A5020819189- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Extracellular vesicles in disease
- Dietary Effects on Health
- Physical Activity and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Regulation of Appetite and Obesity
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Digital Mental Health Interventions
- Telemedicine and Telehealth Implementation
- Cardiovascular Function and Risk Factors
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- Eating Disorders and Behaviors
- Exercise and Physiological Responses
- Motivation and Self-Concept in Sports
- Nutritional Studies and Diet
Lebanon Valley College
2024
University of Virginia
2017-2022
Pennsylvania State University
2020-2022
UPMC Altoona
2020
James Madison University
2015-2019
Charlottesville Medical Research
2018
University of Virginia Health System
2017
Bristol Royal Hospital for Children
2013
<h3>Background</h3> The long-term prognosis of Henoch-Schönlein Purpura (HSP) is predominantly determined by the extent renal involvement. There no consensus as to whether treatment with prednisolone at presentation can prevent or ameliorate progression nephropathy in HSP. <h3>Methods</h3> Children under 18 years age new-onset HSP were randomly assigned receive placebo for 14 days. primary outcomes (a) presence proteinuria 12 months (defined urine protein : creatinine ratio (UP UC) >20...
New Findings What is the central question of this study? are effects work‐matched continuous versus high‐intensity interval training for 2 weeks on adiposopathy and cardiometabolic risk in obese adults with prediabetes? main finding its importance? Independent intensity, short‐term exercise improves insulin sensitivity. While both intensities reduced fasting leptin concentrations metabolic syndrome severity, only elevated total adiponectin. In contrast to previous work, neither condition...
The optimal short-term exercise dose to improve glucose tolerance in relation metabolic flexibility and/or insulin resistance is unknown. Therefore, we tested if short-term, work-matched continuous (CONT) versus interval (INT) training improves part by reducing and increasing independent of clinically meaningful fat loss adults with prediabetes.
No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of moderate-continuous (CONT) vs. high-intensity interval (INT) on regulation. Twenty-eight [age: 61.3 ± 1.5 yr; body mass index (BMI): 33.2 1.1 kg/m
The objective of this study was to test if a low-calorie diet plus interval exercise (LCD+INT) improves adiposopathy, an endocrine dysfunction, when compared with energy-deficit-matched LCD in obese women. Subjects (age: 48.2 ± 2.4 years, body mass index: 37.8 1.3 kg/m
Treatment for substance use disorder (SUD) during the COVID-19 pandemic poses unique challenges, both due to direct effects from illness, and indirect physical measures needed "flatten curve." Stress, isolation, lack of structure, limited access mental health care, changes in treatment paradigms all increase risk return drug events pose barriers recovery people with SUDs. The has forced providers facilities rapidly adapt address these threats while redesigning their structure accommodate...
What is the central question of this study? We compared high-intensity interval versus continuous training on fasting and postprandial arterial stiffness in people with prediabetes. main finding its importance? show, for first time, that exercise improves augmentation index during state, but not fasted adults However, improved relationship to dose, as assessed by kilocalories per session. Collectively, these findings suggest short-term can improve compliance Therefore, lifestyle...
The effect of work-matched exercise intensity on β-cell function is unknown in people with prediabetes before clinical weight loss. We determined if short-term moderate continuous (CONT) vs. high-intensity interval (INT) increased function. Thirty-one subjects (age: 61.4 ± 2.5 yr; body mass index: 32.1 1.0 kg/m 2 ) [American Diabetes Association criteria, 75-g oral glucose tolerance test (OGTT)] were randomized to CONT (70% HR peak or INT (3 min 90% and 3 50% for 60 min/day over wk. A 2-h...
Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) additive. We examined the impact of an LCD versus + INT training on ß-cell function in relation to tolerance obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 6 kg/m2) were randomized 2-week (~1200 kcal/day) or energy-matched (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral test (OGTT) was performed. Insulin secretion rates (ISR) determined by deconvolution...
Low cardiorespiratory fitness (CRF) is associated with cardiovascular disease (CVD) independent of obesity. Extracellular vesicles (EVs) are a novel target CVD, however, it remains unknown if obese individuals very poor (VPF) have elevated EVs versus people (PF). Thus, we tested whether VPF was greater EV subtypes in adults. Subjects (n = 13, VO2peak: 15.4 ± 0.6 mL/kg/min, BMI: 34.1 1.7 kg/m2) and PF 25.9 3.0 32.1 1.2 were compared this cross-sectional study. After an overnight fast,...
