A5089354826- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Allergic Rhinitis and Sensitization
- Pneumonia and Respiratory Infections
- Occupational exposure and asthma
- Pleural and Pulmonary Diseases
- Fibroblast Growth Factor Research
- Congenital Diaphragmatic Hernia Studies
- Nursing Diagnosis and Documentation
- Chronic Disease Management Strategies
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Occupational and environmental lung diseases
- Emergency and Acute Care Studies
Far Eastern Memorial Hospital
2016-2025
Yuan Ze University
2016-2025
British Columbia Children's Hospital
2024
Isabela State University
2023
Voestalpine (Brazil)
2021
Nippon Medical School
2021
Taipei Hospital
2021
Kaohsiung Veterans General Hospital
2020
Fukuoka University
2019
Kosin University Gospel Hospital
2019
There is a major need for effective, well-tolerated treatments idiopathic pulmonary fibrosis (IPF).To assess the efficacy and safety of autotaxin inhibitor ziritaxestat in patients with IPF.The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 2, were conducted Africa, Asia-Pacific region, Europe, Latin America, Middle East, North America (26 countries). A total 1306 IPF (525 at 106 sites 781 121 2). Enrollment began November 2018 both trials follow-up was completed...
International and regional prevalence comparisons are required to test generate hypotheses regarding the causes of increasing asthma in various age groups worldwide. The Study Asthma Allergies Childhood (ISAAC) is first such study children European Community Respiratory Health Survey (ECRHS) adults. Therefore, a comparison findings these two surveys was conducted, for 17 countries which both were undertaken. There strong correlation between ISAAC ECRHS data, with 64% variation at country...
The aim of the present study was to assess which factors contribute lower prevalence allergic diseases in farmers’ children, and importance timing exposure. In a cross-sectional questionnaire survey, asthma symptoms, hay fever eczema were assessed, as well current, early prenatal farm-related exposures 1,333 children 566 reference aged 5–17 yrs. Farmers’ had incidence symptoms eczema. Current maternal exposure during pregnancy animals and/or grain reduced risk exposure–response association...
<h3>BACKGROUND</h3> A study was undertaken to investigate the relationship between birth anthropometric measures and subsequent development of asthma, airway hyperresponsiveness, atopy in later childhood. <h3>METHODS</h3> longitudinal performed on 734 subjects (71%) from a cohort children born Dunedin, New Zealand 1972–73. The were available hospital records main outcome reported skin prick tests, methacholine hyperresponsiveness measured at age 13 years, while serum total IgE 11 years....
Farm exposures may protect against childhood asthma, hay fever and eczema. Whether farm also confer protection in adult farmers remains unclear. Moreover, little is known about the role of timing exposure. We assessed effects current on eczema a rural nonfarming control population.We conducted cross-sectional questionnaire survey 2509 farming families (response rate 78%) 1001 67%), which included 4288 1328 nonfarmers.Farmers were less likely to have asthma symptoms, eczema; no significant...
Objectives: To determine the prevalence of COPD in Taiwan and to document disease characteristics associated risk factors. Methods: We conducted a random cross-sectional national survey adults older than 40 years Taiwan. Respiratory health screening questions identified subjects with diagnosed or whose reported symptoms also fulfilled an epidemiological case definition; these were eligible complete survey, which included indices symptom severity disability on comorbidities, medical...
Previous studies have shown that the M72/AS01E candidate tuberculosis vaccine is immunogenic with a clinically acceptable safety profile in healthy and Mycobacterium tuberculosis-infected adults. This phase II, observer-blind, randomised study compared safety, reactogenicity, immunogenicity of 3 cohorts: tuberculosis-naïve adults (n = 80), previously treated for 49), who completed intensive treatment 13). In each cohort, 18-59-year-old were (1:1) to receive two doses 71) or placebo...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposed a new severity assessment system emphasizing clinical symptom evaluation by COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scores. aim of the study was to evaluate effectiveness two scoring systems in evaluating patients. A population based cross-sectional employing computer-assisted telephone interviewing (CATI) surveying epidemiology Taiwan. Among 6600 subjects recruited (age >...
