A5046374727- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Animal Behavior and Welfare Studies
- Animal Nutrition and Physiology
- Heart Rate Variability and Autonomic Control
- Meat and Animal Product Quality
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- ECG Monitoring and Analysis
- Diabetes Treatment and Management
- EEG and Brain-Computer Interfaces
- Insect and Pesticide Research
- Animal Disease Management and Epidemiology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Rabbits: Nutrition, Reproduction, Health
- Agricultural safety and regulations
- Bladder and Urothelial Cancer Treatments
- Amphibian and Reptile Biology
- Human-Animal Interaction Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Animal testing and alternatives
- Agriculture and Farm Safety
- Eosinophilic Esophagitis
- Veterinary Practice and Education Studies
- Diet and metabolism studies
University of Virginia
2015-2025
Charlottesville Medical Research
2020-2024
University of Veterinary Medicine Vienna
2018
Ghent University
2018
University of Zagreb
2018
University of Ljubljana
2018
Robert Bosch (India)
2018
Flemish Government
2018
University of Padua
1998-2017
European Food Safety Authority
2012
Background: Glucose variability (GV) remains a key limiting factor in the success of diabetes management. While new technologies, for example, accurate continuous glucose monitoring (CGM) and connected insulin delivery devices, are now available, current treatment standards fail to leverage wealth information generated. Expert systems, from automated advisory missing element richer, more personalized, management diabetes. Methods: Twenty four subjects with type 1 mellitus (T1DM), 15 women,...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
The killing of pigs for human consumption (slaughtering) can take place in a slaughterhouse or on farm. processes slaughtering that were assessed welfare, from the arrival until their death, grouped into three main phases: pre-stunning (including arrival, unloading truck, lairage, handling and moving pigs); stunning restraint); bleeding. Stunning methods categories: electrical, controlled atmosphere mechanical. Twelve welfare consequences be exposed to during slaughter identified: heat...
This scientific opinion focuses on the welfare of pigs farm, and is based literature expert opinion. All pig categories were assessed: gilts dry sows, farrowing lactating suckling piglets, weaners, rearing boars. The most relevant husbandry systems used in Europe are described. For each system, highly consequences identified, as well related animal-based measures (ABMs), hazards leading to consequences. Moreover, prevent or correct and/or mitigate recommended. Recommendations also provided...
Objective: To bridge the gap between laboratory-measured hemoglobin A1c (HbA1c) and continuous glucose monitoring (CGM)-derived time in target range (TIR), introducing TIR-driven estimated (eA1c). Methods: Data from Protocol 1 (training data set) 3 (testing of International Diabetes Closed-Loop Trial were used. Training included months CGM recordings 125 individuals with type diabetes, HbA1c at months; testing 9 168 individuals, 3, 6, months. Hemoglobin glycation was modeled by a first-order...
Background: With the proliferation of continuous glucose monitoring (CGM), a number metrics were developed to assess quality glycemic control. Many them are highly correlated. Thus, we aim identify principal dimensions control-a minimal set metrics, necessary and sufficient for comprehensive assessment diabetes management. Methods: Seventy-five thousand five hundred sixty-three 2-week CGM profiles recorded in six studies by 790 individuals with type 1 or 2 used compute mean (MG), percentage...
This document provides methodological guidance developed by the EFSA Panel on Animal Health and Welfare to produce Scientific Opinions in response mandates received from European Commission context of Farm Fork Strategy. The relate welfare (i) animals during transport, (ii) calves, (iii) laying hens, (iv) broilers, (v) pigs, (vi) ducks, geese quails, (vii) dairy cows. was order define methods strategy be applied for responding Terms Reference (ToRs) mandates. each consist a set General ToRs...
ABSTRACT Objectives People with later chronotypes are at greater T2D risk, yet it is unknown if β‐cell function differs among chronotypes. Thus we, assessed in morning (MORN) and intermediate (INT) obesity. Methods Adults ( n = 41, 9M, 55 ± 1.7 y, 36.8 1.0 kg/m 2 ) were grouped as MORN or INT per the Morningness‐Eveningness Questionnaire. Glucose, insulin, C‐peptide, GIP, GLP‐1(active) collected every 30 min during a 120 75g‐OGTT. Insulin secretion rates (ISR) calculated (regularized...
Background: The risk of hypo- and hyperglycemia has been assessed for years by computing the well-known low blood glucose index (LBGI) high (HBGI) on sparse self-monitoring (SMBG) readings. These metrics have shown to be predictive future glycemic events clinically relevant cutoff values classify state a patient defined, but their application continuous monitoring (CGM) profiles not validated yet. aim this article is explore relationship between CGM-based SMBG-based LBGI/HBGI, provide...
