A5042724623- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Breastfeeding Practices and Influences
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- School Health and Nursing Education
- Birth, Development, and Health
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Infant Development and Preterm Care
- Obesity, Physical Activity, Diet
- Travel-related health issues
- Pediatric health and respiratory diseases
- Child Nutrition and Feeding Issues
- Child and Adolescent Psychosocial and Emotional Development
- Respiratory Support and Mechanisms
- Vitamin D Research Studies
- Restraint-Related Deaths
- Preterm Birth and Chorioamnionitis
- Immunodeficiency and Autoimmune Disorders
Bristol Royal Hospital for Children
2020-2025
University of Bristol
2013-2025
Institute of Child Health
2015-2024
University College London
2009-2020
University of Southampton
2009-2020
Great Ormond Street Hospital
2009-2019
Great Ormond Street Hospital for Children NHS Foundation Trust
2019
Meyer Children's Hospital
2017
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2015
Southampton Children's Hospital
2015
<h3>Background</h3> The long-term prognosis of Henoch-Schönlein Purpura (HSP) is predominantly determined by the extent renal involvement. There no consensus as to whether treatment with prednisolone at presentation can prevent or ameliorate progression nephropathy in HSP. <h3>Methods</h3> Children under 18 years age new-onset HSP were randomly assigned receive placebo for 14 days. primary outcomes (a) presence proteinuria 12 months (defined urine protein : creatinine ratio (UP UC) >20...
The Statement addresses adults and children with the following conditions or undergoing procedures: ► Airflow obstruction including asthma COPD.► Bronchopulmonary dysplasia.► Cystic fibrosis (CF).► Non-CF bronchiectasis.► Restrictive respiratory disease interstitial lung (ILD), muscle chest wall disorders.► Thoracic surgery other interventional procedures.► Pleural pneumothorax pleural effusion.► Respiratory infections.► Obstructive sleep apnoea syndrome (OSAS) obesity hypoventilation...
<h3>Background</h3> Little is known about whether patterns of early growth are associated with altered respiratory and immune development. This study relates prenatal infant to wheeze atopy at age 3 years. <h3>Methods</h3> Birth weight length were measured in 1548 children born term. Conditional fetal head abdominal circumference velocities calculated from antenatal ultrasound measurements. postnatal weight, adiposity data. Measures size conditional related parentally-reported childhood...
<h3>Background</h3> Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher intake during pregnancy has been shown to lower risk of wheeze, yet a study maternal late-pregnancy serum 25-hydroxyvitamin suggested higher concentrations may be associated with increased asthma. <h3>Objective</h3> To assess mothers9 status wheeze phenotypes in their children at age 6 years. Also explore objective measures atopy lung...
Background: Evidence on the effect of maternal complications in pregnancy wheezing offspring is still insufficient. Methods: A pooled analysis was performed individual participant data from fourteen European birth cohorts to assess relationship between several and symptoms offspring. Exposures interest included hypertension preeclampsia, diabetes, as well pre-pregnancy overweight (body mass index 25 29.9) obesity ≥30) compared with normal weight 18.5 24.9). Outcomes both ever recurrent up...
Abstract Background In 1995 the Tucson Children's Respiratory Study (TCRS) identified clinically distinct phenotypes amongst early wheezers; Avon Longitudinal of Parents And Children (ALSPAC) has recently re‐examined these. Objectives To validate statistically derived ALSPAC in Southampton Women's Survey (SWS) using infant and 6‐year lung function, allergic sensitization at 1, 3, 6 years, comparing these with TCRS phenotypes. Methods Complete follow‐up data were available for 926 children,...
Inappropriate prescribing in primary care was implicated nearly half of asthma deaths reviewed the UK's recent National Review Asthma Deaths. Using anonymised EMIS-Web data for 139 ethnically diverse general practices (total population 942,511) extracted from North and East London Commissioning Support Unit, which holds hospital Secondary Uses Services (SUS)-linked data, we examined prevalence over-prescribing short-acting β2-agonist inhalers (SABA), under-prescribing inhaled corticosteroid...
Evidence on the association between mode of delivery and asthma at school age is inconclusive. We assessed associations specific modes in children from 9 European birth cohorts that enrolled participants 1996 2006. Cohort-specific crude adjusted risk ratios for ages 5-9 years were calculated using Poisson regression models pooled. A sensitivity analysis was carried out born term to reduce confounding due perinatal factors. The study included 67,613 participants. rates cesarean varied 9.4%...
<h3>Background</h3> Obesity and asthma have increased in westernised countries. Maternal obesity may increase childhood risk. If this relation is causal, it be mediated through factors associated with maternal adiposity, such as fetal development, pregnancy complications or infant adiposity. We investigated the relationships of body mass index (BMI) fat wheeze, examined influences weight gain obesity. <h3>Methods</h3> prepregnancy BMI estimated (from skinfold thicknesses) were related to...
The objective of this systematic review was to (1) identify existing digital interventions for adolescent depression and anxiety, (2) assess the promise those interventions, (3) characteristics promising interventions. Six databases (PubMed, PsycINFO, Web Science, EMBASE, MEDLINE, Google Scholar) were used conduct searches between September October 2023. rerun in June 2024. Twenty studies met criteria inclusion, leading identification 17 distinct analysis. assessed through their...
Asthma is the most common chronic disease of childhood. Acute asthma attacks are a frequent reason for emergency presentation in children and young people (CYP), fatal can occur even those thought to have mild disease. treatment UK has until recently relied heavily on strategy regular ‘maintenance’ inhaled corticosteroid (ICS) separate ‘reliever’ inhalers containing short-acting beta-agonist (SABA) taken as needed relieve symptoms (most commonly relievers contain salbutamol). This vulnerable...
Βackground After the COVID-19 pandemic, children and young people (CYP) with long covid were managed in specialist clinics. However, there is limited research on how CYP who accessed clinics experienced them. Methods We aimed to evaluate acceptable paediatric services patients. Semi-structured qualitative interviews 13 patients used understand experiences of covid. Recruited participants aged 11–17 years old, had a diagnosis, service Southwest England from June 2022 September 2023....
Background Guidelines recommend Emergency Department (ED) healthcare professionals (HCPs) ensure patients have a supply of inhaled corticosteroid on discharge after an acute asthma presentation. By optimising medication, presentations to EDs are potentially reachable moment improve long-term management as well treating the exacerbation. Optimising medication for requires behavioural changes from HCPs, which may be considered unacceptable or unfeasible. Understanding health beliefs and...
Purpose: For individuals with mild cognitive impairment (MCI), memory loss may prevent successful engagement in exercise, a key factor preventing additional disability. The Resources and Activities for Life Long Independence (RALLI) program uses behavioral principles to make exercise more accessible these individuals. Exercises are broken into small steps, sequenced, linked cues help participants remember them. Memory aids, easy-to-follow instructions, tracking forms facilitate adherence...
Abstract Background Maternal obesity is increasingly prevalent in many westernized countries. Many studies report associations between maternal and childhood wheeze or asthma but few have considered relation to respiratory infections symptoms other than during infancy. This study assesses the relationship BMI reported wheeze, cough first year of life. Methods In 2799 mother‐child pairs, we examined relations pre‐pregnancy pregnancy weight gain offspring prolonged cough, lower tract...