Background: REMIT is the first real-world study of mepolizumab effectiveness in patients with severe asthma (SA) Taiwan. Objectives: The primary objective evaluated changes clinically significant exacerbations (CSEs; defined as use oral corticosteroids (OCS) or emergency department (ED) visits and/or hospitalizations) 12 months pre- and post-mepolizumab treatment. Secondary objectives assessed number CSEs requiring ED visits/hospitalizations daily maintenance OCS (mOCS) dosage Three-...
Background The radiology, obstruction, symptoms and exposure (ROSE) criteria provide a standardised approach for identifying the “COPD–bronchiectasis (BE) association.” However, clinical implications outcomes of COPD–BE association in East Asian populations remain unclear. Our study applied ROSE to assess prevalence, impact an cohort, compared that cohort with nonsmoking BE patients fixed airflow obstruction (FAO) those without FAO. Methods An integrated analysis was conducted within...
Sleep disturbance is a common complaint in patients with chronic obstructive lung disease (COPD). However, the factors resulting sleep remain unclear. This retrospective, observational, multicenter study aimed to identify associated COPD. The was and research. Data including age, sex, body mass index, smoking status, COPD inhaler prescribed, clinical symptoms, pulmonary function tests, medical history of comorbidities, questionnaires were collected. Parameters demographics, medication,...
Summary Background Although pollens are major allergens associated with allergic rhinoconjunctivitis and asthma, there is little information about the relative prevalence of these conditions in populations different pollen exposures. Objective The purpose this study was to investigate relationship between exposure symptoms among children countries. Methods An ecological analysis conducted see whether (pollen counts, duration severity seasons) rhinoconjunctivitis, asthma atopic eczema 28...
SUMMARY This study assessed risk factors for respiratory syncytial virus (RSV) hospitalization and disease severity in Wellington, New Zealand. During the southern hemisphere winter months of 2003–2005, 230 infants aged <24 hospitalized with bronchiolitis were recruited. RSV was identified 141 (61%) infants. Comparison data from all live hospital births same region (2003–2005) revealed three independent hospitalization: birth between February July [adjusted ratio (aRR) 1·62, 95%...
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety nemonoxacin compared levofloxacin patients CAP.A phase 3, multicenter, randomized (2:1) controlled trial conducted adult CAP receiving 500 mg or orally once daily for 7-10 days. Clinical, microbiological response adverse events were assessed....
To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins.Phenoxy (n = 1025) 703) were followed up from 1 January 1969 1973 respectively 31 December 2000. A total of 813 699 classified as dioxin herbicides. Standardised ratios (SMR) calculated using national rates.At the end follow up, 164 91 had died. Cancer was reduced for (SMR 0.82, 95% CI 0.57 1.14) increased production workers 1.24, 0.90 1.67), especially synthesis 1.69), formulation lab 1.64),...
Because of the expansion aging and smoking populations, chronic obstructive pulmonary disease (COPD) is predicted to be third leading cause death worldwide in 2030. Therefore, it pertinent develop effective therapy improve management for COPD. Cigarette smoke-mediated protease-antiprotease imbalance a major pathogenic mechanism COPD results massive infiltration neutrophils macrophages, releasing excessive neutrophil elastase (NE) matrix metalloproteinases (MMPs). Our previous studies...
Blood eosinophil counts have been documented as a good biomarker for patients with chronic obstructive pulmonary disease (COPD) using inhaled corticosteroid (ICS) therapy. However, the effectiveness and safety of prescribing high or medium dose ICS different are unknown.A post hoc analysis previous prospective randomized study was performed COPD higher (HD: Fluticasone 1,000 μg/day) (MD: 500 combined Salmeterol (100 μg/day). Patients were classified into two groups: those (HE ≥3%) low (LE...