy in patients (pts) with PD-L1-high, NSCLC, less than half of pts respond monotherapy. Novel therapeutics or combinations are necessary improve outcomes. Domvanalimab (D) is an Fc-silent humanized IgG1 monoclonal antibody (mAb) that blocks T cell Immunoglobulin and ITIM domain (TIGIT), thereby reducing immunosuppression T/NK cells promoting antitumor activity. Etrumadenant (E) a selective dual...
Abstract Impaired lung function is associated with morbidity and mortality in the elderly. However, there a paucity of data regarding long-term effects particulate matter (PM) on among This study evaluated exposure-response relationship between ambient PM different indices elderly Taiwan. A cross-sectional survey individuals aged ≥65 years was conducted Taiwan from October 2015 to September 2016. Those who attended annual health examination for five hospitals varying background...
Lung cancer (LC) causes the majority of cancer-related deaths. Circular RNAs (circRNAs) were reported to play roles in cancers by targeting pro- and anti-oncogenic miRNAs. However, mechanisms circRNAs LC progression their prognostic value treatment response remain unclear. By using next generation sequencing (NGS) cell lines' transcriptomes, we identified highly overexpressed hsa_circ_0000190 hsa_circ_000164 as potential biomarkers. sensitive RT-ddPCR method, these shown be secreted lines...
Lung cancer is the most commonly diagnosed worldwide, and metastasis in lung leading cause of cancer-related deaths. Thus, understanding mechanism will improve diagnosis treatment patients. Herein, we found that expression cluster differentiation 109 (CD109) was correlated with invasive metastatic capacities adenocarcinoma cells. CD109 upregulated tumorous tissues, overexpression associated tumor progression, distant metastasis, a poor prognosis patient adenocarcinoma. Mechanistically,...
Abstract Expression of the inflammatory chemokine, growth-related oncogene protein-α (GRO-α), from airway smooth muscle cells (ASMC) is regulated by pathways involving NF-κB and MAPK activation. We determined effects dexamethasone on GRO-α induced IL-1β or TNF-α with respect to role phosphatase-1 (MKP-1). Human ASMC were studied in primary culture at confluence. Dexamethasone (10−8–10−5 M) partially inhibited expression release TNF-α; this was associated an inhibition JNK, but not p38 ERK...
Long-term exposure to air pollution can lead cardiovascular disease, metabolic syndrome, and chronic respiratory disease. However, from a lifetime perspective, the critical period of in terms health risk is unknown. This study aimed evaluate impact at different life stages. The participants were recruited community centers Northern Taiwan between October 2018 April 2021. Their annual averages for fine particulate matter (PM2.5) derived national visibility database. Lifetime PM2.5 exposures...
Abstract Adenosine is a potent endogenous regulator of airway inflammation that acts through specific receptor subtypes can either cause constriction (A1R, A2BR, and A3R) or relaxation (A2AR) the airways. We therefore examined effects key inflammatory mediators on expression A2AR in lung epithelial cell line (A549). IL-1β TNF-α increased gene at mRNA protein levels. In contrast, LPS had no effect expression. rapidly activated p50 p65, but not C-Rel, RelB, p52, both IL-1β- TNF-α-stimulated...
Abstract Loss of skeletal muscle mass is common with aging and can cause morbidity mortality in the elderly. The effects particulate air pollution on not known. study aims to assess chronic ambient fine particulates (PM 2.5 ) body composition From October 2015 November 2016, a cross-sectional survey 530 elderly (age > = 65 years) was conducted Taipei Basin, Taiwan. measured by bioelectrical impedance analysis (InBody 120). One year exposure estimated using Kriging method at participant’s...
Non-small cell lung cancer (NSCLC) patients harboring a KRAS mutation have unfavorable therapeutic outcomes with chemotherapies, and the also renders tolerance to immunotherapies. There is an unmet need for new strategy overcoming immunosuppression in KRAS-mutant NSCLC. The recently discovered role of melatonin demonstrates wide spectrum anticancer impacts; however, effect on modulating tumor immunity largely unknown. In present study, treatment significantly reduced viability accompanied by...
Acute respiratory distress syndrome (ARDS) contributes to higher mortality worldwide. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have immunomodulatory and regenerative potential. However, the effects of hUC-MSCs as an ARDS treatment remain unclear. We investigated role in differentiation type II alveolar epithelial (AECII) by regulating Yes-associated protein (YAP) ARDS. Male C57BL/6JNarl mice were intratracheally (i.t.) administered lipopolysaccharide (LPS) induce model,...
Background: Silver nanoparticles (AgNPs) have been associated with the exacerbation of asthma; however, immunological basis for adjuvant effects AgNPs is not well understood. Objective: The aim study reported here was to investigate allergic AgNP inhalation using proteomic approaches. Methods: Allergen provoked mice were exposed 33 nm at 3.3 mg/m 3 . Following this, bronchoalveolar lavage fluid (BALF) and plasma collected determine protein profiles. Results: In total, 106 79 AgNP-unique...