The killing of poultry for human consumption (slaughtering) can take place in a slaughterhouse or during on-farm slaughter. processes slaughtering that were assessed, from the arrival birds containers until their death, grouped into three main phases: pre-stunning (including arrival, unloading truck, lairage, handling/removing containers); stunning restraint); and bleeding following slaughter without stunning). Stunning methods categories: electrical, controlled modified atmosphere...
Animal-based measures (ABM) can be used effectively in the on-farm evaluation of broiler welfare relation to laws, codes practice, quality assurance schemes, management and also partly for ante-mortem inspection.Some ABM taken post-mortem at slaughterhouse.Non-animal-based when association between them outcome is strong they are more efficient than as a means safeguard welfare.They useful predictors broilers.The choice animalbased will depend upon specific objectives assessment.The full list...
Background: Abnormal glucose variability (GV) is a risk factor for diabetes complications, and tens of indices its quantification from continuous monitoring (CGM) time series have been proposed. However, the information carried by these redundant, parsimonious description GV can be obtained through sparse principal component analysis (SPCA). We recently shown that set 10 metrics selected SPCA able to describe more than 60% variance 25 indicators in type 1 (T1D). Here, we want extend...
Previous introductions of highly pathogenic avian influenza virus (HPAIV) to the EU were most likely via migratory wild birds. A mathematical model has been developed which indicated that amplification and spread may take place when bird populations sufficient size within become infected. Low (LPAIV) reach similar maximum prevalence levels in HPAIV but risk LPAIV infection a poultry holding was estimated be lower than HPAIV. Only few non-wild pathways identified having non-negligible AI...
Objective: To assess the safety and efficacy of a simplified initialization for Tandem t:slim X2 Control-IQ hybrid closed-loop system, using parameters based on total daily insulin ("MyTDI") in adolescents with type 1 diabetes under usual activity during periods increased exercise. Research Design Methods: Adolescents 12–18 years age used 5 days at home their parameters. Upon arrival 60-h ski camp, participants were randomized to either continue settings or reinitialize MyTDI use continued...
Abstract This Scientific Opinion concerns the welfare of Domestic ducks (Anas platyrhynchos domesticus), Muscovy (Cairina moschata domesticus) and their hybrids (Mule ducks), geese (Anser anser f. Japanese quail (Coturnix japonica) in relation to rearing breeders, birds for meat, Mule foie gras layer egg production. The most common husbandry systems (HSs) European Union are described each animal species category. following consequences assessed species: restriction movement, injuries (bone...
Multiple daily injections (MDI) therapy is the most common treatment for type 1 diabetes (T1D), consisting of long-acting insulin to cover fasting conditions and rapid-acting meals. Titration needed achieve satisfactory glycemia but challenging due inter-and intra-individual metabolic variability. In this work, a novel titration algorithm leveraging continuous glucose monitoring (CGM) smart pens (SIP) data proposed.The based on glucoregulatory model that describes meal effects blood...
Introduction & Objective: The UVLab platform - equipped with a metabolic model and 6062 virtual subjects (VS) type 2 diabetes (T2D) describes T2D heterogeneity. This work evaluates UVLab's ability to replicate the findings from 26-week phase 3 clinical trial (NCT01336023) comparing degludec (IDeg), liraglutaide (Lira), fixed-ratio combination of two (IDegLira). Methods: IDeg, Lira, IDegLira were administered VS according protocol. Subpopulations matching early glycemic metrics selected;...
The effect of work-matched exercise intensity on β-cell function is unknown in people with prediabetes before clinical weight loss. We determined if short-term moderate continuous (CONT) vs. high-intensity interval (INT) increased function. Thirty-one subjects (age: 61.4 ± 2.5 yr; body mass index: 32.1 1.0 kg/m 2 ) [American Diabetes Association criteria, 75-g oral glucose tolerance test (OGTT)] were randomized to CONT (70% HR peak or INT (3 min 90% and 3 50% for 60 min/day over wk. A 2-h...
Batrachochytrium salamandrivorans (Bsal) is an emerging fungal pathogen of salamanders.Despite limited surveillance, Bsal was detected in kept salamanders populations Belgium, Germany, Spain, the Netherlands and United Kingdom, wild some regions Germany Netherlands.According to niche modelling, at least part distribution range every salamander species Europe overlaps with climate conditions predicted be suitable for Bsal.Passive surveillance considered most approach detection emergence...