Examine if adding aerobic exercise to standard medical care (EX+SC) prior bariatric surgery improves metabolic health in relation surgical outcomes.Fourteen patients (age: 42.3±2.5y, BMI: 45.1±2.5 kg/m2) met inclusion criteria and were match-paired pre-operative SC (n = 7) or EX+SC 7; walking 30min/d, 5d/wk, 65-85% HRpeak) for 30d. A 120min mixed meal tolerance test was performed pre- post-intervention (~2d surgery) assess insulin sensitivity (Matsuda Index) flexibility (indirect...
Introduction . The impact of interval (INT) vs. continuous (CONT) exercise training on endothelial function in relation to glucose metabolism prior clinically meaningful weight loss is unknown adults with prediabetes. Methods Twenty-six subjects prediabetes (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>60</mml:mn><mml:mo>±</mml:mo><mml:mn>1</mml:mn></mml:math> y; <mml:math id="M2"><mml:mn>33</mml:mn><mml:mo>±</mml:mo><mml:mn>1</mml:mn></mml:math> kg/m 2 ; 2-hr-PG...
Arterial stiffness is considered a predictor of cardiovascular disease. Females have higher values arterial than males, suggesting greater risk heart-related complications. Although low-calorie diet (LCD) reduces fasting stiffness, in part through weight loss, it unknown if interval exercise (INT) adds to the benefit LCD on and postprandial females with obesity.
Objective. Examine the effect of aerobic exercise (EX) combined with standard medical care (SC) (EX+SC) compared to SC alone on cardiometabolic health and quality life in relation surgical outcomes. Methods. Patients receiving bariatric surgery were match-paired 30 d pre-operative (n=7, 1 male, 39.05.3 y, body mass index 46.4±3.0 kg/m2; low calorie diet) or EX+SC (n = 7, 0 males, 45.64.8 43.9±4.2 walking 30min/d, 5d/wk, 65-85% HRpeak). Body mass, waist circumference, cardiorespiratory...
ABSTRACT Background Extracellular vesicles (EV) are purported to mediate type 2 diabetes and CVD risk development. Physical activity a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would EV compared with continuous (CONT) exercise in adults prediabetes. Methods Eighteen obese (age, 63.8 ± 1.5 yr; body mass index, 31.0 1.3 kg·m −2 ) were screened for prediabetes using American Diabetes Association criteria (75 g oral glucose...
Although extracellular vesicles (EVs) are a novel biomediator of type 2 diabetes (T2D) and cardiovascular disease (CVD), the effects hyperglycemia on EVs in humans is unknown. We tested hypothesis that 75-g oral glucose tolerance test (OGTT) would promote changes relation to CVD risk. Twenty-five obese adults (Age: 52.4 ± 3.2 year, BMI: 32.5 1.2 kg/m²) were screened for normal (NGT, n = 8) prediabetes (PD, 17) using American Diabetes Association criteria (75 g OGTT and/or HbA1c). Body...
We determined if interval exercise plus a low-calorie diet (LCD + INT) increases endothelial function more than an energy-matched LCD. Obese women (47.2 ± 2.6y, 37.5 1.3kg/m2) were randomized to 13 days of LCD (n = 12; mixed meals ~ 1200kcal/d) or INT 13; 12 supervised 60-min bouts 3 min at 90% and 50% HRpeak). subjects received 350kcal postexercise equate energy availability with Fitness (VO2peak) body composition (BodPod) 120 min, 75 g oral glucose tolerance test was performed examine...
Stine, KA, Moxey, JR, Gilbertson, NM, Malin, SK, and Weltman, AL. Effects of feedback type personality on 2,000-m ergometer performance in female varsity collegiate rowers. J Strength Cond Res 33(8): 2170-2176, 2019-Rowing is routinely tested ergometers, involving visual cues verbal encouragement, whereas on-water rowing lacks the cues. Personality also hypothesized to influence performance. The purpose was examine effects determine impact Thirty-eight rowers (body mass 75.0 ± 5.7 kg height...
Substance use disorders are a highly prevalent group of chronic diseases with devastating individual and public health consequences. Current treatment strategies suffer from high rates relapse, or return to drug use, novel solutions desperately needed. Realize Analyze Engage (RAE) is digital, mHealth intervention that focusses on real time, objective detection high-risk events (stress craving) deploy just-in-time supportive interventions. The present study aims (1) evaluate the accuracy...